α-Klotho对人类健康和长寿至关重要。然而,微量元素与α-Klotho水平的关系有待进一步研究。我们旨在探讨血清硒(Se)水平,铜(Cu),和锌(Zn),和血清α-Klotho水平。我们分析了2011-2016年全国健康和营养调查的2138个样本,和加权线性回归,WQS,和qgcomp模型用于评估这些元素对血清α-Klotho水平的影响,单独和组合。血清铜浓度与血清α-Klotho水平呈负相关(β=-0.128,95%CI-0.196,-0.059),随着Cu浓度等级的增加,血清α-Klotho水平逐渐降低(Ptrend=0.002)。WQS模型表现出硒的综合效应之间的负相关,Cu,锌和血清α-Klotho水平(β=-0.035,95CI-0.060,-0.010),在男性(β=-0.038(-0.059,-0.017))和40-49岁年龄组(β=-0.059,95%CI-0.119,-0.012)中一致。qgcomp模型反映了这些发现,硒的综合效应指数呈负相关,Cu,和锌与血清α-Klotho水平(β=-0.027,95%CI-0.047,-0.006),在女性(β=-0.032,95%CI-0.061,-0.004)和BMI≥25的个体(β=-0.030,95%CI-0.054,-0.006)中一致,和40-49岁年龄组(β=-0.047,95%CI-0.088,-0.006)。升高的血清Cu水平可能与较低的血清α-Klotho水平有关。血清硒的联合作用,Cu,锌与血清α-Klotho水平呈负相关,铜的贡献最大。我们的发现为评估微量营养素在维持人类健康中的作用提供了重要见解。
The α-Klotho is crucial for human health and longevity. However, the relationship between trace elements and α-Klotho levels needs further investigation. We aimed to explore the relationship between serum levels of selenium (Se), copper (
Cu), and zinc (Zn), and serum α-Klotho levels. We analyzed 2138 samples from the 2011-2016 National Health and Nutrition Examination Survey, and the weighted linear regression, WQS, and qgcomp models were utilized to evaluate the effects of these elements on serum α-Klotho levels, individually and combined. A negative correlation was observed between serum
Cu concentration and serum α-Klotho levels (β = - 0.128, 95% CI - 0.196, - 0.059), with each increase in Cu concentration grade showing a gradual decrease in serum α-Klotho levels (Ptrend = 0.002). The WQS model exhibited a negative correlation between the combined effect of Se,
Cu, and Zn and serum α-Klotho levels (β = - 0.035, 95%CI - 0.060, - 0.010), consistently in males (β = - 0.038 (- 0.059, - 0.017)) and in the 40-49 age group (β = - 0.059, 95% CI - 0.119, - 0.012). The qgcomp model mirrored these findings, showing a negative correlation in the combined effect index of Se, Cu, and Zn with serum α-Klotho levels (β = - 0.027, 95% CI - 0.047, - 0.006), consistent in females (β = - 0.032, 95% CI - 0.061, - 0.004) and in individuals with BMI ≥ 25 (β = - 0.030, 95% CI - 0.054, - 0.006), and in the 40-49 age group (β = - 0.047, 95% CI - 0.088, - 0.006). Elevated serum
Cu levels may be associated with lower serum α-Klotho levels. The combined effect of serum Se, Cu, and Zn shows a negative correlation with serum α-Klotho levels, with
Cu contributing the most. Our findings provide significant insights into assessing the role of trace nutrients in maintaining human health.