背景:克里米亚-刚果出血热病毒(CCHFV)在伊拉克流行,在过去的五年中,不断观察到反复流行的流行病。本研究旨在确定2022年DhiQar省与克里米亚-刚果出血热(CCHF)病例相关的因素。
方法:采用检测阴性病例对照设计分析621例CCHF患者,其中162例确诊,459例为疑似病例。为了识别确诊和疑似病例,使用逆转录聚合酶链反应(RT-PCR)。选取PCR检测结果阴性的可疑患者作为对照组。收集了有关CCHF潜在风险因素的数据,作为DhiQar省相同地理位置的前几年的现有数据。Logistic回归分析用于确定可能的危险因素与确诊的CCHF病例之间的相关性。
结果:CCHF的发生率为每100,000人中6.8%。病死率为7.7%的患者死亡总数为48例。患者年龄从1岁到65岁不等,总体平均值±SD为36.08±18.29年。98.2%的患者年龄在15至65岁之间;58%的报告患者为男性,男女比例为1.4:1。此外,与生肉接触,动物接触,在CCHF阳性病例中,蜱咬伤的百分比最高。
结论:男性,像家庭主妇这样的高风险工作,卫生工作人员,牧羊人,屠夫,动物贩子,屠宰场工人,兽医人员,和农民,蜱叮咬,与生肉的接触是2022年DhiQar省CCHF发病率增加的有统计学意义的预测因素。
BACKGROUND: Crimean-Congo hemorrhagic fever virus (CCHFV) is endemic in Iraq, where recurrent epidemics have been constantly observed during the last five years. The present study aimed to determine the factors associated with Crimean-Congo hemorrhagic fever (CCHF) cases in Dhi Qar province during the year 2022.
METHODS: A test-negative case-control design was used to analyze 621 CCHF patients, of which 162 were confirmed and 459 were suspected cases. To identify the confirmed and suspected cases, reverse transcriptase polymerase chain reaction (RT-PCR) was used. Suspected patients whose PCR test results were negative were selected as the control group. Data on potential risk factors for CCHF were collected as existing data for previous years for the same geographical locations in Dhi Qar province. Logistic regression analyses were used to determine the correlation between probable risk factors and confirmed CCHF cases.
RESULTS: The incidence rate of CCHF was 6.8% per 100,000 people. The total number of deaths was 48 for patients with a case fatality rate of 7.7%. The patients\' ages ranged from one year to 65 years, with an overall mean ± SD of 36.08 ± 18.29 years. A total of 98.2% of the patients were between 15 and 65 years of age; 58% of the reported patients were male, and the male-to-female ratio was 1.4:1. Additionally, contact with raw meat, animal contact, and tick bite had the highest percentages for CCHF positivity cases.
CONCLUSIONS: Male gender, high-risk jobs like housewives, health staff, shepherds, butchers, animal dealers, slaughterhouse workers, veterinary staff, and farmers, tick bites, and contact with raw meat were statistically significant predictors for increasing CCHF incidence in Dhi Qar province during the year 2022.