■梅毒,一种普遍的性传播感染,构成严重风险,尤其是在怀孕期间。本研究旨在阐明广西梅毒流行趋势和影响,中国,专注于患病率,临床表现,以及孕妇和新生儿的治疗结果。目标包括了解受影响孕妇的人口特征,分析新生儿的临床表现,并评估治疗方案的有效性。
■遵守道德准则,2013年1月至2023年12月的一项回顾性队列研究纳入了54,048名接受梅毒螺旋体检测的孕妇.诊断涉及全面的方法,利用测试如甲苯胺红不加热血清测试(TRUST)和梅毒螺旋体颗粒凝集(TPPA)测定。通过长达十年的随访评估了婴儿的诊断和临床表现。治疗方案,包括苄星青霉素,已实施。使用SAS版本9.4进行统计分析。
■在54,048名孕妇中,0.10%为梅毒阳性,与住院率上升有关。新生儿表现出不同的临床表现,新生儿肺炎和黄疸很普遍。治疗方案,尤其是苄星青霉素,取得了显著的100%治愈成功率。该研究指出,母婴传播显着减少。母亲和婴儿的梅毒在不同的临床阶段被诊断出来,包括主要的,次要,潜在的,和第三。
■这项研究强调了梅毒对广西孕妇和新生儿的影响,中国。调查结果强调了采取强有力的预防措施的必要性,早期诊断,和有效的治疗策略。观察到的100%使用苄星青霉素的治愈成功率强调了严格治疗方案在减轻先天性梅毒的不良反应和减少其传播方面的重要性。
UNASSIGNED: Syphilis, a prevalent sexually transmitted infection, poses severe risks, especially during pregnancy. This study aimed to elucidate the trends and impacts of syphilis in Guangxi, China, focusing on prevalence, clinical manifestations, and treatment outcomes in pregnant women and newborns. The objectives included understanding the demographic characteristics of affected pregnant women, analysing the clinical manifestations in newborns, and assessing the effectiveness of the treatment protocol.
UNASSIGNED: Conducted in adherence to ethical guidelines, a retrospective cohort study from January 2013 to December 2023 included 54,048 pregnant women tested for T. pallidum. Diagnosis involved a comprehensive approach, utilizing tests like the Toluidine Red Unheated Serum Test (TRUST) and the Treponema pallidum Particle Agglutination (TPPA) assay. Infant diagnosis and clinical manifestations were evaluated through a decade-long follow-up. Treatment protocols, including Benzathine penicillin, were implemented. Statistical analyses were conducted using SAS version 9.4.
UNASSIGNED: Among 54,048 pregnant women, 0.10% were syphilis positive, correlating with a rise in hospitalizations. Newborns exhibited varied clinical manifestations, with neonatal pneumonia and jaundice being prevalent. The treatment protocol, especially with Benzathine penicillin, achieved a remarkable 100% cure success rate. The study noted a significant reduction in mother-to-child transmission. Syphilis in mothers and babies was diagnosed at different clinical stages, including primary, secondary, latent, and tertiary.
UNASSIGNED: This study underscores the escalating impact of syphilis on pregnant women and newborns in Guangxi, China. The findings highlight the necessity for robust preventive measures, early diagnosis, and effective treatment strategies. The observed 100% cure success rate with Benzathine penicillin emphasizes the importance of strict treatment protocols in mitigating the adverse effects of congenital syphilis and reducing its transmission.