目的:不合理的配药做法是抗生素滥用和抗生素耐药性传播的原因。因此,本研究旨在评估知识,态度,以及社区药剂师(CPs)关于无处方分配抗生素(DAwP)的做法。
方法:描述性,横断面研究于2023年3月1日至2023年3月31日在拉合尔社区药房进行,巴基斯坦。数据收集使用自我管理和预先测试的问卷。采用Logistic回归分析确定与社区药师实践相关的因素。使用SPSS(版本26)和MSOffice(2016)分析数据。
结果:在359名受访者中,许多人强烈同意/同意“DAwP正在促进抗菌素耐药性的发展”(83%,n=298)和“抗生素耐药性已成为公共卫生问题”(81.9%,n=249)。总的来说,大多数社区药剂师声称,患者不愿意因非严重感染去看医生(75.2%,n=270)和药剂师对抗生素使用的良好知识(51%,n=183)是最常见的原因,可归因于无处方分配抗生素。头孢菌素(n=260,72.4%),青霉素(n=254,70.8%),和四环素(n=170,47.4%)是最常分配的抗生素类,没有处方由于感冒,流感和腹泻。大多数社区药剂师从不/有时会警告患者药物的潜在副作用(79.1%,n=284)。Logistic回归分析显示,31-40岁的社区药剂师(OR=0.568,95CI=0.348-0.927,p值=0.024)与不按处方分配抗生素(DAwP)的不良做法明显较少相关,而那些是“管理者”(OR=4.222,95CI=2.542-7.011,p值=<0.001),有3-5年的经验(OR=2.241,95CI=1.183-4.243,p值=0.013),每天分配≤25种抗生素(OR=12.375,95CI=5.177-29.583,p值=<0.001),更可能与在没有处方的情况下分配抗生素的不良做法有关。
结论:社区药师有足够的知识,积极的态度,以及对DAwP的不良做法。人口因素,如年龄,工作状态,和工作经验是社区药剂师不处方分配抗生素(DAwP)的决定因素。因此,多方面的方法,包括教育干预,需要减少无处方抗生素(DAwP)的分配。
OBJECTIVE: The irrational dispensing practices are responsible for antibiotic abuse and the spread of antibiotic resistance. Thus, the present study aims to evaluate the knowledge, attitudes, and practices of community pharmacists (CPs) regarding dispensing antibiotics without prescription (DAwP).
METHODS: A descriptive, cross-sectional study was conducted between March 1, 2023, and March 31, 2023, in community pharmacy settings of Lahore, Pakistan. A self-administered and pretested questionnaire was used for the data collection. Logistic regression analysis was used to determine the factors associated with the practices of community pharmacists. Data were analyzed using SPSS (version 26) and MS Office (2016).
RESULTS: Among 359 respondents, many strongly agreed/agreed with the statements \"DAwP is contributing to the development of antimicrobial resistance\" (83%, n = 298) and \"Antibiotic resistance has become a public health issue\" (81.9%, n = 249). Overall, most of the community pharmacists claimed that the unwillingness of patients to visit physicians for non-serious infections (75.2%, n = 270) and good knowledge of pharmacists about the use of antibiotics (51%, n = 183) were the most common reasons attributable to dispensing of antibiotics without prescription. Cephalosporin (n = 260, 72.4%), penicillin (n = 254, 70.8%), and tetracyclines (n = 170, 47.4%) were the most commonly dispensed classes of antibiotics without prescription due to cold, flu and diarrhea. Most community pharmacists never/sometimes warn patients about the potential side effects of medicines (79.1%, n = 284). Logistic regression analysis revealed that community pharmacists 31-40 years of age (OR = 0.568, 95%CI = 0.348-0.927, p-value = 0.024) were significantly less associated with poor practices of dispensing antibiotics without prescription (DAwP) while those who were \'Managers\' (OR = 4.222, 95%CI = 2.542-7.011, p-value = <0.001), had 3-5 years of experience (OR = 2.241, 95%CI = 1.183-4.243, p-value = 0.013), dispensed ≤25 antibiotics per day (OR = 12.375, 95%CI = 5.177-29.583, p-value = <0.001), were more likely to be associated with poor practices of dispensing of antibiotics without prescription.
CONCLUSIONS: The community pharmacists had adequate knowledge, positive attitudes, and poor practices towards DAwP. Demographical factors such as age, job status, and work experience were the determinants of community pharmacists\' practices towards dispensing antibiotics without prescription (DAwP). Hence, a multifaceted approach, including educational interventions, is needed to reduce the dispensing of antibiotics without prescription (DAwP).