卒中后抑郁(PSD)是一种普遍的精神疾病,影响约三分之一的卒中幸存者,显着阻碍恢复和生活质量。PSD还给护理人员和医疗保健系统带来了沉重负担。芳香疗法在缓解抑郁症方面显示出了希望,焦虑,和睡眠障碍。这项初步的随机对照试验旨在评估混合草药芳香疗法治疗PSD的可行性和初步疗效。可行性结果包括招聘,干预依从性,评估完成和安全评估。次要结果包括对抑郁症的评估,焦虑,认知功能,睡眠质量,生活质量,使用EEG和fNIRS的脑功能。
■这项单盲先导随机对照试验将在上海市第二康复医院进行,纳入99名卒中后PSD患者。参与者将被随机分为三组:接受标准化康复治疗的非主动对照组,CBT小组接受常规康复,每两周一次的CBT会议,和一个芳香疗法组接受常规康复和每日芳香吸入疗程。干预将持续四周,在基线时评估疗效,干预后,干预后一个月。评分量表将用于测量抑郁症的变化,睡眠质量,认知功能,和生活质量。EEG和fNIRS将专门用于测量大脑皮层活动的变化及其与抑郁症的相关性。可行性将通过招聘进行评估,干预依从性,评估完成和安全评估。
■这项初步研究强调了混合草药芳香疗法吸入治疗PSD的潜力,通过促进自我管理来解决CBT的局限性。在通过招聘证明可行性的同时,坚持,评估完成和安全评估,该研究还承认限制,如不平等的干预时间,缺乏身体功能数据。而且,使用与文化相关的植物粉末可能会增强依从性,但会限制通用性。尽管有这些限制,这项研究为芳香疗法的机制提供了有价值的初步数据和见解,鼓励进一步研究和开发有效的PSD治疗方法。
UNASSIGNED: Post-stroke depression (PSD) is a prevalent psychiatric disorder affecting about one-third of stroke survivors, significantly hindering recovery and quality of life. PSD also imposes a substantial burden on caregivers and healthcare systems. Aromatherapy has shown promise in alleviating depression, anxiety, and sleep disorders. This pilot randomized controlled trial aims to assess the feasibility and preliminary efficacy of mixed herb aromatherapy in treating PSD. Feasibility outcomes encompass recruitment, intervention adherence, assessment completion and safety assessment. Secondary outcomes include evaluations of depression, anxiety, cognitive function, sleep quality, quality of life, and brain function using EEG and fNIRS.
UNASSIGNED: This single-blind pilot randomized controlled trial will be conducted at the Second Rehabilitation Hospital of Shanghai, enrolling ninety-nine post-stroke patients with PSD. Participants will be randomized into three groups: a Non-Active Control Group receiving standardized rehabilitation therapy, a CBT Group receiving conventional rehabilitation with bi-weekly CBT sessions, and an Aromatherapy Group receiving conventional rehabilitation with daily aromatic inhalation sessions. Interventions will last for four weeks, with efficacy assessed at baseline, post-intervention, and one month post-intervention. Rating scales will be used to measure changes in depression, sleep quality, cognitive function, and quality of life. EEG and fNIRS will specifically be used to measure changes in cerebral cortex activity and their correlations with depression. Feasibility will be evaluated through recruitment, intervention adherence, assessment completion and safety assessment.
UNASSIGNED: This pilot study highlights the potential of mixed herb aromatherapy inhalation for treating PSD, addressing limitations of CBT by promoting self-management. While demonstrating feasibility through recruitment, adherence, assessment completion and safety assessment, the study also acknowledges limitations such as unequal intervention times, the lack of physical function data. And the use of culturally relevant plant powders may enhance compliance but limits generalizability. Despite these constraints, the study provides valuable preliminary data and insights into the mechanisms of aromatherapy, encouraging further research and development of effective PSD treatments.