■本研究旨在评估组合水解2型胶原蛋白的效果,甲磺酰基甲烷(MSM),硫酸葡糖胺(GS),并补充硫酸软骨素(CS)对膝骨关节炎(OA)患者膝关节疼痛强度的影响。
■这个多中心,观察,非干预性研究包括98例患者(78例女性,20名男性;平均年龄:52.8±6.5岁;范围,40至64岁),在2022年5月至2022年11月期间患有1-3级膝关节OA。患者被处方为水解2型胶原蛋白的组合,MSM,GS,和CS作为膝关节OA的补充。包含1250毫克水解2型胶原蛋白的组合补充剂的小袋形式,750毫克MSM,750毫克GS,并连续两个月每天一次使用400mgCS。根据西安大略省和麦克马斯特大学骨关节炎指数(WOMAC)对患者进行评估,视觉模拟量表(VAS)-疼痛,健康评估问卷(HAQ)。在第1次访视(基线;研究的第0天)后,安排患者进行4周(访视2)和8周(访视3)的随访。
■对于VAS疼痛,WOMAC,WOMAC-分量表,和HAQ分数,3次访视之间的改善差异显著(均p<0.001).患者对补充剂的依从性中位数为96.77%,访问2和访问3。
■水解2型胶原蛋白的组合,MSM,GS,和CS在膝OA治疗八周被认为是一种有效和安全的营养补充剂。
UNASSIGNED: This study aimed to evaluate the effects of the combined hydrolyzed type 2 collagen, methylsulfonylmethane (MSM), glucosamine sulfate (GS), and chondroitin sulfate (CS) supplement on knee pain intensity in patients with knee osteoarthritis (OA).
UNASSIGNED: This multicenter, observational, noninterventional study included 98 patients (78 females, 20 males; mean age: 52.8±6.5 years; range, 40 to 64 years) who had Grade 1-3 knee OA between May 2022 and November 2022. The patients were prescribed the combination of hydrolyzed type 2 collagen, MSM, GS, and CS as a supplement for knee OA. The sachet form of the combined supplement containing 1250 mg hydrolyzed type 2 collagen, 750 mg MSM, 750 mg GS, and 400 mg CS was used once daily for two consecutive months. Patients were evaluated according to the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Visual Analog Scale (VAS)-pain, and Health Assessment Questionnaire (HAQ). Patients were scheduled to visit for follow-up four weeks (Visit 2) and eight weeks (Visit 3) after Visit 1 (baseline; day 0 of the study).
UNASSIGNED: For the VAS-pain, WOMAC, WOMAC-subscale, and HAQ scores, the differences in improvement between the three visits were significant (p<0.001 for all). The patient compliance with the supplement was a median of 96.77%, both for Visit 2 and Visit 3.
UNASSIGNED: The combination of hydrolyzed type 2 collagen, MSM, GS, and CS for eight weeks in knee OA was considered an effective and safe nutritional supplement.