■检查了父母的六种精神病诊断与后代的广泛精神病和非精神病结局之间的关联。
■1970年至2000年在瑞典出生的所有个人都通过瑞典国民登记册与他们的亲生父母(N=3,286,293)联系在一起。匹配的队列设计,采用分层Cox回归和条件逻辑回归分析,用于检查父母的6项精神病诊断与后代的32项结局之间的关联。所有的孩子,包括那些暴露和没有暴露于患有精神病的父母的人,从他们的出生日期到从瑞典移民的日期,死亡,或2013年12月31日,当时后代为14-44岁。
■就绝对风险而言,大多数父母有精神病诊断的儿童没有在专科护理中被诊断出来,在随访结束时,患有16种精神疾病的后代比例从22.17%(暴露于父母抑郁症的后代)到25.05%(暴露于父母药物相关疾病的后代)不等。然而,就相对风险而言,暴露于六个父母精神病诊断中的任何一个增加了后代中32个结局的概率,事件发生时间结局的风险比为1.03~8.46,二元结局的比值比为1.29~3.36.观察到父母诊断精神病和物质相关疾病的一些特异性,更强烈地预测了精神病样和外部化相关的结果,分别,在后代中。
■父母精神病的代际传播在很大程度上表现为转诊,并扩展到后代的非精神病结局。鉴于与结果的广泛关联,服务提供商(例如,精神病医生,教师,和社会工作者)在预测预后和计划干预措施或治疗时,应考虑客户的更广泛的精神病家族史。
UNASSIGNED: Associations were examined between six psychiatric diagnoses in parents and a broad range of psychiatric and nonpsychiatric outcomes in their offspring.
UNASSIGNED: All individuals born in Sweden between 1970 and 2000 were linked to their biological parents (N=3,286,293) through Swedish national registers. A matched cohort design, with stratified Cox regression and conditional logistic regression analyses, was used examine associations between six psychiatric diagnoses in the parents and 32 outcomes in their offspring. All children, including those exposed and those not exposed to parents with psychiatric diagnoses, were followed from their date of birth to the date of emigration from Sweden, death, or December 31, 2013, when the offspring were 14-44 years old.
UNASSIGNED: In terms of absolute risk, most children who had parents with psychiatric diagnoses were not diagnosed in specialist care themselves, and the proportion of offspring having any of the 16 types of psychiatric conditions ranged from 22.17% (of offspring exposed to parental depression) to 25.05% (of offspring exposed to parental drug-related disorder) at the end of follow-up. Nevertheless, in terms of relative risk, exposure to any of the six parental psychiatric diagnoses increased probabilities of the 32 outcomes among the offspring, with hazard ratios that ranged from 1.03 to 8.46 for time-to-event outcomes and odds ratios that ranged from 1.29 to 3.36 for binary outcomes. Some specificities were observed for parental diagnoses of psychosis and substance-related disorders, which more strongly predicted psychotic-like and externalizing-related outcomes, respectively, in the offspring.
UNASSIGNED: The intergenerational transmission of parental psychiatric conditions appeared largely transdiagnostic and extended to nonpsychiatric outcomes in offspring. Given the broad spectrum of associations with the outcomes, service providers (e.g., psychiatrists, teachers, and social workers) should consider clients\' broader psychiatric family history when predicting prognosis and planning interventions or treatment.