目的:探讨妊娠早期交通相关空气污染暴露与分娩结局和婴儿神经认知发育的关系。
方法:队列研究。
方法:符合条件的妇女在两个中心的产科诊所参加了六次就诊,重庆医科大学附属第一医院和重庆市妇女儿童保健中心。
方法:年龄在20至40岁之间,妊娠11-14周且单胎妊娠的妇女有资格参加。如果妇女在妊娠32周前有早产史,则将其排除在外,母乳过敏或厌恶或严重的乳糖不耐受。该分析包括2015-2016年的1273名孕妇和1174名活产婴儿。
方法:他们家庭住址的空气污染浓度,包括直径≤2.5µm的颗粒物(PM2.5)和二氧化氮(NO2),使用土地利用回归模型估计孕前和每三个月期间。
方法:出生结果(即,出生体重,出生长度,早产,低出生体重,胎龄大,胎龄小(SGA)状态)和通过中文版Bayley婴儿发育量表测量的神经发育结局。
结果:在妊娠早期(OR:1.57,95%CI:1.06至2.32)和整个妊娠期间(OR:1.33,99%CI:1.01至1.75)发现SGA和NO2的每IQR增加之间存在关联。受孕前90天的PM2.5和NO2暴露均与较低的精神运动发育指数评分相关(β:-6.15,95%CI:-8.84至-3.46;β:-2.83,95%CI:-4.27至-1.39,分别)。在怀孕的不同时期,NO2暴露的增加与精神运动发育延迟的风险增加有关。
结论:怀孕期间NO2暴露量增加与SGA和精神运动发育延迟的风险增加相关,而受孕前PM2.5和NO2暴露量增加与12月龄时不良精神运动发育结局相关.
背景:ChiCTR-IOR-16007700。
OBJECTIVE: To investigate the associations of traffic-related air pollution exposures in early pregnancy with birth outcomes and infant neurocognitive development.
METHODS: Cohort study.
METHODS: Eligible women attended six visits in the maternity clinics of two centres, the First Affiliated Hospital of Chongqing Medical University and Chongqing Health Centre for Women and Children.
METHODS: Women who were between 20 and 40 years of age and were at 11-14 weeks gestation with a singleton pregnancy were eligible for participation. Women were excluded if they had a history of premature delivery before 32 weeks of gestation, maternal milk allergy or aversion or severe lactose intolerance. 1273 pregnant women enrolled in 2015-2016 and 1174 live births were included in this analysis.
METHODS: Air pollution concentrations at their home addresses, including particulate matter with diameter ≤2.5 µm (PM2.5) and nitrogen dioxide (NO2), during pre-conception and each trimester period were estimated using land-use regression models.
METHODS: Birth outcomes (ie, birth weight, birth length, preterm birth, low birth weight, large for gestational age and small for gestational age (SGA) status) and neurodevelopment outcomes measured by the Chinese version of Bayley Scales of Infant Development.
RESULTS: An association between SGA and per-IQR increases in NO2 was found in the first trimester (OR: 1.57, 95% CI: 1.06 to 2.32) and during the whole pregnancy (OR: 1.33, 99% CI: 1.01 to 1.75). Both PM2.5 and NO2 exposure in the 90 days prior to conception were associated with lower Psychomotor Development Index scores (β: -6.15, 95% CI: -8.84 to -3.46; β: -2.83, 95% CI: -4.27 to -1.39, respectively). Increased NO2 exposure was associated with an increased risk of psychomotor development delay during different trimesters of pregnancy.
CONCLUSIONS: Increased exposures to NO2 during pregnancy were associated with increased risks of SGA and psychomotor development delay, while increased exposures to both PM2.5 and NO2 pre-conception were associated with adverse psychomotor development outcomes at 12 months of age.
BACKGROUND: ChiCTR-IOR-16007700.