背景:特应性皮炎(AD)是一种常见且反复发作的炎症性疾病,具有很强的遗传易感性。趋化因子的异常产生在AD的发生、成长中起主要感化。
方法:在中国国家知识基础设施数据库中进行了全面的在线文献检索,万方,VIP中国科技期刊数据库,中国生物医学文献数据库,PubMed,Embase和Cochrane图书馆检索2000年1月至2022年10月发表的相关文章。使用比值比(OR)及其95%置信区间(CI)来计算这种关系。
结果:最终筛选出7项研究,包括1316名AD患者和1099名对照。有3项关于CC趋化因子配体5(CCL5)多态性的研究,2对于CCL11多态性,CCL17多态性为2,分别。荟萃分析显示,在等位基因模型下,CCL5-403G/A多态性与AD之间存在显着关联(AvsG:OR=1.25,95%CI=1.02-1.52,P=0.03),固定效应模型中的杂合模型(AGvsGG:OR=1.40,95%CI=1.08-1.80,P=0.01)和显性模型(AAAGvsGG:OR=1.38,95%CI=1.08-1.76,P=0.01)。CCL5-28C/G多态性的等位基因模型(GvsC:OR=1.46,95%CI=1.07-1.98,P<0.01)和显性模型(GGGCvsCC:OR=1.74,95%CI=1.23-2.47,P<.001)也与AD风险增加有关。然而,在其他等位基因和基因型中未发现这种显著关联(P>.05)。
结论:我们的结果表明A等位基因,AG和AA+AG基因型的CCL5-403G/A多态性,CCL5-28C/G多态性的G等位基因和GG+GC基因型是AD的危险因素。未来仍需进行大量研究以进一步探索这些相关性。
BACKGROUND: Atopic dermatitis (AD) is a common and recurrent inflammatory disease with strong genetic susceptibility. The abnormal production of chemokines plays an important role in the occurrence and development of AD.
METHODS: A comprehensive online literature search was performed in databases of China National Knowledge Infrastructure, Wanfang, VIP China Science and Technology Journal Database, China Biomedical Literature Database, PubMed, Embase and Cochrane Library to retrieve relevant articles published from January 2000 to October 2022. The odds ratio (OR) with its 95% confidence interval (CI) was employed to calculate this relationship.
RESULTS: A total of 7 studies were finally screened out, including 1316 AD patients and 1099 controls. There were 3 studies for CC chemokine ligand 5 (CCL5) polymorphisms, 2 for CCL11 polymorphisms, and 2 for CCL17 polymorphisms, respectively. The meta-analysis revealed a significant association between the CCL5 - 403G/A polymorphism and AD under the allelic model (A vs G: OR = 1.25, 95% CI = 1.02-1.52, P = .03), heterozygous model (AG vs GG: OR = 1.40, 95% CI = 1.08-1.80, P = .01) and dominant model (AA + AG vs GG: OR = 1.38, 95% CI = 1.08-1.76, P = .01) in a fixed-effect model. The allelic model (G vs C: OR = 1.46, 95% CI = 1.07-1.98, P < .01) and dominant model (GG + GC vs CC: OR = 1.74, 95% CI = 1.23-2.47, P < .001) of the CCL5 - 28C/G polymorphism were also associated with an increased risk of AD. However, this significant association was not found in other alleles and genotypes (P > .05).
CONCLUSIONS: Our results show that the A allele, AG and AA + AG genotypes of the CCL5 - 403G/A polymorphism, the G allele and GG + GC genotype of the CCL5 - 28C/G polymorphism are risk factors for AD. Future studies with large population are still needed to further explore those correlations.