背景:Sileneundulata在历史上用于诱导生动和预言的清醒梦,但是关于其植物化学成分和潜在药理特性的信息有限。
目的:本研究的目的是通过LC-MS/MS分析研究山竹的植物化学成分,探讨其潜在的5-羟色胺能活性,这可以支持和证实S.undulata作为一种诱导梦想的植物的传统用途。
方法:对S.undulata提取物进行LC-MS/MS分析,鉴定出51种植物化学物质,包括Norharman,harmalol,Harmaline,Harmine,和伊博加因生物碱.采用ADMET和分子对接研究来评估这些化合物的血清素能潜能。
结果:分析显示存在β-咔啉生物碱,比如norharman,harmalol,Harmaline,Harmine,还有伊博加因,在S.undulata提取物中。ADMET分析显示这些化合物具有良好的药代动力学性质。此外,分子对接研究表明,harmaline(-8.90Kcal/mol),harmalol(-8.56Kcal/mol),和ibogaine(-8.75Kcal/mol)表现出与对照分子相当的结合亲和力,LSD(-9.14Kcal/mol),表明血清素5-HT2A受体的潜在激动活性。
结论:这些发现提供了对S.undulata的潜在治疗益处的见解,支持其作为精神活性植物的传统用途。本研究首次研究了S.undulata的化学成分和潜在的5-羟色胺能激动剂活性。虽然有希望,进一步的研究是必要的,以发现额外的药用特性相关的植物化学成分。
BACKGROUND: Silene undulata is historically used for inducing vivid and prophetic lucid dreams, but limited information exists on its phytochemical composition and potential pharmacological properties.
OBJECTIVE: This study aimed to investigate the phytochemical composition of S. undulata through LC-MS/MS analysis and explore its potential serotonergic activity, which could support and confirm the traditional use of S. undulata as a dream-inducing plant.
METHODS: LC-MS/MS analysis was conducted on S. undulata extract, identifying 51 phytochemicals, including norharman, harmalol, harmaline, harmine, and ibogaine alkaloids. ADMET and Molecular docking investigations were employed to assess the serotonergic potential of these compounds.
RESULTS: The analysis revealed the presence of β-carboline alkaloids, such as norharman, harmalol, harmaline, harmine, and ibogaine, within S. undulata extract. ADMET analysis showed that these compounds have a favourable pharmacokinetic properties. In addition, molecular docking investigations showed that harmaline (-8.90 Kcal/mol), harmalol (-8.56 Kcal/mol), and ibogaine (-8.75 Kcal/mol) exhibited binding affinities comparable to the control molecule, LSD (-9.14 Kcal/mol), indicating potential agonistic activity at serotonin 5-HT2A receptor.
CONCLUSIONS: These findings provide insights into the potential therapeutic benefits of S. undulata, supporting its traditional use as a psychoactive plant. This study investigated the chemical constituents and potential serotonergic agonist activity of S. undulata for the first time. While promising, further research is necessary to uncover additional medicinal properties associated with the identified phytochemical components.