Abstract：
The illegal drug market is constantly evolving, with new drugs being created and existing ones being modified. Adulterants are often added to the mix, and the primary substance may be secretly replaced by a new one. Once-known tablets can now be vastly different from what they are sold as, all due to the pursuit of profit and evasion of current drug regulations. These alterations in drug composition pose a threat to society, as their effects are still not well understood. Therefore, it is crucial for police intelligence and public health development to obtain the chemical profiles of illicit drugs. This study presents the chemical fingerprinting of ecstasy tablets seized in the state of Rio de Janeiro (Brazil) between 2012 and 2021. The tablet samples were weighed, extracted, diluted with methanol, and acidified before analysis using gas chromatography high-resolution mass spectrometry and attenuated total reflection Fourier transform infrared spectroscopy. The major constituents found were MDMA and clobenzorex, with fewer occurrences of MDA, MDEA, and 2C-B. The results also indicate that the occurrence of mega-events in the study location impacted the chemical fingerprints of ecstasy. A total of 27 combinations of cutting agents, including caffeine, ephedrine, and anesthetics, were identified. Samples composed of clobenzorex were observed throughout the evaluated period in areas near highways, suggesting that this product is mainly used by truck drivers. These findings can help police intelligence units anticipate the behavior of the illicit market during major events, identify traffic routes, and support public health initiatives.
摘要：
非法毒品市场在不断发展,随着新药的产生和现有药物的修改。掺假经常被添加到混合物中，主要物质可能会被新物质秘密取代。曾经已知的平板电脑现在可以与出售的平板电脑大不相同，都是由于追求利润和逃避现行药品法规。这些药物成分的改变对社会构成威胁,因为它们的影响仍然没有得到很好的理解。因此,获取非法药物的化学概况对警察情报和公共卫生发展至关重要。这项研究介绍了2012年至2021年在里约热内卢（巴西）缉获的摇头丸的化学指纹图谱。将片剂样品称重,提取,用甲醇稀释,和酸化前分析使用气相色谱高分辨率质谱和衰减全反射傅里叶变换红外光谱。发现的主要成分是MDMA和clobenzorex，随着MDA的出现减少，MDEA,2C-B结果还表明，研究地点发生的大事件影响了摇头丸的化学指纹。共27种切割剂组合，包括咖啡因,麻黄碱,和麻醉剂，已确定。在整个评估期间，在高速公路附近地区观察到了由氯苯并雷克组成的样品，这表明该产品主要由卡车司机使用。这些发现可以帮助警察情报部门在重大事件中预测非法市场的行为，确定交通路线，并支持公共卫生倡议。
