背景:转移到皮肤的癌症很少见,尤其是宫颈鳞状细胞癌。这里,我们报道了宫颈鳞状细胞癌转移到皮肤的临床分析,为临床医生了解这种恶性肿瘤。
方法:对宫颈鳞癌皮肤转移患者进行回顾性分析,注重临床表现,组织病理学,诊断,治疗,和预后。
结果:6例宫颈鳞癌皮肤转移患者的平均发病年龄为55.17±17.08岁,4例为孤立性病变,2例为多发病变。治疗策略包括局部切除孤立性病变,化疗,放射治疗,或基于皮肤受累程度的靶向治疗,免疫疗法在我们的病例中被证明有希望的结果。在六名患者中,3人死亡,诊断至死亡时间约为5-6个月,三个病人还活着,生存时间从30到72个月不等。
结论:宫颈鳞状细胞癌的皮肤转移很少见,并且经常伴随着其他内脏部位的复发转移。需要早期和准确的诊断。对于孤立的转移性病变,早期发现后进行广泛切除手术和辅助放疗可获得良好的结果.然而,在多个皮肤转移或同时转移到多个器官的情况下,治疗具有挑战性,预后不良。然而,随着医学的进步,联合化疗,免疫疗法,靶向治疗能有效延长生存期,为宫颈癌皮肤转移患者带来新的希望。
BACKGROUND: Cancers that metastasize to the skin are rare, especially cervical squamous cell carcinoma to the skin. Here, we have reported clinical analysis of patients with cervical squamous cell carcinoma metastasize to skin, to obtain a general understanding of this malignancy for clinicians.
METHODS: A retrospective analysis of patients with skin metastasis from cervical squamous cell carcinoma was conducted, focusing on clinical manifestations, histopathology, diagnosis, treatment, and prognosis.
RESULTS: The average age of onset for the six patients with skin metastasis from cervical squamous cell carcinoma was 55.17±17.08 years, with four cases presenting as solitary lesions and two cases as multiple lesions. Treatment strategies included local excision for isolated lesions, chemotherapy, radiotherapy, or targeted therapy based on the extent of skin involvement, and immunotherapy was proved to have promising results in our cases. Among the six patients, three have passed away with a diagnosis-to-death time of approximately 5-6 months, while three patients are alive, with survival times ranging from 30 to 72 months.
CONCLUSIONS: Skin metastasis from cervical squamous cell carcinoma is rare and often accompanies recurrent metastases to other visceral sites, necessitating early and accurate diagnosis. For isolated metastatic lesions, early detection followed by wide excision surgery and adjuvant radiotherapy can yield favorable outcomes. However, in cases of multiple skin metastases or concurrent metastases to multiple organs, treatment is challenging with a poor prognosis. Nevertheless, with advancements in medicine, combination chemotherapy, immunotherapy, and targeted therapy can effectively prolong survival, offering new hope for patients with skin metastasis from cervical cancer.