PDF(Pubmed)
Abstract：
Background: In recent years, abnormalities in plasma omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been proven to be related to the risk of cancer, but their prognostic value for cancer is unclear. The purpose of this study was to retrospectively evaluate the response and prognostic significance of plasma omega-3 PUFAs in patients with cervical squamous cell carcinoma (CSCC) treated with concurrent chemoradiotherapy (CCRT). Spearman rank correlation analysis was used to analyze the correlation between omega-3 PUFAs and squamous cell carcinoma antigen (SCC-Ag) levels. Methods: A total of 89 patients with CSCC who underwent CCRT were evaluated retrospectively. Binary logistic regression analysis was used to analyze the independent predictors related to complete response (CR) after CCRT. A Cox proportional hazard model and Kaplan-Meier analysis were utilized to perform survival analysis. Results: According to multivariate logistic regression analyses, a high level of plasma EPA was independently correlated with an increased incidence of CR after CCRT (odds ratio (OR), 0.980; 95% confidence interval (CI), 0.962-0.999, p = 0.038). With a median follow-up of 41.3 months, the CSCC patients in the high EPA (≥46.0 nmol/mL) group exhibited longer OS and PFS. According to our multivariate analysis, pretreatment plasma EPA level was an independent prognostic factor for PFS in patients with CSCC who underwent CCRT (hazard ratio (HR), 0.263; 95% CI, 0.089-0.782, p = 0.016). However, it was not an independent prognostic factor of OS. Spearman rank correlation analysis revealed was a negative correlation between pretreatment SCC-Ag (pre SCC-Ag) levels and EPA levels (r = -0.305, p = 0.004), and a weak negative correlation between posttreatment SCC-Ag (post SCC-Ag) levels and EPA levels (r = -0.251, p = 0.018). Conclusion: Plasma omega-3 PUFAs are related to the response and survival outcome of patients with CSCC who underwent CCRT. Pretreatment plasma EPA levels may be a promising biomarker for predicting the response and prognosis of patients with CSCC who undergo CCRT. In addition, the pretreatment plasma EPA levels presented a negative correlation with the SCC-Ag levels.
摘要：
背景：近年来，血浆omega-3多不饱和脂肪酸（omega-3PUFA）异常已被证明与癌症风险有关，但它们对癌症的预后价值尚不清楚.这项研究的目的是回顾性评估血浆omega-3PUFA在接受同步放化疗（CCRT）治疗的宫颈鳞状细胞癌（CSCC）患者中的反应和预后意义。采用Spearman秩相关分析omega-3PUFAs与鳞状细胞癌抗原(SCC-Ag)水平的相关性。方法：对89例接受CCRT的CSCC患者进行回顾性分析。采用二元logistic回归分析CCRT后与完全缓解（CR）相关的独立预测因子。采用Cox比例风险模型和Kaplan-Meier分析进行生存分析。结果：根据多变量逻辑回归分析，高水平的血浆EPA与CCRT后CR的发生率增加独立相关(比值比(OR),0.980；95%置信区间(CI)，0.962-0.999，p=0.038）。中位随访时间为41.3个月，高EPA(≥46.0nmol/mL)组的CSCC患者表现出较长的OS和PFS.根据我们的多变量分析，治疗前血浆EPA水平是接受CCRT的CSCC患者PFS的独立预后因素（风险比（HR），0.263；95%CI，0.089-0.782，p=0.016）。然而,它不是OS的独立预后因素。Spearman秩相关分析显示，治疗前SCC-Ag（preSCC-Ag）水平和EPA水平呈负相关（r=-0.305，p=0.004），治疗后SCC-Ag（postSCC-Ag）水平与EPA水平之间呈弱负相关（r=-0.251，p=0.018）。结论：血浆omega-3PUFAs与CCRT患者的反应和生存结局有关。预处理血浆EPA水平可能是预测接受CCRT的CSCC患者的反应和预后的有希望的生物标志物。此外,治疗前血浆EPA水平与SCC-Ag水平呈负相关.
