■通过空气空间传播(STAS)是肺癌传播的多种模式之一,然而,其分子和临床病理特征仍然缺乏研究。本研究旨在探讨黏附分子表达水平对Ⅰ期肺癌根治术患者STAS发生率及术后复发的影响。
■E-cadherin,P-cadherin,N-钙黏着蛋白,粘着斑激酶(FAK),上皮细胞粘附分子(EpCAM),神经细胞粘附分子1(NCAM1),血管细胞粘附分子1(VCAM1),我们采用免疫组织化学方法对I期非小细胞肺癌(NSCLC)行根治性切除术患者的细胞间粘附分子-1(ICAM-1)进行回顾性分析.根据粘附分子表达水平将患者分为四组:“低/低”,\"高/低\",\"低/高\",和“高/高”,无复发概率(RFP)最低的组定义为高危人群.使用卡方检验和逻辑回归模型确定这些粘附分子的表达水平与STAS之间的关联。采用对数秩检验和Cox比例风险模型对RFP进行分析。
■截至2024年1月1日,接受I期肺癌根治术的60例患者中有12例复发。对所有60例患者的组织标本进行回顾性分析,STAS阳性(n=30)和STAS阴性(n=30)患者的基线临床病理特征没有显着差异,除了组织学生长模式。我们发现E-cadherin的低表达,N-cadherin和FAK的高表达,男性是STAS发病率较高的独立预测因子。多因素Cox分析显示低E-cadherin/高N-cadherin,低E-钙黏着蛋白/高FAK,高N-cadherin/高FAK表达是I期肺癌患者复发的重要预测因子。此外,女性和高N-cadherin/高FAK与STAS患者的高复发风险相关.
■E-cadherin,N-钙黏着蛋白,和FAK是I期NSCLC中STAS发生的预测因子,它们的组合是预后因素。这些分子标志物的发现为临床医生提供了一种可靠的方法,可能有助于早期识别肺癌患者复发风险较高的个体。针对个性化治疗计划,如积极辅助治疗或密切随访。
UNASSIGNED: Spread through air spaces (STAS) is one of the multiple modes of lung cancer dissemination, yet its molecular and clinicopathological characterization remains poorly studied. This study aimed to investigate the effect of adhesion molecule expression levels on the incidence of STAS and postoperative recurrence in stage I lung cancer patients undergoing radical resection.
UNASSIGNED: E-cadherin, P-cadherin, N-cadherin, focal adhesion kinase (FAK), epithelial cell adhesion molecule (EpCAM), neural cell adhesion molecule 1 (NCAM1), vascular cell adhesion molecule 1 (VCAM1), intercellular cell adhesion molecule-1 (ICAM-1) were analyzed retrospectively using immunohistochemistry in patients undergoing radical resection for stage I non-small cell lung cancer (NSCLC). Patients were categorized into four groups based on adhesion molecule expression levels: \"low/low\", \"high/low\", \"low/high\", and \"high/high\", and the group with the lowest recurrence-free probability (RFP) was defined as high risk. Associations between those adhesion molecules\' expression levels and STAS were determined by using the Chi-squared test and logistic regression model. RFP was analyzed by using the log-rank test and Cox proportional risk model.
UNASSIGNED: As of January 1, 2024, 12 of 60 patients undergoing radical resection for stage I lung carcinoma had a disease recurrence. All 60 patients\' tissue specimens were retrospectively analyzed, and there were no significant differences between patients with STAS-positive (n=30) and STAS-negative (n=30) in baseline clinicopathologic features, except for histological growth patterns. We found that low expression of E-cadherin, high expression of N-cadherin and FAK, and males were independent predictors of higher incidence of STAS. Multivariate Cox analysis showed that tumors with low E-cadherin/high N-cadherin, low E-cadherin/high FAK, and high N-cadherin/high FAK expression were important predictors of recurrence in patients with stage I lung carcinoma. In addition, females and high N-cadherin/high FAK were associated with a high risk of recurrence in patients with STAS.
UNASSIGNED: E-cadherin, N-cadherin, and FAK are predictors of STAS occurrence in stage I NSCLC, and their combinations are prognostic factors. The discovery of these molecular markers provides clinicians with a reliable means that may help in the early identification of individuals with a higher risk of recurrence in lung cancer patients, targeting personalized treatment plans such as aggressive adjuvant therapy or closer follow-up.