这项研究的目的是确定有氧运动对颈动脉至股动脉脉搏波速度(cf-PWV)的影响,细胞粘附分子(细胞内粘附分子(ICAM-1),血管细胞粘附分子(VCAM-1),内皮选择素(E-选择素),和氧化低密度脂蛋白在70-85岁的老年妇女,并确定血管僵硬的影响和相关性。招募了40名参与者,并将其分为三组;血管僵硬度(VSG,n=14),肥胖(OG,n=14),和正常(NG,n=12)。两组均进行为期16周的有氧运动干预,使用SPSSVer对运动前后收集的数据进行分析。23.0.双向重复测量方差分析用于评估组间和时间依赖性相互作用效应。使用单因素方差分析评估组间差异。此外,使用事后检验(Scheffe)检验显著性。使用配对t检验检查运动前后随时间的组内变化,采用Pearson相关系数进行相关性分析。对显示显著差异的变量进行简单回归分析。结果表明CF-PWV的交互效应(p<0.001),VCAM-1(p<0.01),E-选择素(p<0.05),和氧化LDL(p<0.001)。cf-PWV的变化率与VCAM-1(r=0.352,p<0.05)和氧化LDL(r=0.325,p<0.05)呈正相关,具有统计学意义。为了确定cf-PWV变化率对VCAM-1变化率的影响,对变量进行了测试,回归分析中的决定系数为0.124,表明12.4%的被测变量符合标准回归线。还测试了cf-PWV变化率对氧化LDL变化率的影响的变量,回归分析中的决定系数为0.106,表明10.6%的被测变量符合标准回归线。因此,16周定期和一致的有氧运动计划对CF-PWV有显著影响,ICAM-1,VCAM-1,E-选择素,和氧化低密度脂蛋白在老年韩国女性血管僵硬,提示血管僵硬的改善,在此基础上,预测干预有助于通过降低动脉粥样硬化引起的心血管疾病的风险来预防血管功能障碍,以及在预防血管内皮细胞受损方面具有积极作用。
The purpose of this study was to determine the effects of aerobic exercise on carotid to femoral pulse wave velocity (cf-PWV), cell adhesion molecules (intracellular adhesion molecules (ICAM-1), vascular cell adhesion molecules (VCAM-1), endothelial selectin (E-selectin), and oxidized LDL in elderly women aged 70-85 years, and to identify the effect of and correlation with vascular stiffness. Forty participants were recruited and divided into three groups; vascular stiffness (VSG, n = 14), obesity (OG, n = 14), and normal (NG, n = 12). All groups were given a 16-week intervention of aerobic exercise, and the data collected before and after exercise were analyzed using SPSS Ver. 23.0. Two-way repeated-measures ANOVA was used to evaluate between-group and time-dependent interaction effects. One-way ANOVA was used to evaluate between-group variations. In addition, the significance was tested using a post hoc test (Scheffe). The within-group variations by time before and after exercise were examined using a paired t-test, and correlation analysis was performed using Pearson correlation coefficients. Simple regression analysis was performed for variables showing significant differences. The results indicate interaction effects for cf-PWV (p < 0.001), VCAM-1 (p < 0.01), E-selectin (p < 0.05), and oxidized LDL (p < 0.001). The rate of change of cf-PWV was positively correlated with that of VCAM-1 (r = 0.352, p < 0.05) and that of oxidized LDL (r = 0.325, p < 0.05) with statistical significance. To determine the effect of the rate of change of cf-PWV on the rate of change of VCAM-1, the variables were tested, and the coefficient of determination in the regression analysis was 0.124, indicating that 12.4% of the tested variables fit the standard regression line. The variables for the effect of the rate of change of cf-PWV on the rate of change of oxidized LDL were also tested, and the coefficient of determination in the regression analysis was 0.106, indicating that 10.6% of the tested variables fit the standard regression line. Thus, the 16-week regular and consistent aerobic exercise program had significant effects on the cf-PWV, ICAM-1, VCAM-1, E-selectin, and oxidized LDL in elderly Korean women with vascular stiffness, suggesting improvements in vascular stiffness, based on which the intervention is predicted to contribute to the prevention of vascular dysfunction by lowering the risk of cardiovascular disease due to atherosclerosis, as well as having a positive effect in the prevention of impairment of vascular endothelial cells.