BACKGROUND: The learning objectives in the current cross-sectional subject \"Rehabilitation, Physical Medicine, Naturopathic Medicine\" have been revised as part of the further development of the National Competency-Based Catalogue of Learning Objectives for Medicine (NKLM) to its new version 2.0. Since the NKLM is designed as an interdisciplinary catalogue, a subject assignment seemed necessary from the point of view of various stakeholders. Thus, the German Association of Scientific Medical Societies (AWMF) and the German medical faculties initiated a subject assignment process. The assignment process for the subject \"Physical and Rehabilitative Medicine, Naturopathic Medicine\" (PRM-NHV; according to the subject list of the first draft of the planned novel medical license regulations from 2020) is presented in this paper.
METHODS: The AWMF invited its member societies to participate in the assignment of learning objectives of chapters VI, VII, and VIII of the NKLM 2.0 to the individual subjects to which they consider to contribute in teaching. For \"PRM-NHV\", representatives of the societies for rehabilitation sciences (DGRW), physical and rehabilitation medicine (DGPRM), orthopaedics and traumatology (DGOU), as well as for naturopathy (DGNHK) participated. In a structured consensus process according to the DELPHI methodology, the learning objectives were selected and consented. Subsequently, subject recommendations were made by the AWMF for each learning objective.
RESULTS: From the NKLM 2.0, a total of 100 competency-based learning objectives of chapters VII and VIII for the subject \"PRM-NHV\" were consented by the representatives of the involved societies for presentation on the NKLM 2.0 online platform.
CONCLUSIONS: In the context of the revision process of medical studies in Germany and under the umbrella of the AWMF and the German medical faculties, a broad consensus of competency-based learning objectives in the subject \"PRM-NHV\" could be achieved. This provides an important orientation for all medical faculties both for the further development of teaching in the cross-sectional subject \"Rehabilitation, Physical Medicine, Naturopathic Medicine\" according to the 9th revision of the medical license regulations, which has been valid for twenty years, and for the preparation of the corresponding subjects in the draft bill of the novel license regulations.
UNASSIGNED: Im Rahmen der Weiterentwicklung des Nationalen Kompetenzbasierten Lernzielkatalogs (NKLM) zur Version 2.0 erfolgte auch eine Überarbeitung der Lernziele im bisherigen Querschnittsfach „Rehabilitation, Physikalische Medizin, Naturheilverfahren“. Da der NKLM grundsätzlich fächerübergreifend angelegt ist, von verschiedenen Seiten aber eine Fächerzuordnung notwendig schien, initiierten die Arbeitsgemeinschaft wissenschaftlich-medizinischer Fachgesellschaften (AWMF) und der Medizinische Fakultätentag einen Fächerzuordnungsprozess. Der Zuordnungsprozess für das Fach „Physikalische und Rehabilitative Medizin, Naturheilverfahren“ (PRM-NHV; laut Fächerliste des ersten Referentenentwurfes der geplanten Approbationsordnung aus dem Jahr 2020) wird in dieser Arbeit dargestellt.
UNASSIGNED: Die AWMF lud ihre Mitgliedsgesellschaften ein, sich an der Zuordnung von Lernzielen der Kapitel VI, VII und VIII des NKLM 2.0 zu den einzelnen Fächern zu beteiligen, zu denen sie nach eigener Einschätzung einen Beitrag in der Lehre leisten. Für „PRM-NHV“ beteiligten sich Vertreter*innen der DGRW, DGPRM, DGOU sowie der DGNHK. In einem strukturierten Konsensprozess nach der DELPHI-Methodik erfolgten Auswahl und Konsentierung der Lernziele. Anschließend erfolgte durch die AWMF eine Fächerempfehlung.
UNASSIGNED: Aus dem NKLM 2.0 wurden insgesamt 100 kompetenzbasierte Lernziele der Kapitel VII und VIII für das Fach „PRM-NHV“ von den Vertreter*innen der beteiligten Fachgesellschaften zur Darstellung auf der NKLM 2.0-Online-Plattform konsentiert.
UNASSIGNED: Im Rahmen des grundlegend geplanten Reformprozesses des Medizinstudiums und unter dem Dach der AWMF und des Medizinischen Fakultätentags gelang die breite Konsentierung von Lernzielen des NKLM 2.0 für die kompetenzbasierte Lehre im Fach „PRM-NHV“ durch die beteiligten Fachgesellschaften. Damit wird eine für alle medizinischen Fakultäten wichtige Orientierung sowohl für die Weiterentwicklung der Lehre im Querschnittsbereich „Rehabilitation, Physikalische Medizin, Naturheilverfahren“ gemäß der seit zwanzig Jahren gültigen 9. Revision der ÄApprO als auch für die Vorbereitung der entsprechenden Fächer im Referentenentwurf der neuen ÄApprO gegeben.

Deciphering the fine-scale molecular mechanisms that shape the genetic effects at disease-associated loci from genome-wide association studies (GWAS) remains challenging. The key avenue is to identify the essential molecular phenotypes that mediate the causal variant and disease under particular biological conditions. Therefore, integrating GWAS signals with context-specific quantitative trait loci (QTLs) (such as different tissue/cell types, disease states, and perturbations) from extensive molecular phenotypes would present important strategies for full understanding of disease genetics. Via persistent curation and systematic data processing of large-scale human molecular trait QTLs (xQTLs), we updated our previous QTLbase database (now QTLbase2, http://mulinlab.org/qtlbase) to comprehensively analyze and visualize context-specific QTLs across 22 molecular phenotypes and over 95 tissue/cell types. Overall, the resource features the following major updates and novel functions: (i) 960 more genome-wide QTL summary statistics from 146 independent studies; (ii) new data for 10 previously uncompiled QTL types; (iii) variant query scope expanded to fit 195 QTL datasets based on whole-genome sequencing; (iv) supports filtering and comparison of QTLs for different biological conditions, such as stimulation types and disease states; (v) a new linkage disequilibrium viewer to facilitate variant prioritization across tissue/cell types and QTL types.

The European Search Catalogue for Plant Genetic Resources (EURISCO) is a central entry point for information on crop plant germplasm accessions from institutions in Europe and beyond. In total, it provides data on more than two million accessions, making an important contribution to unlocking the vast genetic diversity that lies deposited in >400 germplasm collections in 43 countries. EURISCO serves as the reference system for the Plant Genetic Resources Strategy for Europe and represents a significant approach for documenting and making available the world\'s agrobiological diversity. EURISCO is well established as a resource in this field and forms the basis for a wide range of research projects. In this paper, we present current developments of EURISCO, which is accessible at http://eurisco.ecpgr.org.

Type specimens of Staphylinidae (Coleoptera) from the collection of J.H. Hochhuth (18101872) deposited in National Museum of Natural History of the National Academy of Sciences of Ukraine (Kyiv) are currently being catalogued and illustrated. This catalogue presents information about 103 type specimens (14 holotypes, 80 lecto- and paratypes, and nine syntypes) belonging to 67 nominal species. Several lectotypes are designated: Conurus erythrocephalus Hochhuth, 1849, Aleochara solida Hochhuth, 1849, Trogophloeus kiesenwetterii Hochhuth, 1851, Ocypus pullus Hochhuth, 1849, Philonthus armeniacus Hochhuth, 1851, P. interpunctatus Hochhuth, 1860, and P. subopacus Hochhuth, 1851.

Wearable technologies play an important role in measuring physical activity (PA) and promoting health. Standardized validation indices (i.e., accuracy, bias, and precision) compare performance of step counting wearable technologies in young people.
To produce a catalog of validity indices for step counting wearable technologies assessed during different treadmill speeds (slow [0.8-3.2 km/h], normal [4.0-6.4 km/h], fast [7.2-8.0 km/h]), wear locations (waist, wrist/arm, thigh, and ankle), and age groups (children, 6-12 years; adolescents, 13-17 years; young adults, 18-20 years).
One hundred seventeen individuals (13.1 ± 4.2 years, 50.4% female) participated in this cross-sectional study and completed 5-min treadmill bouts (0.8 km/h to 8.0 km/h) while wearing eight devices (Waist: Actical, ActiGraph GT3X+, NL-1000, SW-200; Wrist: ActiGraph GT3X+; Arm: SenseWear; Thigh: activPAL; Ankle: StepWatch). Directly observed steps served as the criterion measure. Accuracy (mean absolute percentage error, MAPE), bias (mean percentage error, MPE), and precision (correlation coefficient, r; standard deviation, SD; coefficient of variation, CoV) were computed.
Five of the eight tested wearable technologies (i.e., Actical, waist-worn ActiGraph GT3X+, activPAL, StepWatch, and SW-200) performed at < 5% MAPE over the range of normal speeds. More generally, waist (MAPE = 4%), thigh (4%) and ankle (5%) locations displayed higher accuracy than the wrist location (23%) at normal speeds. On average, all wearable technologies displayed the lowest accuracy across slow speeds (MAPE = 50.1 ± 35.5%), and the highest accuracy across normal speeds (MAPE = 15.9 ± 21.7%). Speed and wear location had a significant effect on accuracy and bias (P < 0.001), but not on precision (P > 0.05). Age did not have any effect (P > 0.05).
Standardized validation indices focused on accuracy, bias, and precision were cataloged by speed, wear location, and age group to serve as important reference points when selecting and/or evaluating device performance in young people moving forward. Reduced performance can be expected at very slow walking speeds (0.8 to 3.2 km/h) for all devices. Ankle-worn and thigh-worn devices demonstrated the highest accuracy. Speed and wear location had a significant effect on accuracy and bias, but not precision.
Clinicaltrials.gov NCT01989104 . Registered November 14, 2013.

Bacteriophages have important roles in the ecology of the human gut microbiome but are under-represented in reference databases. To address this problem, we assembled the Metagenomic Gut Virus catalogue that comprises 189,680 viral genomes from 11,810 publicly available human stool metagenomes. Over 75% of genomes represent double-stranded DNA phages that infect members of the Bacteroidia and Clostridia classes. Based on sequence clustering we identified 54,118 candidate viral species, 92% of which were not found in existing databases. The Metagenomic Gut Virus catalogue improves detection of viruses in stool metagenomes and accounts for nearly 40% of CRISPR spacers found in human gut Bacteria and Archaea. We also produced a catalogue of 459,375 viral protein clusters to explore the functional potential of the gut virome. This revealed tens of thousands of diversity-generating retroelements, which use error-prone reverse transcription to mutate target genes and may be involved in the molecular arms race between phages and their bacterial hosts.

The reconstruction of bacterial and archaeal genomes from shotgun metagenomes has enabled insights into the ecology and evolution of environmental and host-associated microbiomes. Here we applied this approach to >10,000 metagenomes collected from diverse habitats covering all of Earth\'s continents and oceans, including metagenomes from human and animal hosts, engineered environments, and natural and agricultural soils, to capture extant microbial, metabolic and functional potential. This comprehensive catalog includes 52,515 metagenome-assembled genomes representing 12,556 novel candidate species-level operational taxonomic units spanning 135 phyla. The catalog expands the known phylogenetic diversity of bacteria and archaea by 44% and is broadly available for streamlined comparative analyses, interactive exploration, metabolic modeling and bulk download. We demonstrate the utility of this collection for understanding secondary-metabolite biosynthetic potential and for resolving thousands of new host linkages to uncultivated viruses. This resource underscores the value of genome-centric approaches for revealing genomic properties of uncultivated microorganisms that affect ecosystem processes.

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A novel two-dimensional matrix taxonomy, or atlas, of personality, emotion and behaviour is presented. The two dimensions of the atlas, affiliation and dominance, are demonstrated to have theoretical foundations in neurobiology and social psychology. Both dimensions are divided into five ordinal categories, creating a square matrix of 25 cells. A new catalogue of 20,669 English words descriptive of personality, emotion, behaviour, and power is also presented. The catalogue is more comprehensive than previous catalogues, and is novel in its inclusion of intrapersonal, group, and societal behaviours. All words in the catalogue were scored according to the atlas, facilitating visualisation in two dimensions. This enabled a contiguous and novel comparison of existing psychological taxonomies, as well as broader societal concepts such as leadership, ethics, and crime. Using the atlas, a novel psychological test is developed with improved sensitivity and specificity.

Daily rhythms of physiology, metabolism, and behavior are orchestrated by a central circadian clock. In mice, this clock is coordinated by the suprachiasmatic nucleus, which consists of 20,000 neurons, making it challenging to characterize individual neurons. In Drosophila, the clock is controlled by only 150 clock neurons that distribute across the fly\'s brain. Here, we describe a comprehensive set of genetic drivers to facilitate individual characterization of Drosophila clock neurons. We screened GAL4 lines that were obtained from Drosophila stock centers and identified 63 lines that exhibit expression in subsets of central clock neurons. Furthermore, we generated split-GAL4 lines that exhibit specific expression in subsets of clock neurons such as the 2 DN2 neurons and the 6 LPN neurons. Together with existing driver lines, these newly identified ones are versatile tools that will facilitate a better understanding of the Drosophila central circadian clock.