背景:汗腺癌是一种罕见的恶性汗腺肿瘤,以缓慢但激进的过程为特征,局部复发和转移率高。由于它的稀有性,组织学标准和治疗指南定义不明确,对临床医生和病理学家构成重大挑战。
目的:介绍两例新的转移性腺癌病例并进行文献复习。
方法:我们描述了两个案例研究,并基于使用MEDLINE(PubMed)电子数据库的搜索对文献进行了综述。
结果:首例患者是一名61岁的女性,患有乳周腺癌,该腺癌起因于儿童期良性病变的恶性转化,并在广泛切除和辅助放疗后发生区域淋巴结转移。第二名患者是一名63岁的男子,他在完全切除腰椎腺癌后几年出现了皮肤和肾脏转移。据我们所知,以前从未描述过癌的肾转移。
结论:大多数作者推荐广泛切除作为癌腺癌的治疗选择,然而,最佳辅助治疗还有待确定.我们的案例增加了可用的有限知识,但是需要高质量的研究来寻找新的有效治疗方法。
BACKGROUND: Hidradenocarcinoma is a rare malignant sweat gland tumour, characterized by a slow but aggressive course, with high rates of local recurrence and metastasis. Due to its rarity, histological criteria and therapeutic guidelines are poorly defined, posing a major challenge for clinicians and pathologists.
OBJECTIVE: To present two new cases of metastatic hidradenocarcinoma as well as a review of the literature.
METHODS: We describe two case studies and a review of the literature based on a search using the MEDLINE (PubMed) electronic database.
RESULTS: The first patient was a 61-year-old woman with a perimamillary hidradenocarcinoma that arose from the malignant transformation of a benign childhood lesion and developed regional lymph node metastases after wide excision and adjuvant radiotherapy. The second patient was a 63-year-old man who developed cutaneous and renal metastases several years after the complete excision of a lumbar hidradenocarcinoma. As far as we can ascertain, kidney metastasis from hidradenocarcinoma has not previously been described.
CONCLUSIONS: Most authors recommend wide excision as the treatment of choice for hidradenocarcinoma, however, optimal adjuvant therapy remains to be determined. Our cases add to the limited knowledge available, but high-quality studies to find new effective treatments are needed.