副肿瘤神经综合征是指某些恶性肿瘤在没有肿瘤转移的情况下,已经影响到远端神经系统并导致相应的功能障碍。患有这种综合征的患者会产生多种抗体,每个靶向不同的抗原并引起不同的症状和体征。CV2/折叠素反应介质蛋白5(CRMP5)抗体是这种类型的主要抗体。它会损害神经系统,通常表现为边缘叶脑炎,舞蹈病,眼部表现,小脑共济失调,脊髓病,和周围神经病变。检测CV2/CRMP5抗体对临床诊断神经系统副肿瘤综合征至关重要,抗肿瘤和免疫疗法有助于缓解症状和改善预后。然而,由于这种疾病的发病率低,到目前为止,关于它的报道很少,评论也没有发表。本文拟对CV2/CRMP5抗体相关副肿瘤神经综合征的研究进行综述,总结其临床特点,以帮助临床医师全面了解该病。此外,这篇综述讨论了这种疾病带来的当前挑战,以及新的检测和诊断技术在副肿瘤神经综合征领域的应用前景,包括CV2/CRMP5相关的副肿瘤神经综合征,近年来。
Paraneoplastic neurological syndrome refers to certain malignant tumors that have affected the distant nervous system and caused corresponding dysfunction in the absence of tumor metastasis. Patients with this syndrome produce multiple antibodies, each targeting a different antigen and causing different symptoms and signs. The
CV2/collapsin response mediator protein 5 (CRMP5) antibody is a major antibody of this type. It damages the nervous system, which often manifests as limbic encephalitis, chorea, ocular manifestation, cerebellar ataxia, myelopathy, and peripheral neuropathy. Detecting
CV2/CRMP5 antibody is crucial for the clinical diagnosis of paraneoplastic neurological syndrome, and anti-tumor and immunological therapies can help to alleviate symptoms and improve prognosis. However, because of the low incidence of this disease, few reports and no reviews have been published about it so far. This article intends to review the research on
CV2/CRMP5 antibody-associated paraneoplastic neurological syndrome and summarize its clinical features to help clinicians comprehensively understand the disease. Additionally, this review discusses the current challenges that this disease poses, and the application prospects of new detection and diagnostic techniques in the field of paraneoplastic neurological syndrome, including
CV2/CRMP5-associated paraneoplastic neurological syndrome, in recent years.