关键词: CRMP5 CV2 case report choreoathetosis paraneoplastic

Mesh : Heart Arrest / complications Humans Hydrolases Lung Neoplasms Male Microtubule-Associated Proteins Paraneoplastic Syndromes / complications

来  源:   DOI:10.1080/13554794.2020.1866615   PDF(Sci-hub)

Abstract:
CV2/CRMP5 is the most common antibody accompaniment of paraneoplastic choreoathetosis. We present a case of paraneoplastic choreothetosis with associated cerebellar dysfunction, peripheral neuropathy, and likely dysautonomia. Our patient developed a movement disorder after a cardiopulmonary arrest, which unfortunately masked the true etiology of his symptoms. He was later found to have extensive stage small cell lung cancer, with further evaluation revealing seropositivity for anti-CV2 antibodies. Choreoathetosis is a known sequelae of hypoxic-ischemic brain injury, but clinicians should continue to keep an open mind. The utility of immunotherapy is unclear in these circumstances and many physicians adopt a symptom-based approach.
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