目的:比较两种新型含SnF2洁牙剂在盲剂中的再矿化功效和离子生物利用度,cross-over,随机原位临床研究。
方法:6名参与者佩戴去除腭矫治器,持有带有表面下病变的人牙釉质和牙本质块。每次连续14天佩戴两个治疗期的矫正器,中间有一周的冲洗期。参与者被随机分配使用两种洁齿剂中的一种1:5稀释的编码浆液进行冲洗,该洁齿剂含有5%酪蛋白磷酸肽-无定形磷酸钙(CPP-ACP)+1100ppmF作为SnF2[MIPOP],或1100ppmF作为SnF2[CT],1分钟,一天四次.治疗后收集唾液并分析锡,钙,无机磷酸盐和氟化物离子采用原子吸收分光光度法和离子色谱法。使用横向显微放射术和表面显微硬度恢复百分比(%SMHR)分析牙釉质和牙本质病变的再矿化百分比(%R)。
结果:MIPOP释放出较高的F(3.00±0.27mM),Ca(15.23±3.23mM)和Sn(1.18±0.13mM)进入唾液,而CT释放2.89±0.32mMF,仅释放0.84±0.11mMCa和0.28±0.10mMSn。MIPOP产生的%R显著高于CT:25.6±1.5%,牙釉质为15.2±0.7%,牙本质为33.6±3.1%,牙本质为20.6±1.1%。此外,与CT(4.1±0.6%)相比,MIPOP产生显著更高的%SMHR(18.2±7.9%)。
结论:两种洁牙剂都能促进再矿化,但是添加了CPP-ACP和CPP的离子稳定作用的MIPOP洁齿剂释放了更大量的生物可利用锡,并产生了显着更高的再矿化和表面显微硬度恢复。
结论:现代洁牙剂含有SnF2,具有一系列口腔健康益处。与这些制剂的稳定性相关的挑战会影响离子的生物利用度。降低功效。两种含SnF2的洁齿剂促进原位再矿化,然而,添加了唾液仿生CPP-ACP的洁齿剂更优,因此可能产生更大的健康益处.
To compare the remineralisation efficacy and ion bioavailability of two novel SnF2-containing dentifrices in a blinded, cross-over, randomised in situ clinical study.
Six participants wore removal palatal appliances holding human enamel and dentine blocks with subsurface lesions. Appliances were worn for two treatment periods of 14 consecutive days each, with a one-week washout period in-between. Participants were randomly allocated to rinse with a 1:5 diluted coded slurry of one of two dentifrices containing either 5 % casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) +1100 ppm F as SnF2 [MIPOP], or 1100 ppm F as SnF2 [CT], for 1 min, four times a day. Saliva was collected post-treatment and analysed for tin, calcium, inorganic phosphate and fluoride ions using atomic absorption spectrophotometry and ion chromatography. Enamel and dentine lesions were analysed for percent remineralisation (%R) using transverse microradiography and percent surface microhardness recovery (%SMHR).
MIPOP released significantly higher F (3.00 ± 0.27 mM), Ca (15.23 ± 3.23 mM) and Sn (1.18 ± 0.13 mM) into saliva whereas CT released 2.89 ± 0.32 mM F and only 0.84 ± 0.11 mM Ca and 0.28 ± 0.10 mM Sn. MIPOP produced significantly higher %R than CT: 25.6 ± 1.5 % compared to 15.2 ± 0.7 % in enamel, and 33.6 ± 3.1 % compared to 20.6 ± 1.1 % in dentine. Additionally, MIPOP produced significantly higher %SMHR (18.2 ± 7.9 %) compared to CT (4.1 ± 0.6 %).
Both dentifrices promoted remineralisation, but the MIPOP dentifrice with added CPP-ACP and the ion-stabilising effects of CPP released higher amounts of bioavailable tin and produced significantly higher remineralisation and surface microhardness recovery.
Modern dentifrices contain SnF2 for a range of oral health benefits. Challenges associated with stability of these formulations can affect ion bioavailability, reducing efficacy. Two dentifrices with SnF2 promoted remineralisation in situ, however the dentifrice with the added saliva biomimetic CPP-ACP was superior and therefore may produce greater health benefits.