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  • 文章类型: Journal Article
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    文章类型: Journal Article
    目的:该项目的目的是调查北美小儿骨科学会(POSNA)成员关于胫骨前肌腱转移(TATT)在复发性马蹄内翻足的治疗中的应用。我们旨在评估儿科骨科医生最常用的TATT技术。由于文献中没有关于最佳方法的普遍共识,我们假设POSNA成员的治疗方法差异很大.
    方法:在线调查,使用研究电子数据采集(REDCap)调查软件设计,由15个初始问题组成,其中一些有条件的后续问题,如果受访者选择了特定的答案选择,就会出现,总共有22个问题。该调查已获得POSNA循证实践委员会的批准,并分发给其1,370名成员。
    结果:分析中只包括治疗马蹄内翻足并执行TATT的POSNA成员的反应。228名调查受访者就少数主题达成共识(75%同意):马蹄内翻足使用Ponseti治疗方法(94%),胫骨前肌腱转移到外侧楔形文字(77%),仅转移整个胫骨前肌腱(79%),以及在报告使用术后矫正器的人中使用踝足矫形器(94%)。然而,其余的调查问题表明,TATT的性能存在明显的差异。
    结论:许多问题得到了不同的回答,这表明POSNA成员对如何以及何时对患有动态旋涡且无畸形的复发性马蹄内翻足进行TATT的不同意见。这是有关TATT治疗变化的第一批信息汇编之一,可能会导致进一步的研究,以检查标准化和优化其使用的方法。
    OBJECTIVE: The aim of this project was to survey members of the Pediatric Orthopaedic Society of North America (POSNA) regarding the use of tibialis anterior tendon transfer (TATT) in the management of recurrent clubfoot with dynamic supination and no deformity. We aimed to assess which techniques for TATT are most utilized by pediatric orthopedists. As there has been no general consensus in the literature regarding best methods, we hypothesized that treatment methods would vary widely among POSNA members.
    METHODS: The online survey, designed using Research Electronic Data Capture (REDCap) survey software, consisted of 15 initial questions, some of which had conditional follow-up questions that appeared if the respondent selected a specific answer choice, with a potential total of 22 questions. The survey was approved by the Evidence Based Practice Committee of POSNA and distributed to their 1,370 members.
    RESULTS: Only the responses of POSNA members who treated clubfoot and performed TATT were included in the analysis. The 228 survey respondents reached a consensus (75% agreement) on a small number of topics: use of the Ponseti treatment method for clubfoot (94%), transfer of the tibialis anterior tendon to the lateral cuneiform (77%), transfer of only the whole tibialis anterior tendon (79%), and the use of an ankle foot orthoses (94%) among those who reported using postoperative braces. However, the remaining survey questions revealed a marked amount of variability in the performance of TATT.
    CONCLUSIONS: Many of the questions garnered varied responses, which suggests differing opinions of POSNA members regarding how and when TATT should be performed for recurrent clubfoot with dynamic supination and no deformity. This is one of the first compilations of information about the treatment variations for TATT and may lead to further studies examining ways to standardize and optimize its use.
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  • 文章类型: Journal Article
    目的:青光眼是全球主要的公共卫生问题。本摘要讨论了青光眼筛查的障碍和具有成本效益的青光眼筛查的新策略。
    结果:我们讨论了青光眼筛查的障碍以及青光眼检测和护理的最新进展,包括有针对性的筛查方法以及远程医疗,基因检测,人工智能(AI)。青光眼筛查的主要障碍是由于疾病的低患病率和诊断的复杂性而导致的病例发现的成本效益。有针对性的筛查,以及多层次的筛查,可以降低假阳性率,提高方案的成本效益。远程医疗,基因检测和多基因风险评分的可用性,人工智能为初级保健中的新型青光眼筛查计划提供了机会,便携式,和基于家庭的设置,将有助于降低成本,确定需要紧急治疗的患者,并及时诊断和早期干预。
    结论:青光眼筛查具有挑战性和变化性。数字技术和遗传学的最新进展导致了有希望用于新型筛查方法的工具的开发。需要临床试验来证明靶向筛查对全球青光眼负担的长期影响。
    OBJECTIVE: Glaucoma is a leading public health concern globally. This summary discusses barriers to glaucoma screening and novel strategies for a cost-effective glaucoma screening.
    RESULTS: We discuss barriers to glaucoma screening and recent advancements in glaucoma detection and care, including targeted screening approach as well as telemedicine, genetic testing, and artificial intelligence (AI). A major barrier to glaucoma screening is the cost-effectiveness of case finding resulting from the low prevalence of the disease and the complexity of the diagnosis. Targeted-screening, as well as multi-level screening, can reduce the false positive rate and increase the cost-effectiveness of the program. Telemedicine, availability of genetic testing and polygenic risk scores, and AI provide the opportunity for novel glaucoma screening programs in primary care, portable, and home-based settings and will be helpful for lowering the costs, identifying patients in need of urgent treatment and enabling timely diagnosis and early intervention.
    CONCLUSIONS: Screening of glaucoma is challenging and changing. Recent advancements in digital technology and genetics have led to the development of tools that are promising for novel screening methodologies. Clinical trials are needed to demonstrate the long-term effect of targeted screening on the burden of glaucoma worldwide.
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  • 文章类型: Editorial
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  • 文章类型: English Abstract
    The number of elderly and senile patients who are in need of surgical care delivery is growing steadily year over year. This category of patients is characterized by comorbidity, polypragmasy and high prevalence of geriatric syndromes including loss of autonomy, malnutrition and cognitive impairments that increase the risk of developing perioperative complications. Management of these patients at all stages requires a comprehensive multidisciplinary approach. Nevertheless, there is no uniform understanding of solution of this problem at present. Determination of consensus on certain issues using the Delphi method will allow to gather and unite expert opinions. In this regard, the working group formulated the main points of management of elderly and senile patients before, during and after surgical treatment and conducted a cross-sectional analysis of experts\' opinions.
    Ежегодно число пациентов пожилого и старческого возраста, нуждающихся в оказании хирургической помощи, неуклонно растет. Данная категория пациентов характеризуется коморбидностью, полипрагмазией и высоким распространением гериатрических синдромов, включая утрату автономности, мальнутрицию и когнитивные нарушения, которые увеличивают риски развития периоперационных осложнений. Ведение этих пациентов на всех этапах требует комплексного мультидисциплинарного подхода. Однако в настоящее время нет единого понимания решения данной задачи. Достижение консенсуса по отдельным вопросам с использованием метода Дельфи позволит собрать и объединить мнение экспертов. С этой целью рабочей группой были сформулированы основные тезисы ведения пациентов пожилого и старческого возраста до, во время и после хирургического лечения и проведен поперечный срез мнений экспертов.
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  • 文章类型: Journal Article
    背景:高血压,影响全世界数百万人的慢性疾病,是心血管疾病的主要原因。需要采取多学科的方法来减轻疾病的负担,全科医生起着至关重要的作用。因此,全科医生提供标准化且基于最新欧洲指南的高质量护理至关重要.质量指标(QIs)可用于评估绩效,结果,或医疗保健交付过程,并在帮助医疗保健专业人员确定改进领域和衡量实现预期健康结果的进展方面至关重要。然而,已经在有限的程度上研究了在一般实践中评估高血压患者护理的QIs。我们研究的目的是定义一般实践中高血压的质量指标,这些质量指标可从电子健康记录(EHR)中提取,可用于评估和提高一般实践中高血压患者的护理质量。
    方法:我们使用了Rand修改的Delphi程序。我们从欧洲指南中提取了建议,并将其汇总到在线问卷中。小组成员进行了基于SMART原理和EHR可提取性的初始评分,这些结果使用李克特中位数评分进行分析,优先次序和共识程度。召开了一次协商一致的会议,讨论了所有的建议,然后是最后一轮验证。
    结果:我们的研究提取了115条建议。在分析了在线问卷轮和共识会议轮之后,37项建议被接受,75项被排除。在这37项建议中,9个被稍微修改,4个被合并为2个建议,产生了35条建议。最后一组的所有建议都被翻译成合格证明,由7个QIs组成,6QIsondiagnosis,11个QIsontreatment,关于结果的5个QIs和关于后续行动的6个QIs。
    结论:我们的研究在一般实践中得出了35个高血压的QIs。这些QIs,为比利时EHR量身定制,为自动审计和反馈提供坚实的基础,如果适应其他国家的系统,可以大大受益。
    BACKGROUND: Hypertension, a chronic medical condition affecting millions of people worldwide, is a leading cause of cardiovascular diseases. A multidisciplinary approach is needed to reduce the burden of the disease, with general practitioners playing a vital role. Therefore, it is crucial that GPs provide high-quality care that is standardized and based on the most recent European guidelines. Quality indicators (QIs) can be used to assess the performance, outcomes, or processes of healthcare delivery and are critical in helping healthcare professionals identify areas of improvement and measure progress towards achieving desired health outcomes. However, QIs to evaluate the care of patients with hypertension in general practice have been studied to a limited extent. The aim of our study is to define quality indicators for hypertension in general practice that are extractable from the electronic health record (EHR) and can be used to evaluate and improve the quality of care for hypertensive patients in the general practice setting.
    METHODS: We used a Rand-modified Delphi procedure. We extracted recommendations from European guidelines and assembled them into an online questionnaire. An initial scoring based on the SMART principle and extractability from the EHR was performed by panel members, these results were analyzed using a Median Likert score, prioritization and degree of consensus. A consensus meeting was set up in which all the recommendations were discussed, followed by a final validation round.
    RESULTS: Our study extracted 115 recommendations. After analysis of the online questionnaire round and a consensus meeting round, 37 recommendations were accepted and 75 were excluded. Of these 37 recommendations, 9 were slightly modified and 4 were combined into 2 recommendations, resulting in a list of 35 recommendations. All recommendations of the final set were translated to QIs, made up of 7 QIs on screening, 6 QIs on diagnosis, 11 QIs on treatment, 5 QIs on outcome and 6 QIs on follow-up.
    CONCLUSIONS: Our study resulted in a set of 35 QIs for hypertension in general practice. These QIs, tailored to the Belgian EHR, provide a robust foundation for automated audit and feedback and could substantially benefit other countries if adapted to their systems.
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  • 文章类型: English Abstract
    Perioperative pulmonary rehabilitation may effectively reduce the incidence of postoperative pulmonary complications and improve the quality of life of lung cancer patients and its clinical application value in lung cancer patients has been widely recognized. However, there is still no international consensus or guideline for pulmonary rehabilitation regimen, lacking standardized criteria when pulmonary rehabilitation applied in perioperative clinical practice for lung cancer. The consensus provides implementation regimen and process of pulmonary rehabilitation, aiming to promote the reasonable and standardized application of perioperative pulmonary rehabilitation training in clinical practice, sequentially enable patients to maximize benefits from the rehabilitation.
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    【中文题目:肺癌围手术期肺康复训练中国专家共识】 【中文摘要:围手术期肺康复能有效降低术后肺部相关并发症的发生并提高肺癌患者术后的生活质量,在肺癌患者中的临床应用价值已被广泛认可。然而肺康复方案仍然没有形成国际共识和指南,运用于肺癌围手术期临床实践时缺乏规范和标准。本共识将通过提供围手术期肺康复训练的实施方案、流程,促进围手术期肺康复训练在临床实践中更合理、更规范地应用,最终能够使患者最大程度地从中获益。
】 【中文关键词:肺肿瘤;围手术期肺康复;专家共识】.
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  • 文章类型: English Abstract
    The standard clinical practice of managing the non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon 20 insertion (ex20ins) mutations was elaborated in Chinese expert consensus on non‑small cell lung cancer with EGFR exon 20 insertion mutations (2023 edition), and this rare subset has gradually attracted attention recently. With the deepening of treatment area exploration and the approval of new targeted drugs, there are more options for the diagnosis and treatment of EGFR ex20ins positive NSCLC patients. Therefore, based on the previous version of consensus, the expert panel has updated this consensus on the standardized clinical diagnosis and treatment of EGFR ex20ins mutation NSCLC through reference to literature and clinical data, and combined with the experts\' own clinical experience. The updated recommendations includes disease congnition, testing methods, therapy and recent relevant clinical trials for NSCLC patients with EGFR ex20ins mutation, in order to provide better medication reference for clinical physicians.
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    【中文题目:EGFR 20外显子插入突变非小细胞肺癌
规范化诊疗中国专家共识(2024版)】 【中文摘要:表皮生长因子受体(epidermal growth factor receptor, EGFR)20外显子插入(exon 20 insertion, ex20ins)突变非小细胞肺癌(non-small cell lung cancer, NSCLC)的规范化诊疗在《EGFR 20外显子插入突变非小细胞肺癌规范化诊疗中国专家共识(2023版)》中进行了阐述,提高了临床医生对该罕见靶点的关注。随着疾病领域探索的深入及新型靶向药物的获批,EGFR ex20ins NSCLC的诊疗策略也随之更新。本共识在2023版中国专家共识的基础上进行更新,专家组通过参考国内外文献及临床数据并结合专家自身临床经验,分别从疾病认知、疾病检测、疾病治疗和新型靶向药物研发现状等方面更新共识性建议,以期更好地为临床医师提供用药参考。
】 【中文关键词:肺肿瘤;EGFR 20外显子插入突变;规范化诊疗;共识】.
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  • 文章类型: Journal Article
    背景:需要实用的社交媒体建议,以促进更多参与痴呆症预防研究。与相关专家一道,我们的目标是制定一套共识建议,反映潜在参与者的价值观和优先事项,以指导社交媒体的使用。
    方法:我们进行了三轮,修改后的Delphi由三个在线调查和三个电话会议组成。多样化,国际德尔福小组由16名专家组成,他们有生活经验(n=10)和专业经验(n=6)。共识先验定义为≥70%的一致性。
    结果:26项达成共识。在第一轮中,有两个项目达成了共识:封闭社交媒体团体的道德考虑(88%)和社交媒体用户与不在社交媒体上的联系人分享预防内容(79%)。在第二轮中,有九个项目达成共识,与错误信息有关(79%),污名(93%),以及社交媒体传播的其他关键方面。修订后,15个项目在最后一轮达成共识。这些项目包括:确定研究人员何时应该参与,管理封闭的社交媒体团体,短格式内容排名,优先考虑摘要和多媒体资源,以及首选语言的排名。关于痴呆症患者的预防语言的一项内容尚未达成共识。最后的共识项目形成了一套新的建议,我们组织了七个社交媒体用例。这些用例包括建立社交媒体页面或社区,处理网上错误信息,积极挑战污名,处理困难的在线互动,向公众介绍新的研究,帮助学习招聘,和写帖子时的预防语言。
    结论:这些共识建议可以帮助痴呆症预防研究人员利用社交媒体用于公众参与的目的,并维护痴呆症研究和更广泛社区特有的规范和价值观。
    我们与研究和社区专家一起创建了社交媒体推荐。建议涵盖痴呆症预防研究的关键伦理考虑因素。领域包括错误信息,污名,信息更新,和首选语言。完整的共识建议被组织成七个社交媒体用例。
    BACKGROUND: Practical social media recommendations are needed to facilitate greater engagement in dementia prevention research. Alongside relevant experts, our aim was to develop a set of consensus recommendations that reflect the values and priorities of prospective participants to guide social media use.
    METHODS: We conducted a three-round, modified Delphi consisting of three online surveys and three conferences calls. The diverse, international Delphi panel comprised 16 experts with lived (n = 10) and professional (n = 6) experiences. Consensus was defined a priori as ≥ 70% agreement.
    RESULTS: Twenty-six items achieved consensus. Two items reached consensus in round 1: ethical considerations of closed social media groups (88%) and of social media users sharing prevention content with connections who are not on social media (79%). Nine items reached consensus in round 2, related to misinformation (79%), stigma (93%), and other key aspects of social media communication. After revisions, 15 items reached consensus in the final round. These items included: identifying when researchers ought to engage, managing closed social media groups, rankings of short form content, prioritizing lay summaries and multimedia resources, and rankings of preferred language. One item about the language of prevention for audiences living with dementia did not reach consensus. Final consensus items formed the new set of recommendations, which we organized into seven social media use cases. These use cases include setting up a social media page or community, handling online misinformation, actively challenging stigma, handling difficult online interactions, introducing new research to the public, help with study recruitment, and the language of prevention when writing posts.
    CONCLUSIONS: These consensus recommendations can help dementia prevention researchers harness social media use for the purposes of public engagement and uphold the norms and values specific to the dementia research and broader communities.
    UNASSIGNED: We created social media recommendations with research and community experts.Recommendations cover key ethical considerations for dementia prevention research.Areas include misinformation, stigma, information updates, and preferred language.Full consensus recommendations are organized into seven social media use cases.
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  • 文章类型: English Abstract
    Aromatase inhibitors have been widely used to improve height in the world and China. However, due to their off-label use and relatively short application time, there is a lack of consistent understanding and expert consensus on the indications, efficacy, and side effects of the drugs at home and abroad. Therefore, the Growth and Development and Gonadal Diseases Committee of Chinese Aging Well Association and the Adolescent Medicine and Health Professional Committee of the Chinese Medical Doctor Association organized 28 domestic experts in growth and development, based on the clinical evidence level classification and recommendation level of the Oxford University Evidence-Based Medicine Center to establish some preliminary recommendations on the efficacy, adverse reactions, precautions, dosage, and course of use of aromatase inhibitors in treating children with short stature and improving their year-end height. Combined with the Delphi method evaluation, 14 recommendations were finally formulated to standardized the clinical application of aromatase inhibitors in improving adolescent height.
    芳香化酶抑制剂在全球和中国都广泛应用于改善身高,但因属于超适应证用药,且应用时间相对较短,故国内外对用药的适应证、疗效、不良反应缺乏一致的认识和专家共识。因此中国老年保健协会生长发育和性腺疾病分会和中国医师协会青春期医学与健康专业委员会组织国内28位生长发育方面专家,以牛津大学循证医学中心临床证据水平分级和推荐级别为参照,围绕芳香化酶抑制剂治疗儿童矮身材、改善成年终身高的疗效、不良反应、注意事项、使用剂量和用药疗程等问题,筛选出初步推荐意见。再结合德尔菲法评价意见最终确定14条推荐意见,以规范芳香化酶抑制剂改善青少年身高的临床应用。.
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