■细胞外腺苷(eAdo)连接肿瘤代谢和免疫调节。CD39-CD73-eAdo/A2aR轴调节肿瘤微环境(TME)和免疫治疗反应。在免疫疗法时代,探讨CD39-CD73-eAdo/A2aR轴对TME的影响以及开发靶向治疗药物以增强免疫治疗的疗效是当前的研究热点。本研究总结和探讨了腺苷轴在TME领域的研究趋势和热点,为进一步深入研究提供思路。
■文献信息是从WebofScience核心集合数据库获得的。VOS查看器和基于R的文献计量工具被用来量化和识别合作信息和个人的影响,通过分析全球年度出版物量的详细信息,国家/地区和机构分布,文章作者和共同引用作者,以及这些文章的期刊分布。同时,作者关键词的分布和作者关键词的共现,被高度引用的文章,分析了CD39-CD73-eAdo/A2aR在TME领域的高引用参考文献,以确定研究热点和趋势。
■本研究包括过去十年发表的1,721篇文章。通过文献计量分析,我们发现(1)69个国家和地区探讨了CD39-CD73-eAdo/A2aR对TME的影响,研究总体上呈上升趋势。美国的研究人员主导了这一领域的研究,总引用率最高。中国的出版物数量最多。(2)哈佛大学在这一领域发表的文章最多。(3)12,065位作者为该领域的论文发表做出了贡献,其中23篇发表了至少8篇论文。STAGGJ具有重要的学术影响力,发表了24篇文章,引用了2,776篇。共同引用的作者可以分为三类。StaggJ,AllardB,OhtaA,还有Antonioli,L在网络中占据中心位置。(4)579种学术期刊发表了该领域的文章。《免疫学前沿》杂志发表了最多的论文,有97篇文章,总共引用了2317次,出版物数量逐年增加。(5)“外核苷酸酶CD39和CD73:新型检查点抑制剂靶标”是当地引用次数最多的文章(163次)。“A2A腺苷受体保护肿瘤免受抗肿瘤T细胞的侵害”是共同引用最多的参考文献(224次)。(6)通过对作者关键词的分析,我们发现腺苷与免疫治疗之间的关系是该领域许多研究者的核心概念。乳腺癌,黑色素瘤,结直肠癌,卵巢癌,胶质母细胞瘤,胰腺癌,肝细胞癌,肺癌是腺苷相关肿瘤研究中最常见的癌症类型.免疫疗法,免疫抑制,免疫检查点,免疫检查点抑制剂是研究的热门关键词,反映了腺苷代谢途径在肿瘤免疫治疗中的重要性。关键词如免疫原性细胞死亡,T细胞,Sting,调节性T细胞,先天免疫,和免疫浸润证明了腺苷影响TME的途径。近年来著名的作者关键词一直是免疫治疗,免疫原性细胞死亡,炎症,肺癌,还有胃癌.
■CD39-CD73-eAdo/A2aR对TME中各种免疫细胞的浸润和功能的影响,肿瘤免疫治疗反应,和患者的预后已经引起了许多国家/地区研究人员的关注。美国学者仍然主导着这一领域的研究,但中国学者产生的研究成果最多。《免疫学前沿》杂志发表了该领域最富有的研究。StaggJ是该领域极具影响力的研究人员。进一步探索靶向抑制CD39-CD73-eAdo/A2aR单独或联合其他免疫治疗,放射治疗,和化疗治疗各种癌症和开发有效的临床治疗药物是该领域持续的研究热点。
UNASSIGNED: Extracellular adenosine (eAdo) bridges tumor metabolism and immune regulation. CD39-
CD73-eAdo/A2aR axis regulates tumor microenvironment (TME) and immunotherapy response. In the era of immunotherapy, exploring the impact of the CD39-
CD73-eAdo/A2aR axis on TME and developing targeted therapeutic drugs to enhance the efficacy of immunotherapy are the current research hotspots. This study summarizes and explores the research trends and hotspots of the adenosine axis in the field of TME to provide ideas for further in-depth research.
UNASSIGNED: Literature information was obtained from the Web of Science core collection database. The VOS viewer and the bibliometric tool based on R were used to quantify and identify cooperation information and individual influence by analyzing the detailed information of the global annual publication volume, country/region and institution distribution, article authors and co-cited authors, and journal distribution of these articles. At the same time, the distribution of author keywords and the co-occurrence of author keywords, highly cited articles, and highly co-cited references of CD39-
CD73-eAdo/A2aR in the field of TME were analyzed to determine research hotspots and trends.
UNASSIGNED: 1,721 articles published in the past ten years were included in this study. Through bibliometric analysis, we found that (1) 69 countries and regions explored the effect of the CD39-CD73-eAdo/A2aR on TME, and the research was generally on the rise. Researchers in the United States dominated research in this area, with the highest total citation rate. China had the most significant number of publications. (2) Harvard University has published the most articles in this field. (3) 12,065 authors contributed to the publication of papers in this field, of which 23 published at least eight papers. STAGG J had significant academic influence, with 24 published articles and 2,776 citations. Co-cited authors can be clustered into three categories. Stagg J, Allard B, Ohta A, and Antonioli, L occupied a central position in the network. (4) 579 scholarly journals have published articles in this field. The journal FRONTIERS IN IMMUNOLOGY published the most significant number of papers, with 97 articles and a total of 2,317 citations, and the number of publications increased year by year. (5) \"The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets\" was the most frequently local cited article (163 times). The \"A2A adenosine receptor protects tumors from antitumor T cells\" was the most co-cited reference (224 times). (6) Through the analysis of author keywords, we found that the relationship between adenosine and immunotherapy was a core concept for many researchers in this field. Breast cancer, melanoma, colorectal cancer, ovarian cancer, glioblastoma, pancreatic cancer, hepatocellular carcinoma, and lung cancer were the most frequent cancer types in adenosine-related tumor studies. Immunotherapy, immunosuppression, immune checkpoint, and immune checkpoint inhibitors were the hot keywords in the research, reflecting the importance of the adenosine metabolic pathway in tumor immunotherapy. The keywords such as Immunogenic cell death, T cells, Sting, regulatory T cells, innate immunity, and immune infiltration demonstrated the pathways by which adenosine affected the TME. The famous author keywords in recent years have been immunotherapy, immunogenic cell death, inflammation, lung cancer, and gastric cancer.
UNASSIGNED: The effect of CD39-
CD73-eAdo/A2aR on the infiltration and function of various immune cells in TME, tumor immunotherapy response, and patient prognosis has attracted the attention of researchers from many countries/regions. American scholars still dominate the research in this field, but Chinese scholars produce the most research results. The journal FRONTIERS IN IMMUNOLOGY has published the wealthiest research in the field. Stagg J was a highly influential researcher in this field. Further exploration of targeted inhibition of CD39-
CD73-eAdo/A2aR alone or in combination with other immunotherapy, radiotherapy, and chemotherapy in treating various cancer types and developing effective clinical therapeutic drugs are continuous research hotspots in this field.