PDF(Pubmed)
Abstract：
CD73, a cell surface-bound nucleotidase, serves as a crucial metabolic and immune checkpoint. Several studies have shown that CD73 is widely expressed on immune cells and plays a critical role in immune escape, cell adhesion and migration as a costimulatory molecule for T cells and a factor in adenosine production. However, recent studies have revealed that the protumour effects of CD73 are not limited to merely inhibiting the antitumour immune response. Nicotinamide adenine dinucleotide (NAD+) is a vital bioactive molecule in organisms that plays essential regulatory roles in diverse biological processes within tumours. Accumulating evidence has demonstrated that CD73 is involved in the transport and metabolism of NAD, thereby regulating tumour biological processes to promote growth and proliferation. This review provides a holistic view of CD73-regulated NAD + metabolism as a complex network and further highlights the emerging roles of CD73 as a novel target for cancer therapies.
摘要：
CD73，一种细胞表面结合的核苷酸酶，作为一个关键的代谢和免疫检查点。多项研究表明，CD73在免疫细胞上广泛表达，在免疫逃逸中起着至关重要的作用。细胞粘附和迁移是T细胞的共刺激分子和腺苷产生的因子。然而,最近的研究表明，CD73的质子作用不仅限于抑制抗肿瘤免疫反应。烟酰胺腺嘌呤二核苷酸（NAD）是生物体中重要的生物活性分子，在肿瘤的各种生物过程中起着重要的调节作用。越来越多的证据表明，CD73参与NAD的转运和代谢，从而调节肿瘤生物过程以促进生长和增殖。这篇综述提供了CD73调控的NAD+代谢作为一个复杂的网络的整体观点，并进一步强调了CD73作为癌症治疗新靶点的新兴作用。
