未经证实:由于血管和非血管危险因素,80岁(晚年)后的痴呆症越来越普遍。识别晚期痴呆症风险较高的个体仍然是全球优先事项。
UNASISIGNED:在958名流动社区居住的老年妇女(≥70岁)的前瞻性研究中,1998年从骨密度仪(基线)获取的脊柱侧位图像(LSI)用于评估腹主动脉钙化(AAC).AAC被分为既定类别(低,适度和广泛)。评估心血管危险因素和载脂蛋白E(APOE)基因分型。从相关的医院和死亡率记录中发现了14.5年晚期痴呆症。
未经评估:基线时,女性为75.0±2.6岁,44.7%的AAC较低,36.4%有中度AAC,18.9%有广泛的AAC。超过14.5年,150名(15.7%)女性晚期痴呆症住院(n=132)和/或死亡(n=58)。与低AAC相比,患有中度和广泛性AAC的女性更有可能患晚期痴呆症住院(9.3%,15.5%,18.3%,分别)和死亡(2.8%,8.3%,9.4%,分别)。在调整心血管危险因素和APOE后,患有中度和广泛性AAC的女性患晚期痴呆的相对危害是其两倍(中度,aHR2.0395CI1.38-2.97;广泛,aHR2.1095CI1.33-3.32),与低AAC的女性相比。
未经授权:在社区居住的老年妇女中,那些AAC更晚期的人患晚期痴呆症的风险更高,独立于心血管危险因素和APOE基因型。鉴于骨密度测试的广泛使用,同时捕获AAC信息可能是一种新颖的,非侵入性,可扩展的方法来识别有晚年痴呆风险的老年女性。
未经批准:澳大利亚肾脏健康,西澳大利亚州健康促进基金会,查尔斯·盖尔德纳爵士医院研究咨询委员会格兰特,澳大利亚国家卫生和医学研究委员会。
UNASSIGNED: Dementia after the age of 80 years (late-life) is increasingly common due to vascular and non-vascular risk factors. Identifying individuals at higher risk of late-life dementia remains a global priority.
UNASSIGNED: In prospective study of 958 ambulant community-dwelling older women (≥70 years), lateral spine images (LSI) captured in 1998 (baseline) from a bone density machine were used to assess abdominal aortic calcification (AAC). AAC was classified into established categories (low, moderate and extensive). Cardiovascular risk factors and apolipoprotein E (APOE) genotyping were evaluated. Incident 14.5-year late-life dementia was identified from linked hospital and mortality records.
UNASSIGNED: At baseline women were 75.0 ± 2.6 years, 44.7% had low AAC, 36.4% had moderate AAC and 18.9% had extensive AAC. Over 14.5- years, 150 (15.7%) women had a late-life dementia hospitalisation (n = 132) and/or death (n = 58). Compared to those with low AAC, women with moderate and extensive AAC were more likely to suffer late-life dementia hospitalisations (9.3%, 15.5%, 18.3%, respectively) and deaths (2.8%, 8.3%, 9.4%, respectively). After adjustment for cardiovascular risk factors and APOE, women with moderate and extensive AAC had twice the relative hazards of late-life dementia (moderate, aHR 2.03 95%CI 1.38-2.97; extensive, aHR 2.10 95%CI 1.33-3.32), compared to women with low AAC.
UNASSIGNED: In community-dwelling older women, those with more advanced AAC had higher risk of late-life dementia, independent of cardiovascular risk factors and APOE genotype. Given the widespread use of bone density testing, simultaneously capturing AAC information may be a novel, non-invasive, scalable approach to identify older women at risk of late-life dementia.
UNASSIGNED: Kidney Health Australia, Healthway Health Promotion Foundation of Western Australia, Sir Charles Gairdner Hospital Research Advisory Committee Grant, National Health and Medical Research Council of Australia.