PDF(Pubmed)
Abstract：
UNASSIGNED: To clarify the role of mediators of ectopic mineralization as biomarkers for arterial calcifications.
UNASSIGNED: MEDLINE and Embase were searched for relevant literature, until January 4th 2022. The investigated biomarkers were: calcium, phosphate, parathyroid hormone, vitamin D, pyrophosphate, osteoprotegerin, receptor activator of nuclear factor-kappa B ligand (RANKL), fibroblast growth factor-23 (FGF-23), Klotho, osteopontin, osteocalcin, Matrix Gla protein (MGP) and its inactive forms and vitamin K. Studies solely performed in patients with kidney insufficiency or diabetes mellitus were excluded.
UNASSIGNED: After screening of 8985 articles, a total of 129 articles were included in this systematic review. For all biomarkers included in this review, the results were variable and more than half of the studies for each specific biomarker had a non-significant result. Also, the overall quality of the included studies was low, partly as a result of the mostly cross-sectional study designs. The largest body of evidence is available for phosphate, osteopontin and FGF-23, as a little over half of the studies showed a significant, positive association. Firm statements for these biomarkers cannot be drawn, as the number of studies was limited and hampered by residual confounding or had non-significant results. The associations of the other mediators of ectopic mineralization with arterial calcifications were not clear.
UNASSIGNED: Associations between biomarkers of ectopic mineralization and arterial calcification are variable in the published literature. Future longitudinal studies differentiating medial and intimal calcification could add to the knowledge of biomarkers and mechanisms of arterial calcifications.
UNASSIGNED: MEDLINE and Embase were searched for relevant literature, until January 4th 2022. The investigated biomarkers were: calcium, phosphate, parathyroid hormone, vitamin D, pyrophosphate, osteoprotegerin, receptor activator of nuclear factor-kappa B ligand (RANKL), fibroblast growth factor-23 (FGF-23), Klotho, osteopontin, osteocalcin, Matrix Gla protein (MGP) and its inactive forms and vitamin K. Studies solely performed in patients with kidney insufficiency or diabetes mellitus were excluded.
UNASSIGNED: After screening of 8985 articles, a total of 129 articles were included in this systematic review. For all biomarkers included in this review, the results were variable and more than half of the studies for each specific biomarker had a non-significant result. Also, the overall quality of the included studies was low, partly as a result of the mostly cross-sectional study designs. The largest body of evidence is available for phosphate, osteopontin and FGF-23, as a little over half of the studies showed a significant, positive association. Firm statements for these biomarkers cannot be drawn, as the number of studies was limited and hampered by residual confounding or had non-significant results. The associations of the other mediators of ectopic mineralization with arterial calcifications were not clear.
UNASSIGNED: Associations between biomarkers of ectopic mineralization and arterial calcification are variable in the published literature. Future longitudinal studies differentiating medial and intimal calcification could add to the knowledge of biomarkers and mechanisms of arterial calcifications.
摘要：
■阐明异位矿化介质作为动脉钙化生物标志物的作用。
■搜索MEDLINE和Embase的相关文献，直到2022年1月4日。研究的生物标志物是：钙，磷酸盐,甲状旁腺激素,维生素D,焦磷酸盐,骨保护素,核因子-κB受体活化因子配体（RANKL），成纤维细胞生长因子-23(FGF-23),Klotho,骨桥蛋白,骨钙蛋白，基质Gla蛋白（MGP）及其非活性形式和维生素K。排除仅在肾功能不全或糖尿病患者中进行的研究。
■在筛选了8985篇文章后，本系统综述共纳入129篇文章.对于本综述中包含的所有生物标志物，结果是可变的,超过一半的研究中每种特定生物标志物的结果均不显著.此外，纳入研究的总体质量较低，部分原因是主要是横断面研究设计。最大的证据是磷酸盐，骨桥蛋白和FGF-23，一半以上的研究表明，正关联。无法得出这些生物标志物的确切陈述，由于研究数量有限,并受到残留混杂因素的阻碍,或者结果不显著.其他异位矿化介质与动脉钙化的关联尚不清楚。
■异位矿化和动脉钙化的生物标志物之间的关联在已发表的文献中是可变的。未来区分内侧和内膜钙化的纵向研究可以增加对生物标志物和动脉钙化机制的认识。
■搜索MEDLINE和Embase的相关文献，直到2022年1月4日。研究的生物标志物是：钙，磷酸盐,甲状旁腺激素,维生素D,焦磷酸盐,骨保护素,核因子-κB受体活化因子配体（RANKL），成纤维细胞生长因子-23(FGF-23),Klotho,骨桥蛋白,骨钙蛋白，基质Gla蛋白（MGP）及其非活性形式和维生素K。排除仅在肾功能不全或糖尿病患者中进行的研究。
■在筛选了8985篇文章后，本系统综述共纳入129篇文章.对于本综述中包含的所有生物标志物，结果是可变的,超过一半的研究中每种特定生物标志物的结果均不显著.此外，纳入研究的总体质量较低，部分原因是主要是横断面研究设计。最大的证据是磷酸盐，骨桥蛋白和FGF-23，一半以上的研究表明，正关联。无法得出这些生物标志物的确切陈述，由于研究数量有限,并受到残留混杂因素的阻碍,或者结果不显著.其他异位矿化介质与动脉钙化的关联尚不清楚。
■异位矿化和动脉钙化的生物标志物之间的关联在已发表的文献中是可变的。未来区分内侧和内膜钙化的纵向研究可以增加对生物标志物和动脉钙化机制的认识。
