背景:在过去的几十年中,人们普遍认为,影响免疫系统及其不同途径的因素会导致炎症和炎症的病理进展。慢性炎症也有助于常见疾病,比如糖尿病,缺血性心脏病,癌症,慢性肾炎性疾病,非酒精性脂肪性肝病,自身免疫性疾病和神经退行性疾病。
目标:有趣的是,几个世纪以来,植物来源和植物的次生代谢物越来越多地用于治疗急性和慢性炎症性疾病。乳香酸是从不同乳香物种的油树胶树脂获得的五环三萜部分。
方法:通过各种数据库收集了详细的数据,揭示了Boswellic酸的抗炎潜力。
结果:这些药物具有良好的抗炎活性,抗关节炎,抗风湿,抗腹泻,抗高脂血症,抗哮喘,抗癌,和抗微生物作用。
结论:自古以来,Boswellic酸主要用于治疗急性和慢性炎性疾病。这篇综述讨论了炎症过程的各种机制以及这些天然产物作为治疗炎症性疾病的药物的必要性。此外,我们还讨论了与炎症相关的主要靶点.该综述通过分析大量报道的科学研究,进一步探讨了乳香酸在慢性炎症性疾病中的治疗潜力。
BACKGROUND: In the last few decades, it has been largely perceived that the factors affecting the immune system and its varying pathways lead to the pathological progression of inflammation and inflammatory conditions. Chronic inflammation also contributes to common diseases, such as diabetes mellitus, ischemic heart disease, cancer, chronic renal inflammatory disease, non-alcoholic fatty hepat-ic disease, autoimmune diseases and neurodegenerative diseases.
OBJECTIVE: Interestingly, plant sources and secondary metabolites from plants have been increasingly employed in managing acute and chronic inflammatory diseases for centuries. Boswellic acids are pentacyclic triterpenoidal moieties obtained from the oleo gum resin of different Boswellia species.
METHODS: Detailed data was collected revealing the anti-inflammatory potential of Boswellic acids through various databases.
RESULTS: These are pharmacologically active agents that possess promising anti-inflammatory, anti-arthritic, antirheumatic, anti-diarrheal, anti-hyperlipidemic, anti-asthmatic, anti-cancer, and anti-microbial effects.
CONCLUSIONS: Boswellic acids have been in use since ancient times primarily to treat acute and chronic inflammatory diseases. This review discusses the various mechanisms underlying the inflammatory process and the necessity of such natural products as a medication to treat inflammatory diseases. In addition, a discussion has also been extended to understand the primary targets involved in inflammation. The review further explores the therapeutic potential of boswellic acids in.