Abstract：
UNASSIGNED: Boswellic acids (BAs) are a group of pentacyclic triterpenoids of the ursane and oleanane type. They have shown very interesting biological properties that have led to the development of a number of synthesis protocols. Both natural BAs and their synthetic derivatives may be useful in the treatment of a variety of cancers, viral infections and inflammatory diseases.
UNASSIGNED: This review covers patents relating to the therapeutic activities of natural BAs and their synthetic derivatives. The latest patented studies of boswellic acids (are summarized by using the keywords \'boswellic acid,\' in SciFinder, PubMed, and Google Patents and databases in the year from 2016 to 2023.
UNASSIGNED: Boswellic acids have shown potent antiviral, anticancer and anti-inflammatory potential. Few BAs analogues have been prepared by modification at the C24-CO2H functional groups. In particular, the C-24 amide and amino analogues have shown enhanced anticancer effects compared to the parent AKBA. In addition, BAs have the ability to form conjugates with other antiviral, anti-inflammatory and anticancer drugs that synergistically enhance their biological efficacy. In addition, this conjugation strategy will increase the solubility and bioavailability of BAs, which is one of the most important issues in the development of BAs.
UNASSIGNED: This review covers patents relating to the therapeutic activities of natural BAs and their synthetic derivatives. The latest patented studies of boswellic acids (are summarized by using the keywords \'boswellic acid,\' in SciFinder, PubMed, and Google Patents and databases in the year from 2016 to 2023.
UNASSIGNED: Boswellic acids have shown potent antiviral, anticancer and anti-inflammatory potential. Few BAs analogues have been prepared by modification at the C24-CO2H functional groups. In particular, the C-24 amide and amino analogues have shown enhanced anticancer effects compared to the parent AKBA. In addition, BAs have the ability to form conjugates with other antiviral, anti-inflammatory and anticancer drugs that synergistically enhance their biological efficacy. In addition, this conjugation strategy will increase the solubility and bioavailability of BAs, which is one of the most important issues in the development of BAs.
摘要：
■Boswellic酸（BA）是一组ursane和iianane类型的五环三萜类。它们已经显示出非常有趣的生物学特性，这导致了许多合成方案的发展。天然BA及其合成衍生物可用于治疗多种癌症。病毒感染和炎性疾病。
■本综述涵盖了与天然BA及其合成衍生物的治疗活性有关的专利。乳香酸的最新专利研究（通过使用关键词\'乳香酸，\'在SciFinder中,PubMed,以及2016年至2023年的Google专利和数据库。
■乳香酸已显示出有效的抗病毒作用，抗癌和抗炎潜力。通过在C24-CO2H官能团处的修饰已经制备了很少的BA类似物。特别是,与母体AKBA相比,C-24酰胺和氨基类似物显示出增强的抗癌作用。此外,BA具有与其他抗病毒药物形成缀合物的能力，抗炎和抗癌药物，协同增强其生物功效。此外,这种结合策略将增加BAs的溶解度和生物利用度，这是BAs发展中最重要的问题之一。
■本综述涵盖了与天然BA及其合成衍生物的治疗活性有关的专利。乳香酸的最新专利研究（通过使用关键词\'乳香酸，\'在SciFinder中,PubMed,以及2016年至2023年的Google专利和数据库。
■乳香酸已显示出有效的抗病毒作用，抗癌和抗炎潜力。通过在C24-CO2H官能团处的修饰已经制备了很少的BA类似物。特别是,与母体AKBA相比,C-24酰胺和氨基类似物显示出增强的抗癌作用。此外,BA具有与其他抗病毒药物形成缀合物的能力，抗炎和抗癌药物，协同增强其生物功效。此外,这种结合策略将增加BAs的溶解度和生物利用度，这是BAs发展中最重要的问题之一。
