目的:本研究旨在系统地比较使用牛来源的异种移植物和各种合成骨移植材料进行侧向MSFA治疗的患者。
方法:发布,Scopus,Embase,和Cochrane图书馆在2023年4月之前进行了搜索,并在选定的期刊中进行了手动搜索。报告组织学结果的研究(残余植骨,新形成的骨头,非矿化组织)和临床结果(植入物存活率,ISQ值)包括在内。进行了几项分析,包括荟萃分析,敏感性研究,和Egger的回归测试。
结果:本系统综述包括16项临床/随机对照试验,其中12人纳入荟萃分析.通过混合HA/TCP在移植窦内新形成的骨的百分比显着高于异种移植物(WMD2.85,95CI[0.72;4.99]),但纯HA(WMD-1.72,95CI[-3.15;-0.29])或TCP(WMD-7.10,95CI[-13.02;-1.17])嫁接的细胞明显低于异种移植物。合成HA产生的残余骨移植物和非矿化组织,TCP,HA/TCP与异种移植组无显着差异。
结论:外侧MSFA中移植骨替代物的化学性质影响了新形成的骨的数量。与牛来源的HA相比,那些用杂合HA/TCP移植的骨产生的新骨量最高。然而,这种影响对残余骨移植物和非矿化组织不显著.
OBJECTIVE: This study aimed to systematically compare the patients undergoing lateral MSFA therapies utilizing bovine-originated xenografts versus varied synthetic bone grafting materials.
METHODS: Pubmed, Scopus, Embase, and Cochrane Library were searched up to April 2023, compensated by a manual search in selected journals. Studies reporting histological outcomes (residual bone graft, newly formed bone, non-mineralized tissue) and clinical outcomes (implant survival, ISQ value) were included. Several analyses were performed, including meta-analysis, sensitivity study, and Egger\'s regression tests.
RESULTS: Sixteen clinical/randomized control trials were included in this systematic review, among which 12 were enrolled in a meta-analysis. The percentage of newly formed bone within the grafted sinuses by hybrid HA/TCP was significantly higher than those by xenografts (WMD 2.85, 95%CI [0.72; 4.99]), but those grafted by pure HA (WMD -1.72, 95%CI [-3.15; -0.29]) or TCP (WMD -7.10, 95%CI [-13.02; -1.17]) were significantly lower than xenograft counterparts. The residual bone graft and non-mineralized tissue yielded by synthetic HA, TCP, and HA/TCP showed no significant differences with the xenograft group.
CONCLUSIONS: The chemistry of grafted bone substitutes in lateral MSFA influenced the quantity of newly formed bone. Those grafted with hybrid HA/TCP yielded the highest amount of new bone compared to bovine-originated HA. However, this influence was not significant on residual bone graft and non-mineralized tissue.