PDF(Pubmed)
Abstract：
Periodontitis is a serious form of oral gum inflammation with recession of gingival soft tissue, destruction of the periodontal ligament, and absorption of alveolar bone. Management of periodontal tissue and bone destruction, along with the restoration of functionality and structural integrity, is not possible with conventional clinical therapy alone. Guided bone and tissue regeneration therapy employs an occlusive biodegradable barrier membrane and graft biomaterials to guide the formation of alveolar bone and tissues for periodontal restoration and regeneration. Amongst several grafting approaches, alloplastic grafts/biomaterials, either derived from natural sources, synthesization, or a combination of both, offer a wide variety of resources tailored to multiple needs. Examining several pertinent scientific databases (Web of Science, Scopus, PubMed, MEDLINE, and Cochrane Library) provided the foundation to cover the literature on synthetic graft materials and membranes, devoted to achieving periodontal tissue and bone regeneration. This discussion proceeds by highlighting potential grafting and barrier biomaterials, their characteristics, efficiency, regenerative ability, therapy outcomes, and advancements in periodontal guided regeneration therapy. Marketed and standardized quality products made of grafts and membrane biomaterials have been documented in this work. Conclusively, this paper illustrates the challenges, risk factors, and combination of biomaterials and drug delivery systems with which to reconstruct the hierarchical periodontium.
摘要：
牙周炎是一种严重的口腔牙龈炎症，牙龈软组织萎缩，牙周膜的破坏，和牙槽骨的吸收。牙周组织和骨破坏的管理，随着功能和结构完整性的恢复，单独使用常规临床治疗是不可能的。引导骨和组织再生疗法采用闭塞性生物可降解屏障膜和移植生物材料来引导牙槽骨和组织的形成，以进行牙周修复和再生。在几种嫁接方法中，异体移植物/生物材料，要么来自自然来源，合成，或者两者的结合，提供适合多种需求的各种资源。检查几个相关的科学数据库(WebofScience，Scopus,PubMed,MEDLINE,和Cochrane图书馆）提供了涵盖合成移植材料和膜文献的基础，致力于实现牙周组织和骨再生。通过强调潜在的嫁接和屏障生物材料，他们的特点,效率,再生能力,治疗结果，以及牙周引导再生治疗的进展。这项工作已记录了由移植物和膜生物材料制成的市场和标准化优质产品。最后，本文阐述了挑战，危险因素，以及生物材料和药物递送系统的组合，用于重建分级牙周组织。
