■研究的目的是确定与2型糖尿病(T2D)相关的七组中的每个成员在载脂蛋白E基因型(2/2、2/3、2/4、3/3、3/4和4/4)之间是否存在统计学上的显着差异或趋势。七组包括腹部肥胖,高血压,血小板高聚集性,高血糖症,血脂异常(高密度脂蛋白胆固醇(HDL-C)的血浆水平降低和甘油三酯的血浆水平升高),低密度脂蛋白(LDL)氧化增加,增加炎症。
■46名T2D控制良好的患者参加了这项研究。腹型肥胖(通过腰围评估),高血压(通过手动血压计测量),血小板高聚集性(通过出血时间测量),高血糖症(通过酶试剂盒和分光光度法),HDL-C的血浆水平降低和甘油三酯的血浆水平升高(通过酶试剂盒和分光光度法),确定了LDL氧化增加(使用分光光度法通过LDL共轭二烯测量)和C反应蛋白(CRP)(通过EIA试剂盒)测量的炎症增加。
■所有基因型,除了2/2在研究人群中发现。腹部肥胖在五种基因型之间没有显着差异。然而,葡萄糖水平从2/3到2/4到3/4到4/4逐渐升高。收缩压在3/4高于2/4,在3/4高于3/3。舒张压在3/3比2/4中趋于升高,在3/4中明显高于2/4。甘油三酯在3/4比3/3中倾向于更高,而HDL-C在4/4与2/4相比接近下降趋势。出血时间不受基因型影响。血浆LDL共轭二烯在3/4比2/4中趋于更高,在3/4比3/3中明显更高。CRP在4/4比2/3中呈上升趋势。
■我们可以得出结论,在存在另一个等位基因为2、3或4的情况下,具有至少一个4等位基因的那些可能(在趋势的情况下)有害或在高血糖方面有害。高血压(收缩压和舒张压),血脂异常,LDL共轭二烯和CRP水平。
UNASSIGNED: The objective of the study was to determine if there would be statistically significant differences or trends among apolipoprotein E genotypes (2/2, 2/3, 2/4, 3/3, 3/4, and 4/4) for each member of the cluster of seven associated with type 2 diabetes (T2D). The cluster of seven includes abdominal obesity, hypertension, platelet hyperaggregability, hyperglycemia, dyslipidemia (decreased plasma levels of high-density lipoprotein cholesterol (HDL-C) and increased plasma levels of triglycerides)), increased low-density lipoprotein (LDL) oxidation, and increased inflammation.
UNASSIGNED: Forty-six patients with well-controlled T2D participated in the study. Abdominal obesity (assessed by waist circumference), hypertension (measured by manual sphygmomanometry), platelet hyperaggregability (measured by bleeding time), hyperglycemia (by enzymatic kit and spectrophotometry), decreased plasma levels of HDL-C and increased plasma levels of triglycerides (by enzymatic kit and spectrophotometry), increased LDL oxidation (measured by LDL conjugated dienes using spectrophotometry) and increased inflammation measured by C-reactive protein (CRP) (by EIA kit) were determined.
UNASSIGNED: All genotypes, except 2/2 were found in the population studied. Abdominal obesity did not vary significantly across the five genotypes. However, glucose levels trended progressively higher going from 2/3 to 2/4 to 3/4 to 4/4. Systolic blood pressure was higher in 3/4 compared to 2/4 and trended higher in 3/4 compared to 3/3. Diastolic blood pressure trended higher in 3/3 vs 2/4 and significantly higher in 3/4 compared to 2/4. Triglycerides trended higher in 3/4 vs 3/3 while HDL-C came close to trending downward in 4/4 compared to 2/4. Bleeding time was unaffected by genotype. Plasma LDL conjugated dienes trended higher in 3/4 vs 2/4 and were significantly higher in 3/4 vs 3/3. CRP trended higher in 4/4 vs 2/3.
UNASSIGNED: We can conclude that those with at least one 4 allele in the presence of another allele being 2, 3 or 4 is potentially (in the case of trends) deleterious or is deleterious in terms of hyperglycemia, hypertension (systolic and diastolic blood pressure), dyslipidemia, LDL conjugated dienes and CRP levels.