Abstract：
OBJECTIVE: Despite the importance of self-monitoring blood glucose (SMBG) for management of diabetes mellitus (DM), frequent blood sampling is discouraged by bleeding risk due to dual-antiplatelet agent therapy (DAPT) or thrombocytopenia.
METHODS: We compared the bleeding time (BT) of sampling by using a laser-lancing-device (LMT-1000) and a conventional lancet in patients with DM and thrombocytopenia or patients undergoing DAPT. BT was measured using the Duke method, and pain and satisfaction scores were assessed using numeric rating scale (NRS) and visual analog scale (VAS). The consistency in the values of glucose and glycated-hemoglobin (HbA1c) sampled using the LMT-1000 or lancet were compared.
RESULTS: The BT of sampling with the LMT-1000 was shorter than that with the lancet in patients with thrombocytopenia (60s vs. 85s, P = 0.024). The NRS was lower and the VAS was higher in laser-applied-sampling than lancet-applied sampling in the DAPT-user group (NRS: 1 vs. 2, P = 0.010; VAS: 7 vs. 6, P = 0.003), whereas the group with thrombocytopenia only showed improvement in the VAS score (8 vs. 7, P = 0.049). Glucose and HbA1c sampled by the LMT-1000 and lancet were significantly correlated in both the DAPT-user and the thrombocytopenia groups.
CONCLUSIONS: The LMT-1000 can promote SMBG by shortening BT in subject with thrombocytopenia and by increasing satisfaction score, as well as by showing reliable glucose and HbA1c value.
METHODS: We compared the bleeding time (BT) of sampling by using a laser-lancing-device (LMT-1000) and a conventional lancet in patients with DM and thrombocytopenia or patients undergoing DAPT. BT was measured using the Duke method, and pain and satisfaction scores were assessed using numeric rating scale (NRS) and visual analog scale (VAS). The consistency in the values of glucose and glycated-hemoglobin (HbA1c) sampled using the LMT-1000 or lancet were compared.
RESULTS: The BT of sampling with the LMT-1000 was shorter than that with the lancet in patients with thrombocytopenia (60s vs. 85s, P = 0.024). The NRS was lower and the VAS was higher in laser-applied-sampling than lancet-applied sampling in the DAPT-user group (NRS: 1 vs. 2, P = 0.010; VAS: 7 vs. 6, P = 0.003), whereas the group with thrombocytopenia only showed improvement in the VAS score (8 vs. 7, P = 0.049). Glucose and HbA1c sampled by the LMT-1000 and lancet were significantly correlated in both the DAPT-user and the thrombocytopenia groups.
CONCLUSIONS: The LMT-1000 can promote SMBG by shortening BT in subject with thrombocytopenia and by increasing satisfaction score, as well as by showing reliable glucose and HbA1c value.
摘要：
目的：尽管自我监测血糖（SMBG）对于糖尿病（DM）的管理很重要，由于双联抗血小板药物治疗(DAPT)或血小板减少症导致的出血风险,不鼓励频繁采血.
方法：我们比较了DM和血小板减少症患者或DAPT患者使用激光穿刺装置（LMT-1000）和常规刺血针采样的出血时间（BT）。BT是用杜克法测量的，使用数字评定量表（NRS）和视觉模拟量表（VAS）评估疼痛和满意度评分。比较了使用LMT-1000或刺血针采样的葡萄糖和糖化血红蛋白（HbA1c）值的一致性。
结果：在血小板减少症患者中，使用LMT-1000采样的BT短于使用柳叶刀采样的BT（60svs.85s,P=0.024)。在DAPT用户组中，激光应用采样的NRS较低，VAS较高（NRS：1vs.2，P=0.010；VAS：7vs.6,P=0.003),而血小板减少组仅显示VAS评分改善(8vs.7,P=0.049)。LMT-1000和刺血针采样的葡萄糖和HbA1c在DAPT使用者和血小板减少症组中均显着相关。
结论：LMT-1000可以通过缩短血小板减少症患者的BT和提高满意度得分来促进SMBG，以及通过显示可靠的葡萄糖和HbA1c值。
方法：我们比较了DM和血小板减少症患者或DAPT患者使用激光穿刺装置（LMT-1000）和常规刺血针采样的出血时间（BT）。BT是用杜克法测量的，使用数字评定量表（NRS）和视觉模拟量表（VAS）评估疼痛和满意度评分。比较了使用LMT-1000或刺血针采样的葡萄糖和糖化血红蛋白（HbA1c）值的一致性。
结果：在血小板减少症患者中，使用LMT-1000采样的BT短于使用柳叶刀采样的BT（60svs.85s,P=0.024)。在DAPT用户组中，激光应用采样的NRS较低，VAS较高（NRS：1vs.2，P=0.010；VAS：7vs.6,P=0.003),而血小板减少组仅显示VAS评分改善(8vs.7,P=0.049)。LMT-1000和刺血针采样的葡萄糖和HbA1c在DAPT使用者和血小板减少症组中均显着相关。
结论：LMT-1000可以通过缩短血小板减少症患者的BT和提高满意度得分来促进SMBG，以及通过显示可靠的葡萄糖和HbA1c值。
