在临床实践中增加使用牙科植入物的主要原因与美学参数有关。植入物也是保存和刺激天然骨骼的唯一技术。然而,有几个与感染相关的问题,如种植体周围炎。这种疾病揭示了进行性炎症作用,影响植入物周围的硬组织和软组织,导致植入物丢失。为了防止这种疾病的发作,已经建议用生物活性玻璃涂覆植入物。除了其促进骨再生的内在功能外,也可以插入治疗离子,如铈。当目的是改善骨整合并防止牙科植入物放置的感染性问题时,铈具有几个优点。它促进成骨细胞的生长和分化,改善骨骼的机械性能,并防止植入物表面可能发生的细菌粘附和增殖。这种抗菌作用是由于其破坏细菌细胞壁和细胞膜的能力,从而干扰重要的代谢功能,如呼吸。此外,其抗氧化作用逆转骨植入后的氧化应激。在这项工作中,通过熔体淬火法开发了具有不同百分比(0.25、0.5、1和2mol%)的CeO2的生物玻璃45S5。对材料进行了形态学分析,结构,和生物学(细胞毒性,生物活性,和抗菌活性)特性。铈的添加不会促进生物活性玻璃的结构变化,其显示对于所有铈含量高达25mg/mL的提取物浓度的Saos-2细胞系没有细胞毒性。对于最大铈浓度(2mol%),生物活性玻璃对大肠杆菌和变形链球菌细菌具有明显的抑制作用。此外,
The main reason for the increased use of dental implants in clinical practice is associated with aesthetic parameters. Implants are also presented as the only technique that conserves and stimulates natural bone. However, there are several problems associated with infections, such as peri-implantitis. This disease reveals a progressive inflammatory action that affects the hard and soft tissues surrounding the implant, leading to implant loss. To prevent the onset of this disease, coating the implant with bioactive glasses has been suggested. In addition to its intrinsic function of promoting bone regeneration, it is also possible to insert therapeutic ions, such as cerium. Cerium has several advantages when the aim is to improve osseointegration and prevent infectious problems with dental implant placement. It promotes increased growth and the differentiation of osteoblasts, improves the mechanical properties of bone, and prevents bacterial adhesion and proliferation that may occur on the implant surface. This antibacterial effect is due to its ability to disrupt the cell wall and membrane of bacteria, thus interfering with vital metabolic functions such as respiration. In addition, its antioxidant effect reverses oxidative stress after implantation in bone. In this work, Bioglass 45S5 with CeO2 with different percentages (0.25, 0.5, 1, and 2 mol%) was developed by the melt-quenching method. The materials were analyzed in terms of morphological, structural, and biological (cytotoxicity, bioactivity, and antibacterial activity) properties. The addition of cerium did not promote structural changes to the bioactive glass, which shows no cytotoxicity for the Saos-2 cell line up to 25 mg/mL of extract concentration for all cerium contents. For the maximum cerium concentration (2 mol%) the bioactive glass shows an evident inhibitory effect for Escherichia coli and Streptococcus mutans bacteria. Furthermore, all samples showed the beginning of the deposition of a CaP-rich layer on the surface of the material after 24 h.