PDF(Pubmed)
Abstract：
The aging population and increasing incidence of trauma among younger age groups have heightened the increasing demand for reliable implant materials. Effective implant materials must demonstrate rapid osseointegration and strong antibacterial properties to ensure optimal patient outcomes and decrease the chance of implant rejection. This study aims to enhance the bone-implant interface by utilizing 45S5 bioglass modified with various concentrations of Fe3O4 as a coating material. The effect of the insertion of Fe3O4 into the bioglass structure was studied using Raman spectroscopy which shows that with the increase in Fe3O4 concentration, new vibration bands associated with Fe-related structural units appeared within the sample. The bioactivity of the prepared glasses was evaluated using immersion tests in simulated body fluid, revealing the formation of a calcium phosphate-rich layer within 24 h on the samples, indicating their potential for enhanced tissue integration. However, the sample modified with 8 mol% of Fe3O4 showed low reactivity, developing a calcium phosphate-rich layer within 96 h. All the bioglasses showed antibacterial activity against the Gram-positive and Gram-negative bacteria. The modified bioglass did not present significant antibacterial properties compared to the bioglass base.
摘要：
人口老龄化和年轻年龄组中创伤发生率的增加增加了对可靠植入材料的需求。有效的植入材料必须表现出快速的骨整合和强大的抗菌性能，以确保最佳的患者预后并减少植入物排斥的机会。这项研究旨在通过利用用各种浓度的Fe3O4修饰的45S5生物玻璃作为涂层材料来增强骨-植入物界面。使用拉曼光谱研究了将Fe3O4插入到生物玻璃结构中的影响，结果表明，随着Fe3O4浓度的增加，样品中出现了与Fe相关结构单元相关的新振动带。使用在模拟体液中的浸入测试来评估所制备眼镜的生物活性，揭示了在24小时内样品上形成的富含磷酸钙的层，表明它们增强组织整合的潜力。然而,用8摩尔%的Fe3O4改性的样品显示出低反应性，在96小时内形成富含磷酸钙的层。所有生物类菌均显示出对革兰氏阳性和革兰氏阴性细菌的抗菌活性。与生物玻璃基质相比,改性生物玻璃不呈现显著的抗菌性质。
