皮肤病学和美容学目前优先考虑健康,年轻的皮肤。因此,世界各地正在进行研究,以发现允许控制释放的天然物质和载体,这可以帮助对抗各种皮肤疾病并减缓衰老过程。这项研究检查了含有大麻二酚(CBD)和α-松油醇(TER)的新型水凝胶的生物学和物理化学特征。水凝胶由ε-己内酯(CL)和聚(乙二醇)(PEG)共聚物获得,二甘醇(DEG),聚(四氢呋喃)(PTHF),1,6-二异氰酸己烷(HDI),和壳聚糖(CHT)成分,而可生物降解的低聚物是使用酶开环聚合(e-ROP)方法合成的。活性化合物从水凝胶中的体外释放速率主要通过一级动力学表征,没有“突发释放”。抗菌剂,抗炎,细胞毒性,抗氧化剂,并对设计的给药系统(DDS)的抗衰老质量进行了评估。研究结果表明,开发的水凝胶载体具有清除自由基和影响抗氧化酶活性的能力,同时避免了对角质形成细胞和成纤维细胞的任何负面影响。此外,它们通过阻止蛋白质变性以及蛋白酶和脂氧合酶的活性而具有抗炎特性。此外,已证明它们能够减少病原菌的繁殖并抑制胶原酶和弹性蛋白酶的活性。因此,开发的水凝胶载体可能是控制CBD递送的有效系统,这可能成为美容师和皮肤科医生的宝贵工具。
Dermatology and cosmetology currently prioritize healthy, youthful-looking skin. As a result, research is being conducted worldwide to uncover natural substances and carriers that allow for controlled release, which could aid in the battle against a variety of skin illnesses and slow the aging process. This study examined the biological and physicochemical features of novel hydrogels containing cannabidiol (CBD) and α-terpineol (TER). The hydrogels were obtained from ε-caprolactone (CL) and poly(ethylene glycol) (PEG) copolymers, diethylene glycol (DEG), poly(tetrahydrofuran) (PTHF), 1,6-diisocyanatohexane (HDI), and chitosan (CHT) components, whereas the biodegradable oligomers were synthesized using the enzyme ring-opening polymerization (e-ROP) method. The in vitro release rate of the active compounds from the hydrogels was characterized by mainly first-order kinetics, without a \"burst release\". The antimicrobial, anti-inflammatory, cytotoxic, antioxidant, and anti-aging qualities of the designed drug delivery systems (DDSs) were evaluated. The findings indicate that the hydrogel carriers that were developed have the ability to scavenge free radicals and impact the activity of antioxidant enzymes while avoiding any negative effects on keratinocytes and fibroblasts. Furthermore, they have anti-inflammatory qualities by impeding protein denaturation as well as the activity of proteinase and lipoxygenase. Additionally, their ability to reduce the multiplication of pathogenic bacteria and inhibit the activity of collagenase and elastase has been demonstrated. Thus, the developed hydrogel carriers may be effective systems for the controlled delivery of CBD, which may become a valuable tool for cosmetologists and dermatologists.