{Reference Type}: Journal Article {Title}: Developing multifunctional cellulose derivatives for environmental and biomedical applications: Insights into modification processes and advanced material properties. {Author}: Aziz T;Li W;Zhu J;Chen B; {Journal}: Int J Biol Macromol {Volume}: 278 {Issue}: 0 {Year}: 2024 Aug 14 {Factor}: 8.025 {DOI}: 10.1016/j.ijbiomac.2024.134695 {Abstract}: The growing bioeconomic demand for lightweight, eco-friendly materials with functional versatility and competitive mechanical properties drives the resurgence of cellulose as a sustainable scaffold for various applications. This review comprehensively scrutinizes current progressions in cellulose functional materials (CFMs), concentrating on their structure-property connections. Significant modification methods, including cross-linking, grafting, and oxidation, are discussed together with preparation techniques categorized by cellulose sources. This review article highlights the extensive usage of modified cellulose in various industries, particularly its potential in optical and toughening applications, membrane production, and intelligent bio-based systems. Prominence is located on low-cost procedures for developing biodegradable polymers and the physical-chemical characteristics essential for biomedical applications. Furthermore, the review explores the role of cellulose derivatives in smart packaging films for food quality monitoring and deep probes into cellulose's mechanical, thermal, and structural characteristics. The multifunctional features of cellulose derivatives highlight their worth in evolving environmental and biomedical engineering applications.