新型生物材料在治疗人类疾病方面变得越来越重要。然而,许多材料需要复杂的人工修饰和合成,导致准备工作中的潜在困难,副作用,和临床翻译。最近,在草药天然产物(NPHM)的直接自组装方面取得了重大进展,新药物的重要来源,产生了广泛的生物活性超分子材料,包括凝胶,和纳米粒子。基于NPHM的超分子生物活性材料是由可再生资源生产的,很容易准备,并展示了多功能,包括缓慢释放,智能响应发布,特别是具有强大的生物学效应来治疗各种疾病。在这次审查中,基于NPHM的超分子生物活性材料作为一种新兴的,革命性的,和有前途的战略。的发展,优势,和NPHM的局限性,以及NPHM基材料的有利地位,首先审查。随后,重点介绍了特定于七类NPHM的自组装策略的系统和全面分析。还提供了对NPHM结构特征对超分子材料形成的影响的见解。最后,总结了驱动程序和准备工作,强调生物医学应用,未来的科学挑战,和机会,希望为未来的研究和应用激发灵感。
Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties in preparation, side effects, and clinical translation. Recently, significant progress has been achieved in terms of direct self-assembly of natural products from herbal medicine (NPHM), an important source for novel medications, resulting in a wide range of bioactive supramolecular materials including gels, and nanoparticles. The NPHM-based supramolecular bioactive materials are produced from renewable resources, are simple to prepare, and have demonstrated multi-functionality including slow-release, smart-responsive release, and especially possess powerful biological effects to treat various diseases. In this review, NPHM-based supramolecular bioactive materials have been revealed as an emerging, revolutionary, and promising strategy. The development, advantages, and limitations of NPHM, as well as the advantageous position of NPHM-based materials, are first reviewed. Subsequently, a systematic and comprehensive analysis of the self-assembly strategies specific to seven major classes of NPHM is highlighted. Insights into the influence of NPHM structural features on the formation of supramolecular materials are also provided. Finally, the drivers and preparations are summarized, emphasizing the biomedical applications, future scientific challenges, and opportunities, with the hope of igniting inspiration for future research and applications.