■越来越多的证据表明,慢性阻塞性肺疾病(COPD)的微生物生态学与疾病的状态和严重程度密切相关,COPD和健康对照(HC)之间存在明显的微生物生态差异。本系统综述和荟萃分析旨在总结微生物多样性指数和分类单元的相对丰度,气道,并对不同阶段COPD和HC的肠道菌群进行比较。
■在PubMed上进行了全面系统的文献检索,Embase,WebofScience,和Cochrane图书馆数据库来识别相关的英语文章,气道,2003年至2023年5月8日发表的COPD中的肠道微生物群。有关微生物多样性指数和类群相对丰度的信息,气道,收集肠道菌群,以比较COPD和HC的不同阶段。
■本综述共纳入20项研究,共有337名HC参与者,511例COPD患者,154例AECOPD患者。我们观察到参与者组之间的α多样性没有显着差异,但在纳入研究的一半中,β多样性存在显著差异。与HC相比,普雷沃氏菌,链球菌,放线菌,SCOPD中口腔微生物群的Veillonella在属水平上减少。大多数研究支持嗜血杆菌,乳酸菌,假单胞菌增加了,但是Veillonella,普雷沃氏菌,放线菌,卟啉单胞菌,在SCOPD的气道微生物群中,Atobobium在属水平上减少。然而,丰富的嗜血杆菌,乳酸杆菌和假单胞菌属表现出增加,而与HC相比,放线菌和卟啉单胞菌显示AECOPD的气道微生物群减少。SCOPD中肠道菌群的Lachnospira在属水平上减少。
■大多数已发表的研究结果支持,与HC相比,COPD表现出降低的α多样性。然而,我们的荟萃分析没有证实这一点.为了进一步研究COPD患者口腔-气道-肠轴中微生物组的特征和作用机制,需要更大规模和更严格的研究。
■PROSPERO(https://www.crd.约克。AC.英国/繁荣/),标识符CRD42023418726。
UNASSIGNED: Increasing evidence indicates the microbial ecology of chronic obstructive pulmonary disease (COPD) is intricately associated with the disease\'s status and severity, and distinct microbial ecological variations exist between COPD and healthy control (HC). This systematic review and meta-analysis aimed to summarize microbial diversity indices and taxa relative abundance of oral, airway, and intestine microbiota of different stages of COPD and HC to make comparisons.
UNASSIGNED: A comprehensive systematic literature search was conducted in PubMed, Embase, the Web of Science, and the Cochrane Library databases to identify relevant English articles on the oral, airway, and intestine microbiota in COPD published between 2003 and 8 May 2023. Information on microbial diversity indices and taxa relative abundance of oral, airway, and intestine microbiota was collected for comparison between different stages of COPD and HC.
UNASSIGNED: A total of 20 studies were included in this review, involving a total of 337 HC participants, 511 COPD patients, and 154 AECOPD patients. We observed that no significant differences in alpha diversity between the participant groups, but beta diversity was significantly different in half of the included studies. Compared to HC, Prevotella, Streptococcus, Actinomyces, and Veillonella of oral microbiota in SCOPD were reduced at the genus level. Most studies supported that Haemophilus, Lactobacillus, and Pseudomonas were increased, but Veillonella, Prevotella, Actinomyces, Porphyromonas, and Atopobium were decreased at the genus level in the airway microbiota of SCOPD. However, the abundance of Haemophilus, Lactobacillus and Pseudomonas genera exhibited an increase, whereas Actinomyces and Porphyromonas showed a decrease in the airway microbiota of AECOPD compared to HC. And Lachnospira of intestine microbiota in SCOPD was reduced at the genus level.
UNASSIGNED: The majority of published research findings supported that COPD exhibited decreased alpha diversity compared to HC. However, our meta-analysis does not confirm it. In order to further investigate the characteristics and mechanisms of microbiome in the oral-airway- intestine axis of COPD patients, larger-scale and more rigorous studies are needed.
UNASSIGNED: PROSPERO (https://www.crd.york.ac.uk/prospero/), identifier CRD42023418726.