PDF(Pubmed)
Abstract：
Breast cancer is the most frequent kind of cancer and the second leading cause of mortality worldwide, behind heart disease. Next-generation sequencing technologies enables for unprecedented enumeration of human resident gut microorganisms, conferring novel insights into the role of the microbiota in health and individuals with breast cancer. A growing body of research on microbial dysbiosis seems to indicate an elevated risk of health complications including cancer. Although several dysbiosis indices have been proposed, their underlying methodology, as well as the cohorts and conditions of breast cancer patients are significantly different. To date, these indices have not yet been thoroughly reviewed especially when it comes to researching the estrogen-gut microbiota axis. Instead of providing a thorough rating of the most effective diversity measurements, the current work aims to be used to assess the relevance of each study\'s findings across the demographic data, different subtypes, and stages of breast cancer, and tie them to the estrobolome, which controls the amount of oestrogen that circulates through humans. This review will cover 11 studies which will go into a detailed discussion for the microbiome results of the mentioned studies, leaving to the user the final choice of the most suited indices as well as highlight the observed bacteria found to be related to the estrobolome in hopes of giving the reader a better understanding for the biological cross-talk between gut microbiome and breast cancer progression.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s12088-023-01135-z.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s12088-023-01135-z.
摘要：
乳腺癌是最常见的癌症，也是全球第二大死亡原因，心脏病背后下一代测序技术能够对人类肠道微生物进行前所未有的计数，为微生物群在健康和乳腺癌患者中的作用提供了新的见解。越来越多的关于微生物菌群失调的研究似乎表明，包括癌症在内的健康并发症的风险增加。尽管已经提出了几种生态失调指数，他们潜在的方法论，以及乳腺癌患者的队列和病情有显著差异。迄今为止,这些指标尚未得到全面审查，尤其是在研究雌激素-肠道微生物群轴方面。而不是提供最有效的多样性测量的全面评级，目前的工作旨在用于评估每个研究结果在人口统计数据中的相关性，不同的亚型，和乳腺癌的分期，把它们绑在estrobolome上，它控制着在人体内循环的雌激素量。这篇综述将涵盖11项研究，这些研究将详细讨论上述研究的微生物组结果，将最适合的指标的最终选择留给用户，并强调发现与estrobolome相关的观察细菌，以期使读者更好地了解肠道微生物组和乳腺癌进展之间的生物学串扰。
■在线版本包含补充材料，可在10.1007/s12088-023-01135-z获得。
■在线版本包含补充材料，可在10.1007/s12088-023-01135-z获得。
