背景:乳腺癌和乙型肝炎病毒(HBV)之间的相关性仍然没有定论。本研究旨在探讨不同年龄组女性乳腺癌患者HBV感染及既往感染的血清学状况,良性乳腺疾病患者,和接受常规体检的个人。
方法:收集并分析了2012年9月至2020年7月在重庆医科大学附属第一医院首次诊断的6072例女性乳腺癌患者的HBV血清学标志物的血清数据。以及同期接受常规体检的4019名良性乳腺疾病女性和54740名健康女性。数据按年龄分层,以进行组间比较。
结果:乳腺癌组中HBV感染和过去感染的患病率(7.9%,55.1%)高于良性乳腺疾病组(6.5%,39.1%)和健康女性组(5.0%,17.6%);乳腺癌组仅HBV表面抗体阳性率(HBsAb(+))(10.3%)低于良性乳腺疾病组(26.9%)和健康女性组(49.2%),三组间差异有统计学意义(p<0.05)。按年龄分层,乳腺癌组中HBV感染的患病率(8%,8.9%)和良性乳腺疾病组(7.75%,8.1%)高于健康女性组(4.5%,6.3%)在30-39岁和40-49岁年龄段,分别。乳腺癌组HBV过去感染率(24.8%,45.0%)高于良性乳腺疾病组(16.1%,35.4%)在≤29岁和30-39岁年龄组,分别。.在所有年龄组中,乳腺癌组的HBV过去感染率均高于健康女性组,而乳腺癌组仅HBsAb(+)的比率低于良性乳腺疾病组及各年龄组常规体检组。
结论:乳腺癌妇女和良性乳腺疾病妇女的乙肝病毒感染率和既往感染率较高,中年妇女之间的差异更大。乳腺癌妇女和良性乳腺疾病的妇女只有HBsAb(+)对HBV的发生率较低。
BACKGROUND: The correlation between breast cancer and hepatitis B virus (HBV) remains inconclusive. This study aims to explore the serological status of HBV infection and past infection in different age groups of female breast cancer patients, patients with benign breast diseases, and individuals undergoing routine physical examinations.
METHODS: Serum data on HBV serological markers were collected and analyzed from 6072 female breast cancer patients first diagnosed from September 2012 to July 2020 at the First Affiliated Hospital of Chongqing Medical University, along with 4019 women with benign breast diseases and 54,740 healthy females undergoing routine physical examinations in the same period. The data were stratified by age for comparison between groups.
RESULTS: The prevalence of HBV infection and past infection in the breast cancer group (7.9%, 55.1%) was higher than that in the benign breast disease group (6.5%, 39.1%) and the healthy females group(5.0%, 17.6%);the rate of only HBV surface antibody positivity (HBsAb ( +)) in the breast cancer group (10.3%) was lower than that in the benign breast disease group (26.9%) and the healthy females group (49.2%), with significant differences between the three groups (p < 0.05). Stratified by age, the prevalence of HBV infection in the breast cancer group (8%, 8.9%) and benign breast disease group (7.75%, 8.1%)was higher than that in the healthy females group (4.5%, 6.3%) in the 30-39 and 40-49 age group, respectively. The past infection rate of HBV in the breast cancer group (24.8%, 45.0%) was higher than that in the benign breast disease group (16.1%, 35.4%) in the ≤ 29 and 30-39 age group, respectively.. The past infection rate of HBV in the breast cancer group was higher than that in the healthy females group in all age groups, while the rate of only HBsAb ( +) in the breast cancer group was lower than that in the benign breast disease group and the routine physical examination group in all age groups.
CONCLUSIONS: Breast cancer women and women with benign breast diseases have higher rates of hepatitis B virus infection and previous infections, with more significant differences among middle-aged women. Breast cancer women and women with benign breast diseases have lower rates of only HBsAb ( +) for HBV.