目的:评价运动干预联合司来吉兰改善帕金森病(PD)患者冻结步态(FOG)的效果。
方法:对2020年1月至2023年1月富阳区第一人民医院收治的FOGPD患者60例进行回顾性分析。将患者分为对照组(n=28,单独使用司来吉兰治疗)和观察组(n=32,接受司来吉兰治疗和运动干预)。步态参数,FOG指数,电机和平衡功能,伯格平衡,心理状态,比较两组治疗前后的生活质量。
结果:治疗后,观察组表现出更长的步长,更高的步进速度,和较低的步进频率(分别为P=0.000,0.003,0.001),与对照组相比,较低的定时向上和Go测试和较高的Berg平衡量表得分表明平衡增强(分别为P=0.000,0.000)。观察组的贝克抑郁量表和贝克焦虑量表评分明显低于对照组(P=0.000、0.004)。此外,观察组的生活质量在帕金森病生活质量问卷的多个维度上表现出更好的生活质量,包括移动性,日常生活活动,情感幸福,污名,社会支持,认知,通信,和身体不适(P分别为0.000、0.000、0.000、0.000、0.017、0.000、0.000、0.000、0.000)高于对照组。
结论:运动干预和塞来吉林的组合有效地纠正了步态参数,增强平衡功能,缓解心理困扰,改善了患有FOG的PD患者的整体生活质量。
OBJECTIVE: To evaluate the efficacy of exercise interventions combined with Selegiline in ameliorating freezing of gait (FOG) in Parkinson\'s disease (PD) patients.
METHODS: A total of 60 PD patients with FOG treated in the First People\'s Hospital of Fuyang District from January 2020 to January 2023 were retrospectively collected and analyzed. Patients were divided into a control group (n = 28, treated with Selegiline alone) and an observation group (n = 32, treated with Selegiline and exercise interventions). Gait parameters, FOG indices, motor and balance functions, Berg Balance, psychological status, and quality of life were compared between the groups pre- and post-treatment.
RESULTS: After treatment, the observation group exhibited longer step length, higher step speed, and lower step frequency (P = 0.000, 0.003, 0.001, respectively), with enhanced balance as indicated by lower Timed Up and Go Test and higher Berg Balance Scale scores than the control group (P = 0.000, 0.000, respectively). The Beck Depression Inventory and Beck Anxiety Inventory scores were notably lower in the observation group than those in the control group (P = 0.000, 0.004, respectively). Additionally, the observation group showed better quality of life across several dimensions of the Parkinson\'s Disease Quality of Life Questionnaire, including mobility, activities of daily living, emotional well-being, stigma, social support, cognition, communication, and bodily discomfort (P = 0.000, 0.000, 0.000, 0.000, 0.017, 0.000, 0.000, 0.000, respectively) than the control group.
CONCLUSIONS: The combination of exercise interventions and Selegiline effectively rectifies the gait parameters, enhances the balance function, alleviates psychological distress, and improves the overall quality of life in PD patients experiencing FOG.