Abstract：
OBJECTIVE: To observe the effects of thunder-fire moxibustion on the balance function and musculoskeletal metabolism in female patients of primary osteoporosis (POP) with low muscle mass.
METHODS: Sixty female patients of POP with low muscle mass were randomly divided into an observation group (30 cases, 5 cases dropped out) and a control group (30 cases, 2 cases dropped out). The patients in the control group were treated with oral administration of Caltrate D (1.5 g calcium carbonate + 125 IU vitamin D3), one tablet per day for 12 weeks. In addition to the control treatment, the patients in the observation group were treated with thunder-fire moxibustion at Mingmen (GV 4), Yaoyangguan (GV 3), bilateral Ganshu (BL 18), Shenshu (BL 23), and Dachangshu (BL 25), 30 min per acupoint, once every other day, three times a week, for 12 weeks. Balance function indexes (95% confidence ellipse area of the center of pressure [COP], total displacement, average speed), lumbar pain visual analogue scale (VAS), serum muscle metabolism factors (myostatin [MSTN], peroxisome proliferator-activated receptor γ coactivator-1α [PGC-1α]) and bone metabolism factors (aminoterminal propeptide typeⅠ procollagen [PINP], C-terminal telopeptide of typeⅠcollagen [CTX-Ⅰ]) were compared before and after treatment in both groups.
RESULTS: Compared before treatment, the 95% confidence ellipse area of COP, total displacement, and average speed in the observation group were decreased after treatment (P<0.01), and the above indexes in the observation group were lower than those in the control group (P<0.05). Compared before treatment, the VAS scores in both groups were decreased after treatment (P<0.01), the score in the observation group was lower than that in the control group (P<0.01). Compared before treatment, the serum levels of MSTN, PINP and CTX-Ⅰ in the observation group were reduced after treatment (P<0.01), while the serum level of PGC-1α was increased (P<0.01). The control group showed a decrease in serum level of MSTN (P<0.05). The observation group had lower serum levels of MSTN and PINP (P<0.05) and higher serum level of PGC-1α (P<0.01) compared to the control group.
CONCLUSIONS: The thunder-fire moxibustion can effectively relieve lumbar pain, improve balance function, and regulate musculoskeletal metabolism in female patients of POP with low muscle mass.
目的：观察雷火灸对原发性骨质疏松症（POP）伴低肌肉质量女性患者平衡功能和肌骨代谢水平的影响。方法：将60例POP伴低肌肉质量女性患者随机分为观察组（30例，脱落5例）和对照组（30例，脱落2例）。对照组予钙尔奇D（1.5 g碳酸钙＋125 IU维生素D3）口服，每次1片，每天1次，共治疗12周；观察组在对照组基础上予雷火灸治疗，穴取命门、腰阳关及双侧肝俞、肾俞、大肠俞，每穴艾灸30 min，隔日１次，每周３次，共治疗12周。比较两组患者治疗前后平衡功能指标[足底压力中心（COP）95％置信椭圆面积、总位移、平均速度]及腰部疼痛视觉模拟量表（VAS）评分，检测两组患者治疗前后血清肌肉代谢因子[肌肉生长抑制素（MSTN）、过氧化物酶体增殖物激活受体γ辅激活因子1α（PGC-1α）]和骨代谢因子[Ⅰ型胶原N端前肽（PINP）、Ⅰ型胶原C末端交联肽（CTX-Ⅰ）]水平。结果：治疗后，观察组患者COP 95％置信椭圆面积、总位移、平均速度均较治疗前降低（P<0.01），且观察组低于对照组（P<0.05）；两组患者腰部VAS评分均较治疗前降低（P<0.01），且观察组低于对照组（P<0.01）。治疗后，观察组患者血清MSTN、PINP、CTX-Ⅰ水平较治疗前降低（P<0.01），血清PGC-1α水平较治疗前升高（P<0.01），对照组患者血清MSTN水平降低（P<0.05）；观察组患者血清MSTN、PINP水平低于对照组（P<0.05），血清PGC-1α水平高于对照组（P<0.01）。结论：雷火灸可有效缓解POP伴低肌肉质量女性患者腰部疼痛，改善平衡功能，并调节肌骨代谢水平。.
METHODS: Sixty female patients of POP with low muscle mass were randomly divided into an observation group (30 cases, 5 cases dropped out) and a control group (30 cases, 2 cases dropped out). The patients in the control group were treated with oral administration of Caltrate D (1.5 g calcium carbonate + 125 IU vitamin D3), one tablet per day for 12 weeks. In addition to the control treatment, the patients in the observation group were treated with thunder-fire moxibustion at Mingmen (GV 4), Yaoyangguan (GV 3), bilateral Ganshu (BL 18), Shenshu (BL 23), and Dachangshu (BL 25), 30 min per acupoint, once every other day, three times a week, for 12 weeks. Balance function indexes (95% confidence ellipse area of the center of pressure [COP], total displacement, average speed), lumbar pain visual analogue scale (VAS), serum muscle metabolism factors (myostatin [MSTN], peroxisome proliferator-activated receptor γ coactivator-1α [PGC-1α]) and bone metabolism factors (aminoterminal propeptide typeⅠ procollagen [PINP], C-terminal telopeptide of typeⅠcollagen [CTX-Ⅰ]) were compared before and after treatment in both groups.
RESULTS: Compared before treatment, the 95% confidence ellipse area of COP, total displacement, and average speed in the observation group were decreased after treatment (P<0.01), and the above indexes in the observation group were lower than those in the control group (P<0.05). Compared before treatment, the VAS scores in both groups were decreased after treatment (P<0.01), the score in the observation group was lower than that in the control group (P<0.01). Compared before treatment, the serum levels of MSTN, PINP and CTX-Ⅰ in the observation group were reduced after treatment (P<0.01), while the serum level of PGC-1α was increased (P<0.01). The control group showed a decrease in serum level of MSTN (P<0.05). The observation group had lower serum levels of MSTN and PINP (P<0.05) and higher serum level of PGC-1α (P<0.01) compared to the control group.
CONCLUSIONS: The thunder-fire moxibustion can effectively relieve lumbar pain, improve balance function, and regulate musculoskeletal metabolism in female patients of POP with low muscle mass.
目的：观察雷火灸对原发性骨质疏松症（POP）伴低肌肉质量女性患者平衡功能和肌骨代谢水平的影响。方法：将60例POP伴低肌肉质量女性患者随机分为观察组（30例，脱落5例）和对照组（30例，脱落2例）。对照组予钙尔奇D（1.5 g碳酸钙＋125 IU维生素D3）口服，每次1片，每天1次，共治疗12周；观察组在对照组基础上予雷火灸治疗，穴取命门、腰阳关及双侧肝俞、肾俞、大肠俞，每穴艾灸30 min，隔日１次，每周３次，共治疗12周。比较两组患者治疗前后平衡功能指标[足底压力中心（COP）95％置信椭圆面积、总位移、平均速度]及腰部疼痛视觉模拟量表（VAS）评分，检测两组患者治疗前后血清肌肉代谢因子[肌肉生长抑制素（MSTN）、过氧化物酶体增殖物激活受体γ辅激活因子1α（PGC-1α）]和骨代谢因子[Ⅰ型胶原N端前肽（PINP）、Ⅰ型胶原C末端交联肽（CTX-Ⅰ）]水平。结果：治疗后，观察组患者COP 95％置信椭圆面积、总位移、平均速度均较治疗前降低（P<0.01），且观察组低于对照组（P<0.05）；两组患者腰部VAS评分均较治疗前降低（P<0.01），且观察组低于对照组（P<0.01）。治疗后，观察组患者血清MSTN、PINP、CTX-Ⅰ水平较治疗前降低（P<0.01），血清PGC-1α水平较治疗前升高（P<0.01），对照组患者血清MSTN水平降低（P<0.05）；观察组患者血清MSTN、PINP水平低于对照组（P<0.05），血清PGC-1α水平高于对照组（P<0.01）。结论：雷火灸可有效缓解POP伴低肌肉质量女性患者腰部疼痛，改善平衡功能，并调节肌骨代谢水平。.
摘要：
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