■动脉硬化指数,定义为非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇(NHHR)的比率,已经成为各种疾病的新型生物标志物。NHHR与腰椎矿物质密度(BMD)之间的关系尚未得到检查。
■这项横断面研究分析了2011-2018年国家健康与营养调查(NHANES)的数据。NHHR计算为(总胆固醇-高密度脂蛋白胆固醇)/高密度脂蛋白胆固醇。将腰椎BMD计算为Z评分。加权多元线性回归,亚组分析,相互作用分析,广义加法模型,并采用两分段线性回归。
■共包括8602名参与者。NHHR与腰椎BMD之间的负相关是一致且显着的(模型1:β=-0.039,95%CI:-0.055,-0.023,p<0.001;模型2:β=-0.045,95%CI:-0.062,-0.027,p<0.001;模型3:β=-0.042,95%CI:-0.061,-0.023,p<0.001)。NHHR与腰椎BMD之间的线性关系受体重指数(相互作用p=0.012)和高血压(相互作用p=0.047)的显着影响。在特定人群中观察到NHHR和腰椎BMDZ评分之间的非线性关联,包括U形,倒U形,L形,倒L形,更年期女性之间的U型关系,体重不足的参与者,那些糖耐量受损的人,那些患有糖尿病和服用抗高脂血症药物的人,分别。
■NHHR与腰椎BMD呈负相关,但在特定人群中有所不同。这些发现表明,NHHR应根据个人水平进行调整,以通过个性化方法减轻骨质流失。心血管疾病风险增加的个体应关注他们的骨骼健康。
UNASSIGNED: The arteriosclerosis index, defined as the ratio of non-high density lipoprotein cholesterol to high density lipoprotein cholesterol (NHHR), has emerged as a novel biomarker for various diseases. The relationship between NHHR and lumbar bone mineral density (BMD) has not been previously examined.
UNASSIGNED: This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2011-2018. NHHR was calculated as (total cholesterol-high-density lipoprotein cholesterol)/high-density lipoprotein cholesterol. Lumbar BMD was calculated to Z scores. Weighted multivariate linear regression, subgroup analysis, interaction analysis, generalized additive model, and two-piecewise linear regression were used.
UNASSIGNED: A total of 8,602 participants were included. The negative association between NHHR and lumbar BMD was consistent and significant (Model 1: β = -0.039, 95% CI: -0.055, -0.023, p < 0.001; Model 2: β = -0.045, 95% CI: -0.062, -0.027, p < 0.001; Model 3: β = -0.042, 95% CI: -0.061, -0.023, p < 0.001). The linear relationship between NHHR and lumbar BMD was significantly influenced by body mass index (p for interaction = 0.012) and hypertension (p for interaction = 0.047). Non-linear associations between NHHR and lumbar BMD Z scores were observed in specific populations, including U-shaped, reverse U-shaped, L-shaped, reverse L-shaped, and U-shaped relationships among menopausal females, underweight participants, those with impaired glucose tolerance, those with diabetes mellitus and those taking anti-hyperlipidemic drugs, respectively.
UNASSIGNED: NHHR exhibited a negative association with lumbar BMD, but varying across specific populations. These findings suggest that NHHR should be tailored to individual levels to mitigate bone loss through a personalized approach. Individuals at heightened risk of cardiovascular disease should focus on their bone health.