背景:肥胖代谢综合征(MetS)具有显著的死亡率和发病率。探讨了阿育吠陀综合管理的可能效果。
目的:评估Tryushnadichrona在肥胖代谢综合征治疗中的作用。
方法:研究是一项随机研究,受控,双盲,平行组比较临床试验。研究中招募了符合国家胆固醇教育计划成人治疗小组3诊断标准的48名参与者。他们分为两组。安慰剂组每天两次服用1克安慰剂,阿育吠陀饮食和瑜伽。Tryushnadi集团每天两次接受Tryushnadichurna1gm的干预,阿育吠陀饮食和瑜伽。干预时间为90天。评估标准包括体重,BMI,腰围(WC),腰臀比,蒙皮褶皱厚度(SFT),身体脂肪,血压,WHO-QOLBREF量表,临床总体印象量表(CGI)-严重程度,全球改善和功效指数,每30天评估空腹血糖(FBS)。其他血液参数,如糖化血红蛋白(HbA1c),甘油三酯,高密度脂蛋白(HDL),低密度脂蛋白(LDL),在研究前和研究后评估总胆固醇(TC)。
结果:组间比较显示,Tryushnadi组的BMI有显著改善,重量,WHOQOL-Bref并具有较大的效应大小。两组均表现出WC改善,身体脂肪,SFT,CGI严重性,组内CGI疗效指数和生活质量改善评估。
结论:研究表明Tryushnadichurna对肥胖患者的MetS管理有效。阿育吠陀医学的综合管理,阿育吠陀饮食和瑜伽有有益的效果。
BACKGROUND: Metabolic syndrome (MetS) with obesity has significant mortality and morbidity. Integrative
Ayurveda management is explored for it\'s possible effect.
OBJECTIVE: To evaluate the effect of Tryushnadi churna in the management of Metabolic syndrome with obesity.
METHODS: Study is a Randomized, Controlled, double blind, parallel group comparative clinical trial. 48 participants meeting the National Cholesterol Education Programme Adult Treatment panel 3 diagnostic criteria were recruited in the study. They were divided in two 2 groups. Placebo group were administered with Placebo 1 gm twice a day,
Ayurveda diet and yoga. Tryushnadi Group were intervened with Tryushnadi churna 1 gm twice a day,
Ayurveda diet and yoga. Interventions were for 90 days. Assessments criteria included Weight, BMI,Waist circumference (WC), Waist hip ratio, Skin fold thickness (SFT), Body fat, blood pressure, WHO-QOL BREF scale, Clinical Global Impression Scale (CGI)- Severity, Global improvement and Efficacy index, Fasting blood sugar (FBS) were assessed on every 30th day. Other blood parameters like Glycated haemoglobin (HbA1c), Triglycerides, High density lipoproteins (HDL), Low density lipoproteins (LDL), Total cholesterol (TC) were evaluated at pre and post study.
RESULTS: Between groups comparison showed, Tryushnadi group had significant improvements in BMI, Weight, WHOQOL-Bref and had large effect size. Both the groups showed improvement in WC, body fat, SFT, CGI severity, CGI efficacy index and improvement in quality of life in within group assessment.
CONCLUSIONS: Study showed that Tryushnadi churna was effective in management of MetS with Obesity. Integrated management of
Ayurveda medicine,
Ayurveda diet and yoga had beneficial effect.