The increasing usage of interconnected devices within the Internet of Things (IoT) and Industrial IoT (IIoT) has significantly enhanced efficiency and utility in both personal and industrial settings but also heightened cybersecurity vulnerabilities, particularly through IoT malware. This paper explores the use of one-class classification, a method of unsupervised learning, which is especially suitable for unlabeled data, dynamic environments, and malware detection, which is a form of anomaly detection. We introduce the TF-IDF method for transforming nominal features into numerical formats that avoid information loss and manage dimensionality effectively, which is crucial for enhancing pattern recognition when combined with n-grams. Furthermore, we compare the performance of multi-class vs. one-class classification models, including Isolation Forest and deep autoencoder, that are trained with both benign and malicious NetFlow samples vs. trained exclusively on benign NetFlow samples. We achieve 100% recall with precision rates above 80% and 90% across various test datasets using one-class classification. These models show the adaptability of unsupervised learning, especially one-class classification, to the evolving malware threats in the IoT domain, offering insights into enhancing IoT security frameworks and suggesting directions for future research in this critical area.

Network traffic anomaly detection, as an effective analysis method for network security, can identify differentiated traffic information and provide secure operation in complex and changing network environments. To avoid information loss caused when handling traffic data while improving the detection performance of traffic feature information, this paper proposes a multi-information fusion model based on a convolutional neural network and AutoEncoder. The model uses a convolutional neural network to extract features directly from the raw traffic data, and a AutoEncoder to encode the statistical features extracted from the raw traffic data, which are used to supplement the information loss due to cropping. These two features are combined to form a new integrated feature for network traffic, which has the load information from the original traffic data and the global information of the original traffic data obtained from the statistical features, thus providing a complete representation of the information contained in the network traffic and improving the detection performance of the model. The experiments show that the classification accuracy of network traffic anomaly detection using this model outperforms that of classical machine learning methods.

The identification of plant leaf diseases is crucial in precision agriculture, playing a pivotal role in advancing the modernization of agriculture. Timely detection and diagnosis of leaf diseases for preventive measures significantly contribute to enhancing both the quantity and quality of agricultural products, thereby fostering the in-depth development of precision agriculture. However, despite the rapid development of research on plant leaf disease identification, it still faces challenges such as insufficient agricultural datasets and the problem of deep learning-based disease identification models having numerous training parameters and insufficient accuracy. This paper proposes a plant leaf disease identification method based on improved SinGAN and improved ResNet34 to address the aforementioned issues. Firstly, an improved SinGAN called Reconstruction-Based Single Image Generation Network (ReSinGN) is proposed for image enhancement. This network accelerates model training speed by using an autoencoder to replace the GAN in the SinGAN and incorporates a Convolutional Block Attention Module (CBAM) into the autoencoder to more accurately capture important features and structural information in the images. Random pixel Shuffling are introduced in ReSinGN to enable the model to learn richer data representations, further enhancing the quality of generated images. Secondly, an improved ResNet34 is proposed for plant leaf disease identification. This involves adding CBAM modules to the ResNet34 to alleviate the limitations of parameter sharing, replacing the ReLU activation function with LeakyReLU activation function to address the problem of neuron death, and utilizing transfer learning-based training methods to accelerate network training speed. This paper takes tomato leaf diseases as the experimental subject, and the experimental results demonstrate that: (1) ReSinGN generates high-quality images at least 44.6 times faster in training speed compared to SinGAN. (2) The Tenengrad score of images generated by the ReSinGN model is 67.3, which is improved by 30.2 compared to the SinGAN, resulting in clearer images. (3) ReSinGN model with random pixel Shuffling outperforms SinGAN in both image clarity and distortion, achieving the optimal balance between image clarity and distortion. (4) The improved ResNet34 achieved an average recognition accuracy, recognition precision, recognition accuracy (redundant as it\'s similar to precision), recall, and F1 score of 98.57, 96.57, 98.68, 97.7, and 98.17%, respectively, for tomato leaf disease identification. Compared to the original ResNet34, this represents enhancements of 3.65, 4.66, 0.88, 4.1, and 2.47%, respectively.

UNASSIGNED: The aim of this study was to develop a predictive model for uncorrected/actual fluid intelligence scores in 9-10 year old children using magnetic resonance T1-weighted imaging. Explore the predictive performance of an autoencoder model based on reconstruction regularization for fluid intelligence in adolescents.
UNASSIGNED: We collected actual fluid intelligence scores and T1-weighted MRIs of 11,534 adolescents who completed baseline tasks from ABCD Data Release 3.0. A total of 148 ROIs were selected and 604 features were proposed by FreeSurfer segmentation. The training and testing sets were divided in a ratio of 7:3. To predict fluid intelligence scores, we used AE, MLP and classic machine learning models, and compared their performance on the test set. In addition, we explored their performance across gender subpopulations. Moreover, we evaluated the importance of features using the SHapley Additive Explain method. Results: The proposed model achieves optimal performance on the test set for predicting actual fluid intelligence scores (PCC = 0.209 ± 0.02, MSE = 105.212 ± 2.53). Results show that autoencoders with refactoring regularization are significantly more effective than MLPs and classical machine learning models. In addition, all models performed better on female adolescents than on male adolescents. Further analysis of relevant characteristics in different populations revealed that this may be related to gender differences in underlying fluid intelligence mechanisms.
UNASSIGNED: We construct a weak but stable correlation between brain structural features and raw fluid intelligence using autoencoders. Future research may need to explore ensemble regression strategies utilizing multiple machine learning algorithms on multimodal data in order to improve the predictive performance of fluid intelligence based on neuroimaging features.

UNASSIGNED: Radiography plays an important role in medical care, and accurate positioning is essential for providing optimal quality images. Radiographs with insufficient diagnostic value are rejected, and retakes are required. However, determining the suitability of retaking radiographs is a qualitative evaluation.
UNASSIGNED: To evaluate skull radiograph accuracy automatically using an unsupervised learning-based autoencoder (AE) and a variational autoencoder (VAE). In this study, we eliminated visual qualitative evaluation and used unsupervised learning to identify skull radiography retakes from the quantitative evaluation.
UNASSIGNED: Five skull phantoms were imaged on radiographs, and 1,680 images were acquired. These images correspond to two categories: normal images captured at appropriate positions and images captured at inappropriate positions. This study verified the discriminatory ability of skull radiographs using anomaly detection methods.
UNASSIGNED: The areas under the curves for AE and VAE were 0.7060 and 0.6707, respectively, in receiver operating characteristic analysis. Our proposed method showed a higher discrimination ability than those of previous studies which had an accuracy of 52%.
UNASSIGNED: Our findings suggest that the proposed method has high classification accuracy in determining the suitability of retaking skull radiographs. Automation of optimal image consideration, whether or not to retake radiographs, contributes to improving operational efficiency in busy X-ray imaging operations.

OBJECTIVE: In patients having naïve glioblastoma multiforme (GBM), this study aims to assess the efficacy of Deep Learning algorithms in automating the segmentation of brain magnetic resonance (MR) images to accurately determine 3D masks for 4 distinct regions: enhanced tumor, peritumoral edema, non-enhanced/necrotic tumor, and total tumor.
METHODS: A 3D U-Net neural network algorithm was developed for semantic segmentation of GBM. The training dataset was manually delineated by a group of expert neuroradiologists on MR images from the Brain Tumor Segmentation Challenge 2021 (BraTS2021) image repository, as ground truth labels for diverse glioma (GBM and low-grade glioma) subregions across four MR sequences (T1w, T1w-contrast enhanced, T2w, and FLAIR) in 1251 patients. The in-house test was performed on 50 GBM patients from our cohort (PerProGlio project). By exploring various hyperparameters, the network\'s performance was optimized, and the most optimal parameter configuration was identified. The assessment of the optimized network\'s performance utilized Dice scores, precision, and sensitivity metrics.
RESULTS: Our adaptation of the 3D U-net with additional residual blocks demonstrated reliable performance on both the BraTS2021 dataset and the in-house PerProGlio cohort, employing only T1w-ce sequences for enhancement and non-enhanced/necrotic tumor models and T1w-ce + T2w + FLAIR for peritumoral edema and total tumor. The mean Dice scores (training and test) were 0.89 and 0.75; 0.75 and 0.64; 0.79 and 0.71; and 0.60 and 0.55, for total tumor, edema, enhanced tumor, and non-enhanced/necrotic tumor, respectively.
CONCLUSIONS: The results underscore the high precision with which our network can effectively segment GBM tumors and their distinct subregions. The level of accuracy achieved agrees with the coefficients recorded in previous GBM studies. In particular, our approach allows model specialization for each of the different tumor subregions employing only those MR sequences that provide value for segmentation.

Increasing research findings suggest that circular RNA (circRNA) exerts a crucial function in the pathogenesis of complex human diseases by binding to miRNA. Identifying their potential interactions is of paramount importance for the diagnosis and treatment of diseases. However, long cycles, small scales, and time-consuming processes characterize previous biological wet experiments. Consequently, the use of an efficient computational model to forecast the interactions between circRNA and miRNA is gradually becoming mainstream. In this study, we present a new prediction model named BJLD-CMI. The model extracts circRNA sequence features and miRNA sequence features by applying Jaccard and Bert\'s method and organically integrates them to obtain CMI attribute features, and then uses the graph embedding method Line to extract CMI behavioral features based on the known circRNA-miRNA correlation graph information. And then we predict the potential circRNA-miRNA interactions by fusing the multi-angle feature information such as attribute and behavior through Autoencoder in Autoencoder Networks. BJLD-CMI attained 94.95% and 90.69% of the area under the ROC curve on the CMI-9589 and CMI-9905 datasets. When compared with existing models, the results indicate that BJLD-CMI exhibits the best overall competence. During the case study experiment, we conducted a PubMed literature search to confirm that out of the top 10 predicted CMIs, seven pairs did indeed exist. These results suggest that BJLD-CMI is an effective method for predicting interactions between circRNAs and miRNAs. It provides a valuable candidate for biological wet experiments and can reduce the burden of researchers.

Preprocessing plays a key role in Raman spectral analysis. However, classical preprocessing algorithms often have issues with reducing Raman peak intensities and changing the peak shape when processing spectra. This paper introduces a unified solution for preprocessing based on a convolutional autoencoder to enhance Raman spectroscopy data. One is a denoising algorithm that uses a convolutional denoising autoencoder (CDAE model), and the other is a baseline correction algorithm based on a convolutional autoencoder (CAE+ model). The CDAE model incorporates two additional convolutional layers in its bottleneck layer for enhanced noise reduction. The CAE+ model not only adds convolutional layers at the bottleneck but also includes a comparison function after the decoding for effective baseline correction. The proposed models were validated using both simulated spectra and experimental spectra measured with a Raman spectrometer system. Comparing their performance with that of traditional signal processing techniques, the results of the CDAE-CAE+ model show improvements in noise reduction and Raman peak preservation.

Accurately detecting defects while reconstructing a high-quality normal background in surface defect detection using unsupervised methods remains a significant challenge. This study proposes an unsupervised method that effectively addresses this challenge by achieving both accurate defect detection and a high-quality normal background reconstruction without noise. We propose an adaptive weighted structural similarity (AW-SSIM) loss for focused feature learning. AW-SSIM improves structural similarity (SSIM) loss by assigning different weights to its sub-functions of luminance, contrast, and structure based on their relative importance for a specific training sample. Moreover, it dynamically adjusts the Gaussian window\'s standard deviation (σ) during loss calculation to balance noise reduction and detail preservation. An artificial defect generation algorithm (ADGA) is proposed to generate an artificial defect closely resembling real ones. We use a two-stage training strategy. In the first stage, the model trains only on normal samples using AW-SSIM loss, allowing it to learn robust representations of normal features. In the second stage of training, the weights obtained from the first stage are used to train the model on both normal and artificially defective training samples. Additionally, the second stage employs a combined learned Perceptual Image Patch Similarity (LPIPS) and AW-SSIM loss. The combined loss helps the model in achieving high-quality normal background reconstruction while maintaining accurate defect detection. Extensive experimental results demonstrate that our proposed method achieves a state-of-the-art defect detection accuracy. The proposed method achieved an average area under the receiver operating characteristic curve (AuROC) of 97.69% on six samples from the MVTec anomaly detection dataset.

Since scientific investigations have demonstrated that aberrant expression of miRNAs brings about the incidence of numerous intricate diseases, precise determination of miRNA-disease relationships greatly contributes to the advancement of human medical progress. To tackle the issue of inefficient conventional experimental approaches, numerous computational methods have been proposed to predict miRNA-disease association with enhanced accuracy. However, constructing miRNA-gene-disease heterogeneous network by incorporating gene information has been relatively under-explored in existing computational techniques. Accordingly, this paper puts forward a technique to predict miRNA-disease association by applying autoencoder and implementing random walk on miRNA-gene-disease heterogeneous network(AE-RW). Firstly, we integrate association information and similarities between miRNAs, genes, and diseases to construct a miRNA-gene-disease heterogeneous network. Subsequently, we consolidate two network feature representations extracted independently via an autoencoder and a random walk procedure. Finally, deep neural network(DNN) are utilized to conduct association prediction. The experimental results demonstrate that the AE-RW model achieved an AUC of 0.9478 through 5-fold CV on the HMDD v3.2 dataset, outperforming the five most advanced existing models. Additionally, case studies were implemented for breast and lung cancer, further validated the superior predictive capabilities of our model.