这篇综述文章全面探讨了促食欲和促食欲肽在伴侣动物肥胖管理中的作用,专注于临床应用。家畜肥胖,尤其是狗和猫,普遍存在,对他们的健康和福祉有重大影响。导致肥胖的因素包括过度喂养,劣质饮食,缺乏体力活动,和遗传倾向。尽管这种情况很严重,它经常被低估,社会观念有时会强化不健康的行为。了解食物摄入的调节和确定影响食物摄入相关蛋白功能的因素对于对抗肥胖至关重要。这些蛋白质的失调,无论是由于基因突变,酶学功能障碍,或者受体异常,会对健康产生深远的影响。分子生物学技术在阐明这些机制中起着关键作用,提供潜在治疗干预措施的见解。该综述将与食物摄入相关的蛋白质分为食欲肽(食物摄入的抑制剂)和食欲肽(食物摄入的增强剂)。它彻底检查了当前关于调节伴侣动物能量平衡的研究,强调各种肽的临床应用,包括ghrelin,phoenixin(PNX),asprosin,胰高血糖素样肽1(GLP-1),瘦素,和nesfatin-1,在兽医肥胖管理。这篇全面的综述旨在为肽之间的复杂相互作用提供有价值的见解,能量平衡调节,和伴侣动物的肥胖。它强调了有针对性的干预措施的重要性,并强调了基于肽的疗法在改善肥胖宠物健康结果方面的潜力。
This review article comprehensively explores the role of orexigenic and anorexigenic peptides in the management of obesity in companion animals, with a focus on clinical applications. Obesity in domestic animals, particularly dogs and cats, is prevalent, with significant implications for their health and well-being. Factors contributing to obesity include overfeeding, poor-quality diet, lack of physical activity, and genetic predispositions. Despite the seriousness of this condition, it is often underestimated, with societal perceptions sometimes reinforcing unhealthy behaviors. Understanding the regulation of food intake and identifying factors affecting the function of food intake-related proteins are crucial in combating obesity. Dysregulations in these proteins, whether due to genetic mutations, enzymatic dysfunctions, or receptor abnormalities, can have profound health consequences. Molecular biology techniques play a pivotal role in elucidating these mechanisms, offering insights into potential therapeutic interventions. The review categorizes food intake-related proteins into anorexigenic peptides (inhibitors of food intake) and orexigenic peptides (enhancers of food intake). It thoroughly examines current research on regulating energy balance in companion animals, emphasizing the clinical application of various peptides, including ghrelin, phoenixin (PNX), asprosin, glucagon-like peptide 1 (GLP-1), leptin, and nesfatin-1, in veterinary obesity management. This comprehensive review aims to provide valuable insights into the complex interplay between peptides, energy balance regulation, and obesity in companion animals. It underscores the importance of targeted interventions and highlights the potential of peptide-based therapies in improving the health outcomes of obese pets.