Anthropometric index

  • 文章类型: Journal Article
    糖尿病会导致神经损伤,血管问题,减少流向脚部等器官的血液,导致足部畸形和溃疡由于高葡萄糖水平。像DASH这样的健康饮食模式可以改善胰岛素敏感性和体重减轻。由于有限的数据和罕见的证据,我们的研究旨在探讨DASH饮食依从性与人体测量学之间的关系,心血管,和足部溃疡指标。
    该研究包括339名患有足部溃疡的糖尿病患者(122名女性和217名男性)。该研究收集了患者饮食摄入量的数据,人体测量,生物化学,足部溃疡,和新的动脉粥样硬化危险因素根据国际定义。
    在DASH指数的三分位数中,参与者的平均BMI为29.2±5.0、28.1±4.3和28.2±4.2(P值:0.18)。通过增加对DASH指数的坚持,单丝评分无明显变化OR:1.47;CI:(0.81-2.67).此外,足部溃疡面积在DASH四分位数之间无明显变化OR:1.01;CI:(0.56-1.83).DASH三元之间的动脉粥样硬化危险因素也有所下降,但统计意义不大。
    DASH依从性没有显著改变神经病变评分和胆总管指数及心血管危险因素,对足部溃疡大小无显著影响。
    UNASSIGNED: Diabetes can cause nerve damage, vascular issues, and reduced blood flow to organs such as the feet, leading to foot deformities and ulcers due to high glucose levels. A healthy dietary pattern like DASH can improve insulin sensitivity and weight loss. Due to limited data and rare evidence, our study aims to investigate the relationship between DASH diet adherence and anthropometric, cardiovascular, and foot ulcer indicators.
    UNASSIGNED: The study included 339 diabetic patients with foot ulcers (122 females and 217 males). The study gathered data on patient dietary intake, anthropometric measurements, biochemistry, foot ulcers, and novel atherogenic risk factors per international definitions.
    UNASSIGNED: The average BMI of the participants was 29.2 ± 5.0, 28.1 ± 4.3, and 28.2 ± 4.2 in the tertiles of DASH index (P-value: 0.18). By increasing the adherence to the DASH index, the monofilament score did not change significantly OR: 1.47; CI: (0.81-2.67). Also, foot ulcer area did not change significantly between DASH tertiles OR: 1.01; CI: (0.56-1.83). Atherogenic risk factors also decreased among the DASH tertiles, but statistically not significant.
    UNASSIGNED: DASH adherence did not change neuropathy score and cholindex and cardiovascular risk factors significantly and has no significant effect on foot ulcer size.
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  • 文章类型: Journal Article
    营养状况是儿童身心发育不当的最重要原因之一。该研究试图根据年龄体重人体测量指数(z评分)评估影响6-59个月儿童营养不良严重程度的因素,并研究了kebeles水平之间儿童营养状况决定因素的差异。以社区为基础,横断面研究设计于2022年10月12日至11月12日进行.通过应用多阶段聚类抽样技术,考虑了397名6-59个月的儿童的异质性,使用了样本。数据通过SPSS输入,并使用R版本3.4.0和STATA14.2统计软件包使用多水平有序逻辑回归模型进行分析,并在5%的显着性水平下进行推断。结果表明,出生间隔≥24个月(OR=1.431253,95%CI1.2213371.6763421,P值=0.008),家庭经济状况中等(OR=16.21466,95%CI1.2214031.423929,P值=0.000),富裕家庭的经济状况(OR=223.2856,95%CI1.342952.582325,P值=0.000),失业母亲的就业状况(OR=0.2291348,95%CI0.05295110.9966281,P值=0.049),无厕所设施(灌木丛场)(OR=0.3163329,95%CI0.18253560.5481975,P值=0.000),家庭成员数量(OR=0.9100682,95%CI0.83134810.9967315,P值=0.042),母乳喂养<12个月(OR=0.53803,95%CI0.3223150.898135,P值=0.018),父亲的教育程度小学(OR=4.601687,95%CI1.7580092.22053,P值=0.000),父亲的文化程度中学以上(OR=99.65229,95%CI2.5335024.788896,P值=0.000)和地理区域(kebeles)被发现是影响6至59个月儿童营养状况的重要因素。总体变化的15%归因于Kebeles水平,根据两级多级序数逻辑回归,Kebeles水平引起的变异估计值等于0.569,组内相关系数为0.15。由于具有随机系数的响应变量随机截距模型的性质,该数据在预测6-59个月儿童营养不良的严重状况时充分拟合,用于多水平有序逻辑回归模型分析。所以,研究人员建议实施初级保健和营养计划,以适应ItangSpecialWoreda的每个kebeles特征,以保护儿童免受营养缺乏。
    Nutritional status is one of the most important causes of improper physical and mental development in children. The study attempts to assess the factors affecting the severity status of children aged 6-59 months\' malnutrition based on the weight-for-age anthropometric index (z-score) and examine between-kebeles-level differences in determinants of the nutritional status of children. A community-based, cross-sectional study design was conducted from October 12 to November 12, 2022. A sample of 397 children aged 6-59 months primary data by applying multi-stage clustered sampling technique was used by considering their heterogeneity. The data were entered by SPSS and analyzed by using R version 3.4.0 and STATA 14.2 statistical software package using a multilevel ordinal logistic regression model and inferences were conducted at a 5% significance level. The results show that birth interval ≥ 24 months (OR = 1.431253, 95% CI 1.221337 1.6763421, P-value = 0.008), economic status of households medium (OR = 16.21466, 95% CI 1.221403 1.423929, P-value = 0.000), economic status of households rich (OR = 223.2856, 95% CI 1.34295 2.582325, P-value = 0.000), employment status of the mother unemployed (OR = 0.2291348, 95% CI 0.0529511 0.9966281, P-value = 0.049), No toilet facility (bush field) (OR = 0.3163329, 95% CI 0.1825356 0.5481975, P-value = 0.000), number of household members (OR = 0.9100682, 95% CI 0.8313481 0.9967315, P-value = 0.042), breastfeeding < 12 months (OR = 0.53803, 95% CI 0.322315 0.898135, P-value = 0.018), educational level of father Primary (OR = 4.601687, 95% CI 1.758009 2.22053, P-value = 0.000), educational level of father Secondary above (OR = 99.65229, 95% CI 2.533502 4.788896, P-value = 0.000) and geographical area (kebeles) were found to be important factors that affect a child\'s nutritional status between 6 and 59 months. 15% of the overall variation is attributable to the Kebeles level, according to two-level multilevel ordinal logistic regressions with estimates of the variation attributable to the Kebeles level equal to 0.569 and an intraclass correlation coefficient of 0.15. Due to the nature of the response variable random intercept model with random coefficients fitted the data adequately in predicting the severity status of children aged 6-59 months\' malnutrition for the multilevel ordinal logistic regression model analysis. So, the researcher recommended that implementing primary health care and nutrition programs that would fit each kebeles\' features in Itang Special Woreda to safeguard children from nutritional deficiency.
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  • 文章类型: Journal Article
    哪些人体测量指标在预测高血压风险方面最好,以及人体测量与血压(BP)的关系如何存在争议。本研究旨在评估血压与人体测量指标之间的关系,并确定高血压风险的最佳预测因子。
    这项横断面研究是对415名连续参与者(161名男性,平均年龄:33.4岁)伊斯坦布尔18-88岁,土耳其。重量,高度,腰围(WC),颈围(NC)和血压由训练有素的人员测量。计算腰围身高比(WHtR)和体重指数(BMI)。皮尔逊相关性,线性回归,多变量分析用于评估人体测量学测量值与SBP之间的关系,DBP,使用社会科学23.0版的统计软件包。
    收缩压(SBP)和舒张压(DBP)与体重有关,WC,NC,BMI,和WHtR(P<0.05)。线性回归分析显示,BMI和WC是SBP的独立危险因素,当BMI增加1个单位时,男性SBP增加1.11mmHg(P=0.036),女性SBP增加1.59mmHg(P=0.001)。而不论性别,当WC增加1个单位时,SBP增加0.2mmHg(P=0.013)。
    我们的结果表明,BMI和WC与BP和高血压风险的重要预测因子有关。因此,在土耳其成年人中,推荐使用BMI和WC作为预测高血压风险的筛查工具.
    UNASSIGNED: It is controversial which anthropometric indexes are the best in predicting the risk of hypertension and how anthropometric measurements are related to blood pressure (BP). This study aimed to evaluate the relationship between BP and anthropometric indexes and to determine the best predictors for hypertension risk.
    UNASSIGNED: This cross-sectional study was conducted with 415 consecutive participants (161 men, mean age: 33.4 years) aged 18-88 years in Istanbul, Turkey. Weight, height, waist circumference (WC), and neck circumference (NC) and BP were measured by well-trained personnel. Waist-to-height ratio (WHtR) and body mass index (BMI) were calculated. Pearson correlation, linear regression, and multivariate analyses were used to assess the relationship between anthropometric measurements and SBP, DBP, using the Statistical Package for the Social Sciences version 23.0.
    UNASSIGNED: The systolic BP (SBP) and diastolic BP (DBP) were related to weight, WC, NC, BMI, and WHtR (P < 0.05). Linear regression analyses showed BMI and WC as independent risk factors for SBP with an increase by 1.11 mmHg in men (P = 0.036) and 1.59 mmHg in women (P = 0.001) in SBP when BMI increased 1 unit, while SBP increases by 0.2 mmHg when WC increases by 1 unit regardless of gender (P = 0.013).
    UNASSIGNED: Our results showed that BMI and WC are related to BP and important predictors of hypertension risk. Therefore, the uses of BMI and WC are recommended as screening tools for the prediction of hypertension risk among Turkish adults.
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  • 文章类型: Journal Article
    目的:功能障碍综合征(DS)的特征是功能性残疾的临床危险因素的积累,比如骨质疏松症,少肌症,和肥胖。影响运动和感觉系统的神经系统疾病也可能导致这种情况,导致步态和肌肉力量紊乱,以及跌倒和骨折的历史。该研究旨在确定不同身体部位的脂肪分布与老年人患DS的几率之间的关系。因为脂肪的积累与病情最密切相关的区域仍然存在不确定性。
    方法:这项横断面研究是根据布什尔老年人健康队列(BEH)第二阶段的数据进行的。根据其标准的至少三个结果的同时发生来定义运动失调综合征。使用双能X射线吸收法(DXA)和人体测量学研究来测量身体成分。为了评估关系,采用多因素logistic回归和调整单因素线性回归。
    结果:在研究中招募的2,359人,1,277名参与者(54.13%)患有DS。根据最终的肢体区域逻辑回归模型,FM和FM与FFM的比率与DS显著相关[OR(95CI)=1.04(1.02至1.05),和3.42(1.95至5.99),分别]。此外,在树干区域,FM和FM与FFM之比与DS的几率显着相关,尽管这种关系比四肢区域弱[OR(95CI)=1.02(1.00至1.03),和2.45(1.36至4.39),分别]。
    结论:我们的研究结果表明,较高的区域和全身脂肪量而不是无脂肪量与DS的风险增加密切相关,尤其是老年人。值得注意的是,四肢(尤其是腿部)的脂肪量增加与DS的几率增加有关,而较高的android与gynoid脂肪质量比与较低的DS风险相关。筛查老年人的脂肪量分布可能是及时诊断DS的有价值的策略,实施干预措施以预防残疾,提高他们的生活质量。
    OBJECTIVE: Dysmobility Syndrome (DS) is characterized as an accumulation of clinical risk factors for functional disability, such as osteoporosis, sarcopenia, and obesity. Neurological disorders that affect the motor and sensory systems can also contribute to the condition, resulting in gait and muscle strength disturbances, as well as a history of falls and fractures. The study aimed to determine the association between fat distribution in different body areas and the odds of older adults developing DS, as there is still uncertainty about the accumulation of fat in which area is most closely linked to the condition.
    METHODS: This cross-sectional study was conducted according to the data from the second phase of the Bushehr Elderly Health Cohort (BEH). Dysmobility Syndrome was defined based on the co-occurrence of at least three outcomes of its criteria. Body composition was measured using dual-energy X-ray absorptiometry (DXA) and anthropometric studies. For evaluating the relationship, multivariate logistic regression and adjusted univariate linear regression were used.
    RESULTS: Of 2,359 who were recruited in the study, 1,277 participants (54.13%) had DS. According to the final logistic regression model in the limb region, FM and FM to FFM ratios were significantly associated with DS [OR (95%CI) = 1.04 (1.02 to 1.05), and 3.42 (1.95 to 5.99), respectively]. Also, In the trunk region, the FM and FM to FFM ratio were significantly related to the odds of DS, although this relationship was weaker than in the limbs region [OR (95%CI) = 1.02 (1.00 to 1.03), and 2.45 (1.36 to 4.39), respectively].
    CONCLUSIONS: Our findings indicate that a higher regional and whole-body amount of fat mass rather than fat-free mass is closely linked to an increased risk of DS, particularly in the elderly population. Notably, higher fat mass in the limbs (especially in the legs) is associated with greater odds of DS, while a higher android-to-gynoid fat mass ratio is associated with lower DS risk. Screening fat mass distribution in older individuals can be a valuable strategy for promptly diagnosing DS, implementing interventions to prevent disabilities, and improving their quality of life.
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  • 文章类型: Clinical Study
    背景:在本研究中,我们分析了综合酸奶康复训练对乳腺癌根治术患者术后辅助治疗副作用及术后身心健康的影响。这项调查的目的是检验以下假设:12周的瑜伽士训练会减少上臂的外周直径,提高灵活性和姿势,与未治疗的对照组相比,改善睡眠质量。
    方法:选择上海地区行乳腺癌根治术的女性患者36例,随机分为实验组(n=20)和对照组(n=16)。实验组患者行瑜伽士综合康复训练,而对照组不参加酸奶课程。在培训前后,对实验组和对照组进行了人体测量和“匹兹堡睡眠质量指数(PSQI)”问卷。
    结果:实验组通过瑜伽士训练纠正驼背姿势。脊柱伸展增加了他们的身高并降低了他们的BMI。上臂关节伸展运动范围,弯曲和外展增加。上臂的外周直径减小,握力增加,睡眠质量逐渐改善。
    结论:(1)延长瑜伽士训练时间稳定并改善患者的身心健康。(2)在瑜伽课程中,为患者提供正确的膈呼吸指导,并结合瑜伽放松技巧可以有效提高患者的睡眠质量。(3)运动方案的设计必须考虑到个体差异。
    BACKGROUND: In the present study, we analyzed the effects of comprehensive yogalates rehabilitation training on side effects caused by postoperative adjuvant treatment and postoperative physical and mental health in breast cancer patients who had undergone radical mastectomy.The purpose of this investigation was to test the hypothesis that 12 weeks of yogalates training would reduce the peripheral diameter of the upper arm, improve flexibility and posture, and improve sleep quality compared with a non-treated control group.
    METHODS: 36 women with breast cancer who had undergone radical mastectomy in Shanghai were selected and randomly divided into the experimental group (n=20) and the control group (n=16). The patients in the experimental group underwent yogalates comprehensive rehabilitation training, while the control group did not participate in yogalates course. Anthropometric measurements and the \"Pittsburgh Sleep Quality Index (PSQI)\" questionnaire were administered to both the experimental and control groups before and after the training sessions.
    RESULTS: The experimental group corrected the hunchback posture through yogalates training. Spine extension increased their height and decreased their BMI. The range of motion of upper arm joints in extension, bending and abduction increased. The peripheral diameter of the upper arm decreased, the grip strength increased, and the sleep quality gradually improved.
    CONCLUSIONS: (1)Prolonging the period of yogalates training stabilized and improve the physical and mental health of patients. (2)In yogalates course, providing proper guidance to patients for diaphragmatic breathing and incorporating yoga relaxation techniques can effectively enhance the sleep quality of patients.(3)Exercise regimens must be designed taking into account individual differences.
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  • 文章类型: Journal Article
    随着肌少症肥胖(SO)的代谢意义被揭示,找到合适的索引来检测SO很重要,特别是2型糖尿病(T2DM)患者伴随代谢功能障碍。
    来自韩国Guro糖尿病计划的参与者(n=515)被包括在内,以比较腰围(WC)的好坏,腰臀比(WHR),腰部高度比(WHtR),体重调整腰围指数(WWI)预测初诊T2DM患者的SO。根据2019年亚洲肌肉减少症工作组的指南,将肌肉减少症定义为低肌肉质量(男性阑尾骨骼肌[ASM]/高度2<7.0kg/m2,女性<5.4kg/m2)和力量(男性握力<28.0kg,女性<18.0公斤)和/或身体表现降低(步态速度<1.0m/sec)。肥胖定义为男性WC≥90厘米,女性WC≥85厘米。WHR,WHtR,第一次世界大战是通过将WC除以臀围来计算的,高度,和√重量,分别。
    WC,WHR,WHtR与以躯干脂肪量(TFA)和ASM表示的脂肪和肌肉质量呈正相关,而第一次世界大战与TFA成正比,与ASM成反比。在四项测试中,WWI显示了SO的接收器操作特性曲线下的最高区域。WWI还显示与蛋白尿和平均臂踝脉搏波速度呈正相关,尤其是年龄≥65岁的患者。
    WWI是预测T2DM患者SO的首选人体测量指标,它可能是预测老年人心脏代谢危险因素的适当指标。
    UNASSIGNED: As the metabolic significance of sarcopenic obesity (SO) is revealed, finding an appropriate index to detect SO is important, especially for type 2 diabetes mellitus (T2DM) patients with accompanying metabolic dysfunction.
    UNASSIGNED: Participants (n=515) from the Korea Guro Diabetes Program were included to compare how well waist circumference (WC), waist hip ratio (WHR), waist height ratio (WHtR), and the weight-adjusted waist index (WWI) predict SO in newly diagnosed T2DM patients. Sarcopenia was defined based on guidelines from the 2019 Asian Working Group for Sarcopenia as both low muscle mass (appendicular skeletal muscle [ASM]/height2 <7.0 kg/m2 for men, <5.4 kg/m2 for women) and strength (handgrip strength <28.0 kg for men, <18.0 kg for women) and/or reduced physical performance (gait speed <1.0 m/sec). Obesity was defined as a WC ≥90 cm in men and ≥85 cm in women. The WHR, WHtR, and WWI were calculated by dividing the WC by the hip circumference, height, and √ weight, respectively.
    UNASSIGNED: The WC, WHR, and WHtR correlated positively with the fat and muscle mass represented by truncal fat amount (TFA) and ASM, whereas the WWI was proportional to the TFA and inversely related to ASM. Of the four indices, the WWI showed the highest area under the receiver operative characteristic curve for SO. The WWI also exhibited a positive correlation with albuminuria and the mean brachial-ankle pulse wave velocity, especially in patients aged ≥65 years.
    UNASSIGNED: The WWI is the preferable anthropometric index for predicting SO in T2DM patients, and it might be a proper index for predicting cardiometabolic risk factors in elderly people.
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  • 文章类型: Journal Article
    哮喘作为一种慢性疾病可能会影响其生长过程。这项研究的目的是调查2-18岁哮喘儿童的人体测量指标,并将其与对照组进行比较。
    在一项病例对照研究中,随机纳入150例2~18岁的哮喘患儿为病例组,300例年龄、性别相匹配的健康儿童为对照组。高度,体重,用标准方法测量两组的体重指数(BMI),并计算Z评分。使用SPSS对数据进行分析,卡方和方差分析。
    完全,对290名男孩(64.4%)和160名女孩(35.6%)进行了评估,平均年龄为6.58±2.82岁。病例组身高明显低于健康对照组(117.00±0.17cmvs.121.00±0.15cm,P=0.025)。体重无显著差异(23.13±9.75kg与24.62±10.36kg,P=0.145)和BMI(16.32±3.10kg/m2vs.病例组和对照组16.28±3.16kg/m2,P=0.900),分别。身高Z值正常与异常无明显关系,病例组和对照组的体重和BMI(P>0.05)。
    尽管两组的年龄相差4厘米,身高没有差异,体重和BMI在两组之间可能是由于病例组中疾病控制良好或缺乏显著的哮喘生长相关效应。
    UNASSIGNED: Asthma as a chronic disease may affect the growth process. The aim of this study was to investigate the anthropometric indices in 2-18 years old children with asthma and compare them with the control group.
    UNASSIGNED: In a case-control study, 150 asthmatic children with age of 2-18 years as case group and 300 age- and sex-matched healthy children as control group were randomly included. The height, weight, and body mass index (BMI) of both group measured by the standard method and Z score was calculated. Data were analyzed using SPSS, chi-square and analysis of variance.
    UNASSIGNED: Totally, 290 boys (64.4%) and 160 girls (35.6%) with mean age of 6.58±2.82 years were evaluated. Case group had significantly lower height compared to the healthy control group (117.00±0.17 cm vs. 121.00±0.15 cm respectively, P=0.025). No significant differences were detected in weight (23.13±9.75 kg vs. 24.62±10.36 kg, P=0.145) and BMI (16.32±3.10 kg/m2 vs. 16.28±3.16 kg/m2, P=0.900) between case and control groups, respectively. There were no significant relationships between normal and abnormal Z scores of height, weight and BMI in case and control group (P>0.05).
    UNASSIGNED: Despite 4 cm difference between the age of two groups, no differences in height, weight ad BMI between two groups may be due to good control of the disease in the case group or lack of significant growth related effect of asthma.
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  • 文章类型: Journal Article
    背景:结直肠癌(CRC),肥胖之间有联系,尤其是内脏脂肪.身体圆度指数(BRI)可以更准确地评估体内脂肪和内脏脂肪水平。是的,然而,未知BRI是否与CRC风险相关。
    方法:53,766名参与者来自国家健康和营养调查(NHANES)。使用逻辑回归分析BRI与CRC风险之间的相关性。分层分析揭示了基于种群类型的关联。使用不同的人体测量指标进行受试者工作特征曲线(ROC)预测CRC风险。
    结果:与正常参与者相比,CRC参与者的风险明显升高,BRI升高(P趋势<0.001)。即使在调整了所有协变量后,这种关联仍然存在(P趋势=0.017)。在分层分析中,CRC风险随着BRI的增加而增加,特别是那些不活跃的人(OR(95%CI):第三季度3.761(2.139,6.610),P<0.05,Q45.972(3.347,8.470),P<0.01),超重(OR(95%CI):第三季度2.573(1.012,7.431),P<0.05,Q43.318(1.221,9.020),P<0.05)或肥胖(OR(95%CI):Q33.889(1.829,8.266),P<0.001,第四季度4.920(2.349,10.308),P<0.001)。ROC曲线显示,BRI比体重等其他人体测量指标具有更好的预测CRC风险的能力。(均P<0.05)。
    结论:CRC风险与BRI呈正相关,特别是在BMI≥25kg/m2的非活动参与者中。希望这些结果将提高人们对减少内脏脂肪沉积重要性的认识。
    BACKGROUND: Colorectal cancer (CRC), has a link between obesity, especially visceral fat. The body roundness index (BRI) can more accurately assess body fat and visceral fat levels. It is, however, unknown whether BRI is associated with CRC risk.
    METHODS: 53,766 participants were enrolled from the National Health and Nutrition Examination Survey (NHANES). Analysing the corelation between BRI and CRC risk was performed using logistic regression. Stratified analyses revealed the association based on the population type. Receiver operating characteristic curve (ROC) was performed for predicting CRC risk using different anthropometric indices.
    RESULTS: The risk of CRC mounting apparently with elevated BRI for participants with CRC compared to normal participants (P-trend < 0.001). The association persisted even after adjusting for all covariates (P-trend = 0.017). In stratified analyses, CRC risk increased with increasing BRI, especially among those who were inactive (OR (95% CI): Q3 3.761 (2.139, 6.610), P < 0.05, Q4 5.972 (3.347, 8.470), P < 0.01), overweight (OR (95% CI): Q3 2.573 (1.012, 7.431), P < 0.05, Q4 3.318 (1.221, 9.020), P < 0.05) or obese (OR (95% CI): Q3 3.889 (1.829, 8.266), P < 0.001, Q4 4.920 (2.349, 10.308), P < 0.001). ROC curve showed that BRI had a better ability in forecasting the risk of CRC than other anthropometric indices such as body weight etc. (all P < 0.05).
    CONCLUSIONS: CRC risk and BRI have a positive and significant relationship, particularly in inactive participants with BMI ≥ 25 kg/m2. It is hoped that these results will raise awareness of the importance of reducing visceral fat deposition.
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  • 文章类型: Journal Article
    背景:姜黄素补充剂可通过其抗氧化和抗炎特性促进体重减轻和改善肥胖相关并发症。
    目的:对随机对照试验(RCT)进行了综述和最新的荟萃分析,以评估补充姜黄素对人体测量指标的影响。
    方法:从电子数据库中确定RCT的系统评价和荟萃分析(SRMA)(Medline,Scopus,Cochrane和GoogleScholar)至2022年3月31日,无语言限制。如果他们根据任何体重指数(BMI)评估姜黄素补充剂,体重(BW),或腰围(WC)。进行亚组分析,按患者类型分层,肥胖的严重程度和姜黄素配方。研究方案是先验注册的(PROSPERO;CRD420223221112)。包括14个SRMA和39个单独的RCT,具有高度重叠。此外,搜索是从4月份对包含的SRMA的最后一次搜索中更新的,2021年至2022年3月31日,我们发现了11个额外的RCT,使更新的MA中包含的RCT总数达到50个。其中,21项RCT被归类为高偏倚风险。补充姜黄素显著降低BMI,BW,和WC,平均差异(MD)为-0.24kg/m2(95%CI:-0.32,-0.16),-0.59千克(95%CI:-0.81,-0.36)和-1.32厘米(95%CI:-1.95,-0.69),分别。生物利用度增强形式降低BMI,BW和WC更多,MD为-0.26kg/m2(95%CI:-0.38,-0.13),-0.80千克(95%CI:-1.38,-0.23)和-1.41厘米(95%CI:-2.24,-0.58),分别。在患者亚组中也看到了显着的效果,尤其是肥胖和糖尿病的成年人。
    结论:姜黄素的补充能显著降低人体测量指数,生物利用度增强的配方是优选的。通过改变生活方式来增加姜黄素补充剂应该是减轻体重的一种选择。
    Curcumin supplementation may promote weight loss and ameliorate obesity-related complications through its antioxidative and anti-inflammatory properties.
    An umbrella review and updated meta-analysis of randomized controlled trials (RCTs) was conducted to evaluate the effect of curcumin supplementation on anthropometric indices.
    Systematic reviews and meta-analyses (SRMAs) of RCTs were identified from electronic databases (Medline, Scopus, Cochrane, and Google Scholar) up to 31 March, 2022, without language restriction. SRMAs were included if they assessed curcumin supplementation on any of the following: BMI, body weight (BW), or waist circumference (WC). Subgroup analyses were performed, stratifying by patient types, severity of obesity, and curcumin formula. The study protocol was a priori registered.
    From an umbrella review, 14 SRMAs with 39 individual RCTs were included with a high degree of overlap. In addition, searching was updated from the last search of included SRMAs in April 2021 up to 31 March, 2022, and we found 11 additional RCTs, bringing the total up to 50 RCTs included in the updated meta-analyses. Of these, 21 RCTs were deemed of high risk of bias. Curcumin supplementation significantly reduced BMI, BW, and WC with mean differences (MDs) of -0.24 kg/m2 (95% CI: -0.32, -0.16 kg/m2), -0.59 kg (95% CI: -0.81, -0.36 kg), and -1.32 cm (95% CI: -1.95, -0.69 cm), respectively. The bioavailability-enhanced form reduced BMI, BWs, and WC more, with MDs of -0.26 kg/m2 (95% CI: -0.38, -0.13 kg/m2), -0.80 kg (95% CI: -1.38, -0.23 kg) and -1.41 cm (95% CI: -2.24, -0.58 cm), respectively. Significant effects were also seen in subgroups of patients, especially in adults with obesity and diabetes.
    Curcumin supplementation significantly reduces anthropometric indices, and bioavailability-enhanced formulas are preferred. Augmenting curcumin supplement with lifestyle modification should be an option for weight reduction. This trial was registered at PROSPERO as CRD42022321112 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022321112).
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  • 文章类型: Meta-Analysis
    目的:一些试验已经评估了补充叶酸对肥胖指数的影响。然而,他们的结果不一致。因此,本研究的荟萃分析旨在总结现有随机临床试验(RCT)中有关补充叶酸对体重和体重指数(BMI)影响的数据.
    方法:Medline/PubMed,Scopus,Embase,和ISI科学网进行了搜索,以确定截至2020年12月的相关文章。使用随机效应模型将效应大小表示为加权平均差(WMD)和95%置信区间(CI)。
    结果:来自9项研究的汇总数据表明,补充叶酸不会改变体重(WMD:-0.16kg,95CI:-0.47至0.16,P=0.32)和BMI(WMD:-0.23kg/m2,95CI:-0.49至0.03,P=0.31),但纳入的BMI研究之间存在显著异质性(I2=90.1%,P<0.001)。此外,对同型半胱氨酸水平和健康状况的亚组分析表明,在同型半胱氨酸水平≥15μmol/L的患者(WMD:-0.17kg/cm2,-0.33至-0.01,p=0.03)中,补充叶酸对BMI有显着影响。多囊卵巢综合征(PCOS)(WMD:-0.30kg/cm2,-0.54至-0.06,p=0.01)。
    结论:我们的结果表明,叶酸可以改善同型半胱氨酸水平≥15μmol/L的患者和PCOS女性的BMI。
    Several trials have evaluated the effects of folate supplementation on obesity indices. However, their results were inconsistent. Therefore, the current meta-analysis was conducted to summarize data from available randomized clinical trials (RCTs) about the impact of folate supplementation on weight and body mass index (BMI).
    Medline/PubMed, Scopus, Embase, and ISI web of science were searched to identify relevant articles up to December 2020. The effect sizes were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI) using the random-effects model.
    Pooled data from nine studies showed that folic acid supplementation did not change body weight (WMD: -0.16 kg, 95%CI: -0.47 to 0.16, P = 0.32) and BMI (WMD: -0.23 kg/m2, 95%CI: -0.49 to 0.03, P = 0.31), but there was significant heterogeneity between the included studies for BMI (I2 = 90.1%, P < 0.001). Moreover, subgroup analyses in level of homocysteine and health status indicated significant effect of folic acid supplementation on BMI in those with homocysteine level ≥15 μmol/L (WMD: -0.17 kg/cm2, -0.33 to -0.01, p = 0.03) and in women with polycystic ovary syndrome (PCOS) (WMD: - 0.30kg/cm2, -0.54 to -0.06, p = 0.01).
    Our outcomes demonstrated that folic acid improves BMI in those with homocysteine levels ≥15 μmol/L and women with PCOS.
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