Abstract：
Curcumin supplementation may promote weight loss and ameliorate obesity-related complications through its antioxidative and anti-inflammatory properties.
An umbrella review and updated meta-analysis of randomized controlled trials (RCTs) was conducted to evaluate the effect of curcumin supplementation on anthropometric indices.
Systematic reviews and meta-analyses (SRMAs) of RCTs were identified from electronic databases (Medline, Scopus, Cochrane, and Google Scholar) up to 31 March, 2022, without language restriction. SRMAs were included if they assessed curcumin supplementation on any of the following: BMI, body weight (BW), or waist circumference (WC). Subgroup analyses were performed, stratifying by patient types, severity of obesity, and curcumin formula. The study protocol was a priori registered.
From an umbrella review, 14 SRMAs with 39 individual RCTs were included with a high degree of overlap. In addition, searching was updated from the last search of included SRMAs in April 2021 up to 31 March, 2022, and we found 11 additional RCTs, bringing the total up to 50 RCTs included in the updated meta-analyses. Of these, 21 RCTs were deemed of high risk of bias. Curcumin supplementation significantly reduced BMI, BW, and WC with mean differences (MDs) of -0.24 kg/m2 (95% CI: -0.32, -0.16 kg/m2), -0.59 kg (95% CI: -0.81, -0.36 kg), and -1.32 cm (95% CI: -1.95, -0.69 cm), respectively. The bioavailability-enhanced form reduced BMI, BWs, and WC more, with MDs of -0.26 kg/m2 (95% CI: -0.38, -0.13 kg/m2), -0.80 kg (95% CI: -1.38, -0.23 kg) and -1.41 cm (95% CI: -2.24, -0.58 cm), respectively. Significant effects were also seen in subgroups of patients, especially in adults with obesity and diabetes.
Curcumin supplementation significantly reduces anthropometric indices, and bioavailability-enhanced formulas are preferred. Augmenting curcumin supplement with lifestyle modification should be an option for weight reduction. This trial was registered at PROSPERO as CRD42022321112 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022321112).
An umbrella review and updated meta-analysis of randomized controlled trials (RCTs) was conducted to evaluate the effect of curcumin supplementation on anthropometric indices.
Systematic reviews and meta-analyses (SRMAs) of RCTs were identified from electronic databases (Medline, Scopus, Cochrane, and Google Scholar) up to 31 March, 2022, without language restriction. SRMAs were included if they assessed curcumin supplementation on any of the following: BMI, body weight (BW), or waist circumference (WC). Subgroup analyses were performed, stratifying by patient types, severity of obesity, and curcumin formula. The study protocol was a priori registered.
From an umbrella review, 14 SRMAs with 39 individual RCTs were included with a high degree of overlap. In addition, searching was updated from the last search of included SRMAs in April 2021 up to 31 March, 2022, and we found 11 additional RCTs, bringing the total up to 50 RCTs included in the updated meta-analyses. Of these, 21 RCTs were deemed of high risk of bias. Curcumin supplementation significantly reduced BMI, BW, and WC with mean differences (MDs) of -0.24 kg/m2 (95% CI: -0.32, -0.16 kg/m2), -0.59 kg (95% CI: -0.81, -0.36 kg), and -1.32 cm (95% CI: -1.95, -0.69 cm), respectively. The bioavailability-enhanced form reduced BMI, BWs, and WC more, with MDs of -0.26 kg/m2 (95% CI: -0.38, -0.13 kg/m2), -0.80 kg (95% CI: -1.38, -0.23 kg) and -1.41 cm (95% CI: -2.24, -0.58 cm), respectively. Significant effects were also seen in subgroups of patients, especially in adults with obesity and diabetes.
Curcumin supplementation significantly reduces anthropometric indices, and bioavailability-enhanced formulas are preferred. Augmenting curcumin supplement with lifestyle modification should be an option for weight reduction. This trial was registered at PROSPERO as CRD42022321112 (https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022321112).
摘要：
背景：姜黄素补充剂可通过其抗氧化和抗炎特性促进体重减轻和改善肥胖相关并发症。
目的：对随机对照试验（RCT）进行了综述和最新的荟萃分析，以评估补充姜黄素对人体测量指标的影响。
方法：从电子数据库中确定RCT的系统评价和荟萃分析（SRMA）（Medline，Scopus,Cochrane和GoogleScholar）至2022年3月31日，无语言限制。如果他们根据任何体重指数（BMI）评估姜黄素补充剂，体重(BW),或腰围（WC）。进行亚组分析，按患者类型分层，肥胖的严重程度和姜黄素配方。研究方案是先验注册的(PROSPERO;CRD420223221112)。包括14个SRMA和39个单独的RCT，具有高度重叠。此外,搜索是从4月份对包含的SRMA的最后一次搜索中更新的，2021年至2022年3月31日，我们发现了11个额外的RCT，使更新的MA中包含的RCT总数达到50个。其中,21项RCT被归类为高偏倚风险。补充姜黄素显著降低BMI，BW,和WC，平均差异（MD）为-0.24kg/m2（95％CI：-0.32，-0.16），-0.59千克（95％CI：-0.81，-0.36）和-1.32厘米（95％CI：-1.95，-0.69），分别。生物利用度增强形式降低BMI，BW和WC更多，MD为-0.26kg/m2（95％CI：-0.38，-0.13），-0.80千克（95％CI：-1.38，-0.23）和-1.41厘米（95％CI：-2.24，-0.58），分别。在患者亚组中也看到了显着的效果，尤其是肥胖和糖尿病的成年人。
结论：姜黄素的补充能显著降低人体测量指数，生物利用度增强的配方是优选的。通过改变生活方式来增加姜黄素补充剂应该是减轻体重的一种选择。
目的：对随机对照试验（RCT）进行了综述和最新的荟萃分析，以评估补充姜黄素对人体测量指标的影响。
方法：从电子数据库中确定RCT的系统评价和荟萃分析（SRMA）（Medline，Scopus,Cochrane和GoogleScholar）至2022年3月31日，无语言限制。如果他们根据任何体重指数（BMI）评估姜黄素补充剂，体重(BW),或腰围（WC）。进行亚组分析，按患者类型分层，肥胖的严重程度和姜黄素配方。研究方案是先验注册的(PROSPERO;CRD420223221112)。包括14个SRMA和39个单独的RCT，具有高度重叠。此外,搜索是从4月份对包含的SRMA的最后一次搜索中更新的，2021年至2022年3月31日，我们发现了11个额外的RCT，使更新的MA中包含的RCT总数达到50个。其中,21项RCT被归类为高偏倚风险。补充姜黄素显著降低BMI，BW,和WC，平均差异（MD）为-0.24kg/m2（95％CI：-0.32，-0.16），-0.59千克（95％CI：-0.81，-0.36）和-1.32厘米（95％CI：-1.95，-0.69），分别。生物利用度增强形式降低BMI，BW和WC更多，MD为-0.26kg/m2（95％CI：-0.38，-0.13），-0.80千克（95％CI：-1.38，-0.23）和-1.41厘米（95％CI：-2.24，-0.58），分别。在患者亚组中也看到了显着的效果，尤其是肥胖和糖尿病的成年人。
结论：姜黄素的补充能显著降低人体测量指数，生物利用度增强的配方是优选的。通过改变生活方式来增加姜黄素补充剂应该是减轻体重的一种选择。
