精神分裂症患者患心血管疾病的风险不成比例地增加。高甘油三酯血症在这个人群中很普遍,然而这与残余胆固醇的水平有什么关系,富含甘油三酯(TG)的脂蛋白(TRL)粒径和组成,TG营业额,载脂蛋白(apo)和血管生成素样蛋白(ANGPTL)浓度未知。空腹胆固醇水平(总[TC],LDL-C,HDL-C,在110例诊断为精神分裂症的患者中测定了non-HDL-C和残余胆固醇)和TG,和46个健康对照。TRL粒径,浓度和成分,和β-羟基丁酸酯(TG转换标记)通过NMR评估。ApoCII,apoCIII,apoE,用ELISA法检测ANGPTL3、ANGPTL4和ANGPTL8水平,和apoCII,在HDL和非HDL组分中进一步评估了apoCIII和apoE。精神分裂症患者TG显著升高,TG:apoB比值,非HDL-C,残余胆固醇,非HDL-apoCII和非HDL-apoCIII,和HDL-apoE(所有p<0.05),较低的HDL-C和apoA-I(所有p<0.001),和类似的apoB,TC,TC:apoB比率,LDL-C,β-羟基丁酸酯,ANGPTL3、ANGPTL4和ANGPTL8用于健康对照。患者的大和中TRL颗粒浓度分别增加了12.0和2.5倍,但每个颗粒内的胆固醇:TG比例相似。血浆TG,残余胆固醇,大,中TRL颗粒浓度与apoCII密切相关,apoCIII,和apoE在非HDL部分,精神分裂症患者HDL分数中的apoCIII和apoE。TG的差异,HDL-C,TRL颗粒浓度,调整常规危险因素后,患者和对照组之间的apoCIII和apoE持续存在。精神分裂症患者与残余胆固醇升高相关的大和中TRL种类明显增加,apoCII,apoCIII和apoE.这些结果与可能对靶向apoCIII有反应的受损TRL脂解和清除一致。
Patients with schizophrenia show a disproportionally increased risk of cardiovascular disease. Hypertriglyceridemia is prevalent in this population, however how this relates to levels of remnant cholesterol, triglyceride (TG)-rich lipoprotein (TRL) particle size and composition, TG turnover, and apolipoprotein (apo) and angiopoietin-like protein (ANGPTL) concentrations is unknown. Fasting levels of cholesterol (total [TC], LDL-C, HDL-C, non-HDL-C and remnant cholesterol) and TG were determined in 110 patients diagnosed with schizophrenia, and 46 healthy controls. TRL particle size, concentration and composition, and β-hydroxybutyrate (TG turnover marker) were assessed by NMR. ApoCII, apoCIII, apoE, ANGPTL3, ANGPTL4 and ANGPTL8 levels were measured by ELISA, and apoCII, apoCIII and apoE were further evaluated in HDL and non-HDL fractions. Patients with schizophrenia had significantly elevated TG, TG:apoB ratio, non-HDL-C, remnant cholesterol, non-HDL-apoCII and non-HDL-apoCIII, and HDL-apoE (all p<0.05), lower HDL-C and apoA-I (all p<0.001), and comparable apoB, TC, TC:apoB ratio, LDL-C, β-hydroxybutyrate, ANGPTL3, ANGPTL4 and ANGPTL8 to healthy controls. Patients had a 12.0- and 2.5-fold increase in the concentration of large and medium TRL particles respectively, but similar cholesterol:TG ratio within each particle. Plasma TG, remnant cholesterol, and large and medium TRL particle concentrations correlated strongly with apoCII, apoCIII, and apoE in the non-HDL fraction, and with apoCIII and apoE in the HDL fraction in patients with schizophrenia. Differences in TG, HDL-C, TRL particle concentrations, apoCIII and apoE between patients and controls persisted after adjustment for conventional risk factors. Patients with schizophrenia have a marked increase in large and medium TRL species associated with elevated remnant cholesterol, apoCII, apoCIII and apoE. These results are consistent with impaired TRL lipolysis and clearance which may be responsive to targeting apoCIII.