■低聚Aβ(OAβ)是阿尔茨海默病(AD)诊断的有希望的候选标志物。脑电图(EEG)是早期发现AD的潜在工具。尽管如此,脑电图功率比,特别是θ/α比(TAR)和θ/β比(TBR),反映Aβ负担-认知功能障碍和AD的主要机制。这项研究基于MDS-OAβ水平调查了TAR和TBR与老年人淀粉样蛋白负荷的关系。
■529人(年龄≥60岁)被招募。所有参与者都接受了脑电图(MINDD扫描,YbrainInc.,韩国)和AlzOn™测试(PeopleBioInc.,京夷道,大韩民国)用于定量血浆中的MDS-OAβ值。对EEG变量进行对数变换以归一化数据分布。使用MDS-OAβ截断值(0.78ng/mL),将所有参与者分为两组:高MDS-OAβ和低MDS-OAβ.
■MDS-OAβ水平高的参与者的TAR和TBR明显高于MDS-OAβ水平低的参与者。中心叶中对数变换的TBR(β=0.161,p=0.0026),额叶(β=0.145,p=0.0044),顶叶(β=0.166,p=0.0028),枕叶(β=0.158,p=0.0058),和颞叶(β=0.162,p=0.0042)与MDS-OAβ水平的升高显着正相关。在调整Bonferroni校正后,所有叶区域的TBR,除了枕叶,与MDS-OAβ水平升高显著相关。
■我们发现老年人中MDS-OAβ与TBR显著相关。这一发现表明,淀粉样蛋白负荷的增加可能与低频带的增加和相对高频带的减少有关。
UNASSIGNED: Oligomeric Aβ (OAβ) is a promising candidate marker for Alzheimer\'s disease (AD) diagnosis. Electroencephalography (EEG) is a potential tool for early detection of AD. Still, whether EEG power ratios, particularly the theta/alpha ratio (TAR) and theta/beta ratio (TBR), reflect Aβ burden-a primary mechanism underlying cognitive impairment and AD. This study investigated the association of TAR and TBR with amyloid burden in older adults based on MDS-OAβ levels.
UNASSIGNED: 529 individuals (aged ≥60 years) were recruited. All participants underwent EEG (MINDD SCAN, Ybrain Inc., South Korea) and AlzOn™ test (PeopleBio Inc., Gyeonggi-do, Republic of Korea) for quantifying MDS-OAβ values in the plasma. EEG variables were log-transformed to normalize the data distribution. Using the MDS-OAβ cutoff value (0.78 ng/mL), all participants were classified into two groups: high MDS-OAβ and low MDS-OAβ.
UNASSIGNED: Participants with high MDS-OAβ levels had significantly higher TARs and TBRs than those with low MDS-OAβ levels. The log-transformed TBRs in the central lobe (β = 0.161, p = 0.0026), frontal lobe (β = 0.145, p = 0.0044), parietal lobe (β = 0.166, p = 0.0028), occipital lobe (β = 0.158, p = 0.0058), and temporal lobe (beta = 0.162, p = 0.0042) were significantly and positively associated with increases in MDS-OAβ levels. After adjusting for the Bonferroni correction, the TBRs in all lobe regions, except the occipital lobe, were significantly associated with increased MDS-OAβ levels.
UNASSIGNED: We found a significant association of MDS-OAβ with TBR in older adults. This finding indicates that an increase in amyloid burden may be associated with an increase in the low-frequency band and a decrease in the relatively high-frequency band.