Abstract：
Amyloidosis is a condition involving a disparate group of pathologies characterized by the extracellular deposition of insoluble fibrils composed of broken-down proteins. These proteins can accumulate locally, causing peculiar symptoms, or in a widespread way, involving many organs and. causing severe systemic failure. The damage that is created is related not only to the accumulation of. amyloid fibrils but above all to the precursor oligomers of the fibrils that manage to enter the cell in a very particular way. This article analyzes the current state of research related to the entry of these oligomers into the cell membrane and the theories related to their toxicity. The paper proposed here not only aims to review the contents in the literature but also proposes a new vision of amyloid toxicity. that could occur in a multiphase process catalyzed by the cell membrane itself. In this process, the denaturation of the lipid bilayer is followed by the stabilization of a pore through energetically favorable self-assembly processes which are achieved through particular oligomeric structures.
摘要：
淀粉样变性是涉及一组不同病理的病症,其特征在于由分解蛋白组成的不溶性原纤维的细胞外沉积。这些蛋白质可以在局部积累，引起特殊症状，或者以广泛的方式，涉及许多器官和。导致严重的系统故障。造成的损害不仅与积累有关。淀粉样原纤维，但最重要的是原纤维的前体寡聚物以非常特殊的方式进入细胞。本文分析了与这些寡聚体进入细胞膜相关的研究现状以及与其毒性相关的理论。本文不仅旨在回顾文献中的内容，而且还提出了淀粉样蛋白毒性的新视野。这可能发生在由细胞膜本身催化的多相过程中。在这个过程中,脂质双层的变性之后是通过能量上有利的自组装过程来稳定孔,所述自组装过程通过特定的寡聚结构来实现。
